Search KCNH2 Variants (search from cDNA/chromosome coordinates)

The disease most commonly associated with variants in KCNH2 is long QT type 2 (LQT2; OMIM: 613688). Coding variants are referenced to isoform "A" (Q12809-1, transcript ENST00000262186.10) or "B" (Q12809-2, transcript ENST00000330883.9) to match convention. Total Carriers is the number of heterozygotes diagnosed with LQT2 or Unaffected with disease, and found in the genome aggregation database (gnomAD). Click variant link for more details.

Variant Isoform Residue Total Carriers LQT2 Unaffected & gnomAD Function LQT2 Hotspot Estimated LQT2 Penetrance
A1017D A 1017 0 0 0 NA Non_Hotspot 8.9%
A1017G A 1017 0 0 0 NA Non_Hotspot 8.1%
A1017P A 1017 0 0 0 NA Non_Hotspot 7.2%
A1017S A 1017 1 0 1 NA Non_Hotspot 5.3%
A1017T A 1017 2 0 2 NA Non_Hotspot 6%
A1017V A 1017 3 0 3 NA Non_Hotspot 6.1%
A1044D A 1044 0 0 0 NA Non_Hotspot 13.7%
A1044G A 1044 0 0 0 NA Non_Hotspot 13.8%
A1044P A 1044 0 0 0 NA Non_Hotspot 12.4%
A1044S A 1044 0 0 0 NA Non_Hotspot 11.3%
A1044T A 1044 0 0 0 NA Non_Hotspot 11.3%
A1044V A 1044 0 0 0 NA Non_Hotspot 8.3%
A1058E A 1058 1 0 1 NA Non_Hotspot 8.2%
A1058G A 1058 0 0 0 NA Non_Hotspot 8.3%
A1058P A 1058 0 0 0 NA Non_Hotspot 9.2%
A1058S A 1058 0 0 0 NA Non_Hotspot 6%
A1058T A 1058 2 0 2 NA Non_Hotspot 4.1%
A1058V A 1058 0 0 0 NA Non_Hotspot 8.3%
A1061D A 1061 0 0 0 NA Mild_Hotspot 12.8%
A1061G A 1061 0 0 0 NA Mild_Hotspot 8.5%
A1061P A 1061 3 1 2 NA Mild_Hotspot 18.3%
A1061S A 1061 0 0 0 NA Mild_Hotspot 10.5%
A1061T A 1061 0 0 0 NA Mild_Hotspot 12.7%
A1061V A 1061 0 0 0 NA Mild_Hotspot 15.5%
A1077D A 1077 1 0 1 NA Non_Hotspot 9.3%
A1077G A 1077 0 0 0 NA Non_Hotspot 8.5%
A1077P A 1077 0 0 0 NA Non_Hotspot 7.6%
A1077S A 1077 0 0 0 NA Non_Hotspot 7.6%
A1077T A 1077 6 0 6 NA Non_Hotspot 4.7%
A1077V A 1077 0 0 0 NA Non_Hotspot 9.5%
A1080D A 1080 0 0 0 NA Non_Hotspot 10.6%
A1080G A 1080 0 0 0 NA Non_Hotspot 9.6%
A1080P A 1080 0 0 0 NA Non_Hotspot 7%
A1080S A 1080 0 0 0 NA Non_Hotspot 7%
A1080T A 1080 0 0 0 NA Non_Hotspot 5.6%
A1080V A 1080 0 0 0 NA Non_Hotspot 8.7%
A1116E A 1116 0 0 0 NA Mild_Hotspot 10.9%
A1116G A 1116 0 0 0 NA Mild_Hotspot 14.7%
A1116P A 1116 0 0 0 NA Mild_Hotspot 14.8%
A1116S A 1116 0 0 0 NA Mild_Hotspot 10.9%
A1116T A 1116 0 0 0 NA Mild_Hotspot 12%
A1116V A 1116 15 3 12 LOF Mild_Hotspot 18%
A1124D A 1124 0 0 0 NA Non_Hotspot 7.4%
A1124G A 1124 0 0 0 NA Non_Hotspot 8.2%
A1124P A 1124 0 0 0 NA Non_Hotspot 7.4%
A1124S A 1124 0 0 0 NA Non_Hotspot 5.4%
A1124T A 1124 0 0 0 NA Non_Hotspot 7.5%
A1124V A 1124 0 0 0 NA Non_Hotspot 7.4%
A1144D A 1144 0 0 0 NA Non_Hotspot 9.1%
A1144G A 1144 0 0 0 NA Non_Hotspot 7.4%
A1144P A 1144 0 0 0 NA Non_Hotspot 5.3%
A1144S A 1144 0 0 0 NA Non_Hotspot 6.7%
A1144T A 1144 4 0 4 NA Non_Hotspot 4.3%
A1144V A 1144 0 0 0 NA Non_Hotspot 7.4%
A121D A 121 0 0 0 NA Mild_Hotspot 15.9%
A121G A 121 0 0 0 NA Mild_Hotspot 15.9%
A121P A 121 0 0 0 NA Mild_Hotspot 15.6%
A121S A 121 0 0 0 NA Mild_Hotspot 10.7%
A121T A 121 0 0 0 NA Mild_Hotspot 11.8%
A121V A 121 0 0 0 NA Mild_Hotspot 8.7%
A142D A 142 0 0 0 NA Non_Hotspot 7.4%
A142G A 142 0 0 0 NA Non_Hotspot 7.4%
A142P A 142 0 0 0 NA Non_Hotspot 7.4%
A142S A 142 0 0 0 NA Non_Hotspot 6.6%
A142T A 142 2 0 2 NA Non_Hotspot 5%
A142V A 142 0 0 0 NA Non_Hotspot 8.3%
A156D A 156 0 0 0 NA Non_Hotspot 9.9%
A156G A 156 0 0 0 NA Non_Hotspot 8.9%
A156P A 156 0 0 0 NA Non_Hotspot 5.8%
A156S A 156 0 0 0 NA Non_Hotspot 6.5%
A156T A 156 0 0 0 NA Non_Hotspot 8%
A156V A 156 0 0 0 NA Non_Hotspot 7.2%
A160D A 160 0 0 0 NA Mild_Hotspot 18.7%
A160G A 160 0 0 0 NA Mild_Hotspot 12.7%
A160P A 160 0 0 0 NA Mild_Hotspot 11.4%
A160S A 160 0 0 0 NA Mild_Hotspot 14%
A160T A 160 0 0 0 NA Mild_Hotspot 17%
A160V A 160 0 0 0 NA Mild_Hotspot 15.5%
A169E A 169 0 0 0 NA Hotspot 84.5%
A169G A 169 1 1 0 NA Hotspot 81.6%
A169P A 169 0 0 0 NA Hotspot 83%
A169S A 169 0 0 0 NA Hotspot 81.5%
A169T A 169 0 0 0 NA Hotspot 83.1%
A169V A 169 0 0 0 NA Hotspot 77.7%
A172E A 172 0 0 0 NA Hotspot 73.8%
A172G A 172 0 0 0 NA Hotspot 78.2%
A172P A 172 0 0 0 NA Hotspot 73.8%
A172S A 172 0 0 0 NA Hotspot 69.4%
A172T A 172 0 0 0 NA Hotspot 76.2%
A172V A 172 1 1 0 NA Hotspot 78.3%
A175D A 175 9 0 9 NA Mild_Hotspot 6.3%
A175G A 175 0 0 0 NA Mild_Hotspot 9%
A175P A 175 0 0 0 NA Mild_Hotspot 13.5%
A175S A 175 4 0 4 NA Mild_Hotspot 7%
A175T A 175 0 0 0 NA Mild_Hotspot 12.3%
A175V A 175 0 0 0 NA Mild_Hotspot 13.5%
A185E A 185 0 0 0 NA Mild_Hotspot 20.4%
A185G A 185 0 0 0 NA Mild_Hotspot 26.7%
A185P A 185 0 0 0 NA Mild_Hotspot 20.5%
A185S A 185 0 0 0 NA Mild_Hotspot 24.7%
A185T A 185 0 0 0 NA Mild_Hotspot 24.9%
A185V A 185 0 0 0 NA Mild_Hotspot 26.9%
A188E A 188 0 0 0 NA Non_Hotspot 9.6%
A188G A 188 0 0 0 NA Non_Hotspot 9.6%
A188P A 188 1 0 1 NA Non_Hotspot 7.1%
A188S A 188 1 0 1 NA Non_Hotspot 7.8%
A188T A 188 0 0 0 NA Non_Hotspot 8.7%
A188V A 188 0 0 0 NA Non_Hotspot 8.7%
A190D A 190 0 0 0 NA Non_Hotspot 9.9%
A190G A 190 0 0 0 NA Non_Hotspot 10%
A190P A 190 0 0 0 NA Non_Hotspot 8.1%
A190S A 190 0 0 0 NA Non_Hotspot 9%
A190T A 190 36 1 35 NA Non_Hotspot 4.1%
A190V A 190 2 0 2 NA Non_Hotspot 7.4%
A193D A 193 0 0 0 NA Hotspot 41.9%
A193G A 193 0 0 0 NA Hotspot 36.6%
A193P A 193 0 0 0 NA Hotspot 36.5%
A193S A 193 0 0 0 NA Hotspot 39.3%
A193T A 193 1 1 0 NA Hotspot 44.6%
A193V A 193 3 1 2 NA Hotspot 37.8%
A203E A 203 0 0 0 NA Non_Hotspot 8.7%
A203G A 203 0 0 0 NA Non_Hotspot 8.7%
A203P A 203 0 0 0 NA Non_Hotspot 7.8%
A203S A 203 0 0 0 NA Non_Hotspot 5.7%
A203T A 203 1 0 1 Normal Non_Hotspot 9.5%
A203V A 203 0 0 0 NA Non_Hotspot 9.7%
A204E A 204 0 0 0 NA Non_Hotspot 7.2%
A204G A 204 0 0 0 NA Non_Hotspot 9%
A204P A 204 0 0 0 NA Non_Hotspot 8.1%
A204S A 204 0 0 0 NA Non_Hotspot 8.1%
A204T A 204 0 0 0 NA Non_Hotspot 9%
A204V A 204 0 0 0 NA Non_Hotspot 9%
A211D A 211 0 0 0 NA Non_Hotspot 9.7%
A211G A 211 0 0 0 NA Non_Hotspot 6.5%
A211P A 211 0 0 0 NA Non_Hotspot 6.4%
A211S A 211 0 0 0 NA Non_Hotspot 8%
A211T A 211 0 0 0 NA Non_Hotspot 8.9%
A211V A 211 0 0 0 NA Non_Hotspot 9.8%
A217D A 217 0 0 0 NA Non_Hotspot 12.2%
A217G A 217 0 0 0 NA Non_Hotspot 12.2%
A217P A 217 0 0 0 NA Non_Hotspot 8%
A217S A 217 0 0 0 NA Non_Hotspot 6.5%
A217T A 217 0 0 0 NA Non_Hotspot 9.9%
A217V A 217 0 0 0 NA Non_Hotspot 12.1%
A223E A 223 0 0 0 NA Non_Hotspot 9%
A223G A 223 0 0 0 NA Non_Hotspot 10%
A223P A 223 0 0 0 NA Non_Hotspot 9.9%
A223S A 223 0 0 0 NA Non_Hotspot 9%
A223T A 223 0 0 0 NA Non_Hotspot 10%
A223V A 223 0 0 0 NA Non_Hotspot 11.1%
A228E A 228 0 0 0 NA Mild_Hotspot 13.7%
A228G A 228 0 0 0 NA Mild_Hotspot 15.1%
A228P A 228 2 0 2 NA Mild_Hotspot 9.3%
A228S A 228 0 0 0 NA Mild_Hotspot 12.4%
A228T A 228 1 0 1 NA Mild_Hotspot 12.3%
A228V A 228 2 1 1 NA Mild_Hotspot 19.7%
A233E A 233 0 0 0 NA Mild_Hotspot 11.7%
A233G A 233 0 0 0 NA Mild_Hotspot 13.2%
A233P A 233 0 0 0 NA Mild_Hotspot 13%
A233S A 233 18 0 18 NA Mild_Hotspot 3.8%
A233T A 233 0 0 0 NA Mild_Hotspot 10.7%
A233V A 233 0 0 0 NA Mild_Hotspot 13.1%
A244E A 244 4 0 4 NA Non_Hotspot 6.2%
A244G A 244 2 0 2 NA Non_Hotspot 8%
A244P A 244 0 0 0 NA Non_Hotspot 7%
A244S A 244 0 0 0 NA Non_Hotspot 7.1%
A244T A 244 0 0 0 NA Non_Hotspot 8.8%
A244V A 244 0 0 0 NA Non_Hotspot 8.8%
A253E A 253 0 0 0 NA Non_Hotspot 9.2%
A253G A 253 0 0 0 NA Non_Hotspot 9.3%
A253P A 253 0 0 0 NA Non_Hotspot 6.7%
A253S A 253 0 0 0 NA Non_Hotspot 8.4%
A253T A 253 0 0 0 NA Non_Hotspot 8.4%
A253V A 253 0 0 0 NA Non_Hotspot 8.3%
A260D A 260 0 0 0 NA Non_Hotspot 8.9%
A260G A 260 0 0 0 NA Non_Hotspot 6.5%
A260P A 260 0 0 0 NA Non_Hotspot 8.1%
A260S A 260 0 0 0 NA Non_Hotspot 7.3%
A260T A 260 0 0 0 NA Non_Hotspot 7.2%
A260V A 260 1 0 1 NA Non_Hotspot 7.2%
A268D A 268 0 0 0 NA Non_Hotspot 9%
A268G A 268 0 0 0 NA Non_Hotspot 9%
A268P A 268 0 0 0 NA Non_Hotspot 8.1%
A268S A 268 0 0 0 NA Non_Hotspot 5.9%
A268T A 268 0 0 0 NA Non_Hotspot 5.2%
A268V A 268 0 0 0 NA Non_Hotspot 8.1%
A277D A 277 0 0 0 NA Non_Hotspot 9.9%
A277G A 277 0 0 0 NA Non_Hotspot 10%
A277P A 277 0 0 0 NA Non_Hotspot 9.9%
A277S A 277 0 0 0 NA Non_Hotspot 9%
A277T A 277 0 0 0 NA Non_Hotspot 8.9%
A277V A 277 0 0 0 NA Non_Hotspot 9.9%
A282D A 282 0 0 0 NA Non_Hotspot 10.3%
A282G A 282 0 0 0 NA Non_Hotspot 8.4%
A282P A 282 0 0 0 NA Non_Hotspot 9.3%
A282S A 282 0 0 0 NA Non_Hotspot 6.1%
A282T A 282 0 0 0 NA Non_Hotspot 8.4%
A282V A 282 0 0 0 NA Non_Hotspot 6.8%
A285D A 285 0 0 0 NA Non_Hotspot 10.1%
A285G A 285 0 0 0 NA Non_Hotspot 10.2%
A285P A 285 0 0 0 NA Non_Hotspot 8.2%
A285S A 285 0 0 0 NA Non_Hotspot 9.1%
A285T A 285 0 0 0 NA Non_Hotspot 6.6%
A285V A 285 1 0 1 NA Non_Hotspot 4%
A290D A 290 0 0 0 NA Non_Hotspot 10.5%
A290G A 290 0 0 0 NA Non_Hotspot 8.5%
A290P A 290 0 0 0 NA Non_Hotspot 12.9%
A290S A 290 0 0 0 NA Non_Hotspot 9.5%
A290T A 290 0 0 0 NA Non_Hotspot 9.5%
A290V A 290 0 0 0 NA Non_Hotspot 11.6%
A293D A 293 0 0 0 NA Non_Hotspot 10.3%
A293G A 293 0 0 0 NA Non_Hotspot 7.5%
A293P A 293 0 0 0 NA Non_Hotspot 8.3%
A293S A 293 0 0 0 NA Non_Hotspot 8.3%
A293T A 293 0 0 0 NA Non_Hotspot 9.2%
A293V A 293 0 0 0 NA Non_Hotspot 10.3%
A303D A 303 0 0 0 NA Non_Hotspot 11.4%
A303G A 303 0 0 0 NA Non_Hotspot 9.3%
A303P A 303 0 0 0 NA Non_Hotspot 11.4%
A303S A 303 0 0 0 NA Non_Hotspot 7.6%
A303T A 303 0 0 0 NA Non_Hotspot 10.3%
A303V A 303 0 0 0 NA Non_Hotspot 11.4%
A307D A 307 0 0 0 NA Non_Hotspot 12.9%
A307G A 307 0 0 0 NA Non_Hotspot 9.5%
A307P A 307 2 0 2 NA Non_Hotspot 6.5%
A307S A 307 0 0 0 NA Non_Hotspot 10.5%
A307T A 307 0 0 0 NA Non_Hotspot 10.5%
A307V A 307 0 0 0 NA Non_Hotspot 11.7%
A32D A 32 0 0 0 NA Hotspot 77%
A32G A 32 0 0 0 NA Hotspot 70.6%
A32P A 32 0 0 0 NA Hotspot 74.9%
A32S A 32 0 0 0 NA Hotspot 70.5%
A32T A 32 1 1 0 NA Hotspot 75%
A32V A 32 0 0 0 NA Hotspot 72.8%
A34D A 34 0 0 0 NA Hotspot 65.8%
A34G A 34 0 0 0 NA Hotspot 60.5%
A34P A 34 0 0 0 NA Hotspot 63.2%
A34S A 34 0 0 0 NA Hotspot 57.7%
A34T A 34 1 0 1 NA Hotspot 54.7%
A34V A 34 0 0 0 NA Hotspot 60.6%
A350D A 350 0 0 0 NA Non_Hotspot 9.1%
A350G A 350 0 0 0 NA Non_Hotspot 7.4%
A350P A 350 0 0 0 NA Non_Hotspot 6.1%
A350S A 350 0 0 0 NA Non_Hotspot 6%
A350T A 350 0 0 0 NA Non_Hotspot 6%
A350V A 350 0 0 0 NA Non_Hotspot 8.2%
A360E A 360 0 0 0 NA Non_Hotspot 9.8%
A360G A 360 0 0 0 NA Non_Hotspot 8.9%
A360P A 360 0 0 0 NA Non_Hotspot 7.2%
A360S A 360 0 0 0 NA Non_Hotspot 8%
A360T A 360 0 0 0 NA Non_Hotspot 8.9%
A360V A 360 0 0 0 NA Non_Hotspot 9.8%
A382D A 382 0 0 0 NA Hotspot 38%
A382G A 382 0 0 0 NA Hotspot 35.3%
A382P A 382 0 0 0 NA Hotspot 35.1%
A382S A 382 0 0 0 NA Hotspot 32.8%
A382T A 382 2 1 1 NA Hotspot 37.5%
A382V A 382 0 0 0 NA Hotspot 35.1%
A392E A 392 0 0 0 NA Non_Hotspot 8.8%
A392G A 392 0 0 0 NA Non_Hotspot 8%
A392P A 392 0 0 0 NA Non_Hotspot 8.8%
A392S A 392 0 0 0 NA Non_Hotspot 7.2%
A392T A 392 0 0 0 NA Non_Hotspot 6.5%
A392V A 392 0 0 0 NA Non_Hotspot 8%
A408D A 408 0 0 0 NA Non_Hotspot 11.6%
A408G A 408 0 0 0 NA Non_Hotspot 9.5%
A408P A 408 0 0 0 NA Non_Hotspot 10.4%
A408S A 408 0 0 0 NA Non_Hotspot 8.5%
A408T A 408 0 0 0 NA Non_Hotspot 9.5%
A408V A 408 0 0 0 NA Non_Hotspot 9.5%
A40D A 40 0 0 0 NA Hotspot 50.4%
A40G A 40 0 0 0 NA Hotspot 42.5%
A40P A 40 0 0 0 NA Hotspot 47.9%
A40S A 40 0 0 0 NA Hotspot 42.2%
A40T A 40 0 0 0 NA Hotspot 44.8%
A40V A 40 0 0 0 NA Hotspot 44.8%
A422D A 422 0 0 0 NA Hotspot 80.1%
A422G A 422 0 0 0 NA Hotspot 76.3%
A422P A 422 0 0 0 NA Hotspot 78.2%
A422S A 422 0 0 0 NA Hotspot 74.1%
A422T A 422 3 3 0 Severe Dominant LOF Hotspot 83.6%
A422V A 422 0 0 0 NA Hotspot 76.2%
A429D A 429 0 0 0 NA Mild_Hotspot 34%
A429G A 429 0 0 0 NA Mild_Hotspot 29%
A429P A 429 3 2 1 Dominant LOF Mild_Hotspot 41.1%
A429S A 429 0 0 0 NA Mild_Hotspot 26.7%
A429T A 429 0 0 0 NA Mild_Hotspot 29%
A429V A 429 1 0 1 NA Mild_Hotspot 26.5%
A430D A 430 0 0 0 NA Hotspot 56%
A430G A 430 0 0 0 NA Hotspot 50.4%
A430P A 430 0 0 0 NA Hotspot 53.3%
A430S A 430 0 0 0 NA Hotspot 47.8%
A430T A 430 0 0 0 NA Hotspot 50.6%
A430V A 430 0 0 0 NA Hotspot 50.3%
A442D A 442 0 0 0 NA Mild_Hotspot 14.6%
A442G A 442 0 0 0 NA Mild_Hotspot 12%
A442P A 442 0 0 0 NA Mild_Hotspot 13.2%
A442S A 442 0 0 0 NA Mild_Hotspot 12%
A442T A 442 0 0 0 NA Mild_Hotspot 13.2%
A442V A 442 0 0 0 NA Mild_Hotspot 13.3%
A448D A 448 0 0 0 NA Hotspot 41.7%
A448G A 448 0 0 0 NA Hotspot 39%
A448P A 448 0 0 0 NA Hotspot 36.2%
A448S A 448 34 0 34 NA Hotspot 6.9%
A448T A 448 1 1 0 NA Hotspot 42.1%
A448V A 448 0 0 0 NA Hotspot 41.6%
A453D A 453 0 0 0 NA Hotspot 66.5%
A453G A 453 0 0 0 NA Hotspot 66.4%
A453P A 453 0 0 0 NA Hotspot 71.2%
A453S A 453 0 0 0 NA Hotspot 63.9%
A453T A 453 0 0 0 NA Hotspot 66.4%
A453V A 453 0 0 0 NA Hotspot 71.3%
A478D A 478 1 0 1 NA Mild_Hotspot 13.7%
A478G A 478 0 0 0 NA Mild_Hotspot 15.2%
A478P A 478 0 0 0 NA Mild_Hotspot 15.1%
A478S A 478 0 0 0 NA Mild_Hotspot 11.2%
A478T A 478 0 0 0 NA Mild_Hotspot 12.4%
A478V A 478 0 0 0 NA Mild_Hotspot 13.7%
A490D A 490 0 0 0 NA Hotspot 67.3%
A490G A 490 0 0 0 NA Hotspot 62.2%
A490P A 490 5 5 0 NA Hotspot 76.4%
A490S A 490 0 0 0 NA Hotspot 59.4%
A490T A 490 12 7 5 Severe Dominant LOF Hotspot 62.4%
A490V A 490 0 0 0 NA Hotspot 62.1%
A504D A 504 0 0 0 NA Hotspot 44.6%
A504G A 504 0 0 0 NA Hotspot 39%
A504P A 504 0 0 0 NA Hotspot 41.7%
A504S A 504 0 0 0 NA Hotspot 36.5%
A504T A 504 0 0 0 NA Hotspot 39%
A504V A 504 2 1 1 NA Hotspot 40.9%
A505D A 505 0 0 0 NA Mild_Hotspot 22.8%
A505G A 505 0 0 0 NA Mild_Hotspot 19%
A505P A 505 0 0 0 NA Mild_Hotspot 20.8%
A505S A 505 0 0 0 NA Mild_Hotspot 17.4%
A505T A 505 0 0 0 NA Mild_Hotspot 19.1%
A505V A 505 1 0 1 NA Mild_Hotspot 17.3%
A527E A 527 0 0 0 NA Hotspot 38.9%
A527G A 527 0 0 0 NA Hotspot 36.3%
A527P A 527 0 0 0 NA Hotspot 38.9%
A527S A 527 0 0 0 NA Hotspot 33.7%
A527T A 527 0 0 0 NA Hotspot 36.3%
A527V A 527 0 0 0 NA Hotspot 36.4%
A527W A 527 0 0 0 NA Hotspot 50.6%
A536E A 536 0 0 0 NA Hotspot 37%
A536G A 536 0 0 0 NA Hotspot 34.8%
A536P A 536 0 0 0 NA Hotspot 34.3%
A536S A 536 0 0 0 NA Hotspot 32%
A536T A 536 0 0 0 NA Hotspot 34.5%
A536V A 536 0 0 0 NA Hotspot 34.7%
A536W A 536 0 0 0 NA Hotspot 48.6%
A547E A 547 0 0 0 NA Non_Hotspot 8.7%
A547G A 547 0 0 0 NA Non_Hotspot 7.8%
A547P A 547 0 0 0 NA Non_Hotspot 8.7%
A547S A 547 0 0 0 NA Non_Hotspot 7%
A547T A 547 2 0 2 NA Non_Hotspot 6.5%
A547V A 547 0 0 0 NA Non_Hotspot 7.8%
A548D A 548 0 0 0 NA Non_Hotspot 11.8%
A548G A 548 0 0 0 NA Non_Hotspot 9.7%
A548P A 548 0 0 0 NA Non_Hotspot 10.7%
A548S A 548 0 0 0 NA Non_Hotspot 8.8%
A548T A 548 0 0 0 NA Non_Hotspot 9.8%
A548V A 548 0 0 0 NA Non_Hotspot 9.7%
A558E A 558 3 3 0 NA Hotspot 69.9%
A558G A 558 0 0 0 NA Hotspot 58.4%
A558P A 558 7 6 1 Dominant LOF Hotspot 71.6%
A558S A 558 0 0 0 NA Hotspot 55.6%
A558T A 558 0 0 0 NA Hotspot 58.3%
A558V A 558 3 0 3 NA Hotspot 44.9%
A561E A 561 0 0 0 NA Hotspot 71%
A561G A 561 0 0 0 NA Hotspot 68.7%
A561Ins A 561 0 0 0 NA Hotspot 71%
A561P A 561 1 1 0 Dominant LOF Hotspot 72.3%
A561S A 561 0 0 0 NA Hotspot 66.1%
A561T A 561 28 25 3 NA Hotspot 83.9%
A561V A 561 39 35 4 Severe Dominant LOF Hotspot 86.2%
A565D A 565 0 0 0 NA Hotspot 60.7%
A565G A 565 0 0 0 NA Hotspot 55.3%
A565P A 565 0 0 0 NA Hotspot 57.8%
A565S A 565 0 0 0 NA Hotspot 52.3%
A565T A 565 0 0 0 NA Hotspot 55%
A565V A 565 0 0 0 NA Hotspot 55.3%
A570D A 570 0 0 0 NA Hotspot 70.3%
A570G A 570 0 0 0 NA Hotspot 65.3%
A570P A 570 0 0 0 NA Hotspot 67.9%
A570S A 570 0 0 0 NA Hotspot 62.8%
A570T A 570 0 0 0 NA Hotspot 65.3%
A570V A 570 0 0 0 NA Hotspot 65.4%
A57D A 57 0 0 0 NA Hotspot 77.7%
A57G A 57 0 0 0 NA Hotspot 73.7%
A57P A 57 1 1 0 NA Hotspot 65%
A57S A 57 0 0 0 NA Hotspot 69%
A57T A 57 0 0 0 NA Hotspot 73.7%
A57V A 57 0 0 0 NA Hotspot 71.3%
A614E A 614 0 0 0 NA Hotspot 79.2%
A614G A 614 0 0 0 NA Hotspot 77.4%
A614P A 614 0 0 0 NA Hotspot 79.3%
A614S A 614 0 0 0 NA Hotspot 75.4%
A614T A 614 5 5 0 NA Hotspot 84.8%
A614V A 614 49 48 1 Dominant LOF Hotspot 94.5%
A653C A 653 0 0 0 NA Hotspot 52.6%
A653D A 653 0 0 0 NA Hotspot 51.8%
A653G A 653 0 0 0 NA Hotspot 46.2%
A653I A 653 0 0 0 NA Hotspot 51.4%
A653M A 653 0 0 0 NA Hotspot 51.4%
A653P A 653 0 0 0 NA Hotspot 48.9%
A653S A 653 0 0 0 NA Hotspot 43.2%
A653T A 653 0 0 0 NA Hotspot 46%
A653V A 653 0 0 0 NA Hotspot 46.1%
A653Y A 653 0 0 0 NA Hotspot 54.9%
A661C A 661 0 0 0 NA Mild_Hotspot 15%
A661D A 661 0 0 0 NA Mild_Hotspot 14.3%
A661G A 661 0 0 0 NA Mild_Hotspot 11.7%
A661P A 661 0 0 0 NA Mild_Hotspot 12.9%
A661S A 661 0 0 0 NA Mild_Hotspot 10.6%
A661T A 661 0 0 0 NA Mild_Hotspot 11.8%
A661V A 661 1 0 1 NA Mild_Hotspot 10.7%
A671D A 671 0 0 0 NA Mild_Hotspot 29.1%
A671Del A 671 1 1 0 NA Mild_Hotspot 34.9%
A671G A 671 1 0 1 NA Mild_Hotspot 22.4%
A671P A 671 0 0 0 NA Mild_Hotspot 26.8%
A671S A 671 0 0 0 NA Mild_Hotspot 22.7%
A671T A 671 0 0 0 NA Mild_Hotspot 24.7%
A671V A 671 0 0 0 NA Mild_Hotspot 24.7%
A704D A 704 0 0 0 NA Non_Hotspot 11.5%
A704G A 704 0 0 0 NA Non_Hotspot 9.3%
A704P A 704 0 0 0 NA Non_Hotspot 10.3%
A704S A 704 0 0 0 NA Non_Hotspot 8.5%
A704T A 704 1 0 1 NA Non_Hotspot 8.5%
A704V A 704 1 0 1 NA Non_Hotspot 8.5%
A715E A 715 0 0 0 NA Mild_Hotspot 15.3%
A715G A 715 0 0 0 NA Mild_Hotspot 13.7%
A715P A 715 0 0 0 NA Mild_Hotspot 15.1%
A715S A 715 0 0 0 NA Mild_Hotspot 12.6%
A715T A 715 1 0 1 NA Mild_Hotspot 12.5%
A715V A 715 8 0 8 NA Mild_Hotspot 7.6%
A726D A 726 0 0 0 NA Mild_Hotspot 17.2%
A726G A 726 0 0 0 NA Mild_Hotspot 14.3%
A726P A 726 0 0 0 NA Mild_Hotspot 15.6%
A726S A 726 0 0 0 NA Mild_Hotspot 12.9%
A726T A 726 0 0 0 NA Mild_Hotspot 14.2%
A726V A 726 0 0 0 NA Mild_Hotspot 14.2%
A746D A 746 0 0 0 NA Non_Hotspot 9.6%
A746G A 746 0 0 0 NA Non_Hotspot 8.8%
A746P A 746 0 0 0 NA Non_Hotspot 9.6%
A746S A 746 3 0 3 NA Non_Hotspot 4.9%
A746T A 746 0 0 0 NA Non_Hotspot 8.7%
A746V A 746 0 0 0 NA Non_Hotspot 9.7%
A753D A 753 0 0 0 NA Mild_Hotspot 17.1%
A753G A 753 0 0 0 NA Mild_Hotspot 14.1%
A753P A 753 0 0 0 NA Mild_Hotspot 15.4%
A753S A 753 1 0 1 NA Mild_Hotspot 11.5%
A753T A 753 0 0 0 NA Mild_Hotspot 14.1%
A753V A 753 0 0 0 NA Mild_Hotspot 14.1%
A755D A 755 0 0 0 NA Mild_Hotspot 16.5%
A755G A 755 0 0 0 NA Mild_Hotspot 13.6%
A755P A 755 0 0 0 NA Mild_Hotspot 14.9%
A755S A 755 0 0 0 NA Mild_Hotspot 12.4%
A755T A 755 0 0 0 NA Mild_Hotspot 13.5%
A755V A 755 0 0 0 NA Mild_Hotspot 13.6%
A763E A 763 0 0 0 NA Mild_Hotspot 28.3%
A763G A 763 0 0 0 NA Mild_Hotspot 26.2%
A763P A 763 0 0 0 NA Mild_Hotspot 28.3%
A763S A 763 0 0 0 NA Mild_Hotspot 24.1%
A763T A 763 0 0 0 NA Mild_Hotspot 26.1%
A763V A 763 0 0 0 NA Mild_Hotspot 26.3%
A772D A 772 0 0 0 NA Hotspot 47.6%
A772G A 772 0 0 0 NA Hotspot 42.1%
A772P A 772 0 0 0 NA Hotspot 44.7%
A772S A 772 0 0 0 NA Hotspot 39.4%
A772T A 772 0 0 0 NA Hotspot 42.1%
A772V A 772 0 0 0 NA Hotspot 42%
A778D A 778 0 0 0 NA Mild_Hotspot 20.8%
A778G A 778 0 0 0 NA Mild_Hotspot 17.5%
A778P A 778 0 0 0 NA Mild_Hotspot 19%
A778S A 778 0 0 0 NA Mild_Hotspot 16%
A778T A 778 1 0 1 NA Mild_Hotspot 15.8%
A778V A 778 0 0 0 NA Mild_Hotspot 17.4%
A78D A 78 0 0 0 NA Hotspot 56.1%
A78G A 78 0 0 0 NA Hotspot 61.8%
A78P A 78 4 3 1 NA Hotspot 67.2%
A78S A 78 0 0 0 NA Hotspot 59.3%
A78T A 78 1 1 0 NA Hotspot 66.2%
A78V A 78 0 0 0 NA Hotspot 63.8%
A797D A 797 0 0 0 NA Hotspot 69.8%
A797G A 797 0 0 0 NA Hotspot 65.1%
A797P A 797 0 0 0 NA Hotspot 67.2%
A797S A 797 0 0 0 NA Hotspot 62.2%
A797T A 797 2 2 0 NA Hotspot 70.5%
A797V A 797 0 0 0 NA Hotspot 64.9%
A79D A 79 0 0 0 NA Hotspot 57.5%
A79Del A 79 1 1 0 NA Hotspot 56.2%
A79G A 79 0 0 0 NA Hotspot 54.8%
A79P A 79 0 0 0 NA Hotspot 54.4%
A79S A 79 3 1 2 NA Hotspot 47%
A79T A 79 1 0 1 NA Hotspot 44.2%
A79V A 79 0 0 0 NA Hotspot 40.6%
A80E A 80 0 0 0 NA Hotspot 62.5%
A80G A 80 0 0 0 NA Hotspot 60.1%
A80P A 80 1 1 0 LOF Hotspot 63.4%
A80S A 80 0 0 0 NA Hotspot 57.3%
A80T A 80 0 0 0 NA Hotspot 60.1%
A80V A 80 0 0 0 NA Hotspot 59.5%
A813E A 813 0 0 0 NA Mild_Hotspot 17.3%
A813G A 813 0 0 0 NA Mild_Hotspot 15.7%
A813P A 813 0 0 0 NA Mild_Hotspot 15.6%
A813S A 813 0 0 0 NA Mild_Hotspot 14.2%
A813T A 813 0 0 0 NA Mild_Hotspot 15.7%
A813V A 813 0 0 0 NA Mild_Hotspot 15.7%
A824D A 824 0 0 0 NA Hotspot 56.4%
A824G A 824 0 0 0 NA Hotspot 50.7%
A824P A 824 0 0 0 NA Hotspot 53.6%
A824S A 824 0 0 0 NA Hotspot 48%
A824T A 824 0 0 0 NA Hotspot 50.8%
A824V A 824 0 0 0 NA Hotspot 50.7%
A83E A 83 0 0 0 NA Hotspot 44.1%
A83G A 83 0 0 0 NA Hotspot 41.7%
A83P A 83 1 0 1 NA Hotspot 39.7%
A83S A 83 0 0 0 NA Hotspot 38.8%
A83T A 83 0 0 0 NA Hotspot 38.8%
A83V A 83 0 0 0 NA Hotspot 41.4%
A85E A 85 0 0 0 NA Hotspot 68.8%
A85G A 85 0 0 0 NA Hotspot 66.6%
A85P A 85 2 2 0 NA Hotspot 73.8%
A85S A 85 0 0 0 NA Hotspot 63.9%
A85T A 85 0 0 0 NA Hotspot 66.3%
A85V A 85 1 1 0 NA Hotspot 69.3%
A89D A 89 0 0 0 NA Mild_Hotspot 13.6%
A89G A 89 1 0 1 NA Mild_Hotspot 12.3%
A89P A 89 0 0 0 NA Mild_Hotspot 13.5%
A89S A 89 0 0 0 NA Mild_Hotspot 8.1%
A89T A 89 0 0 0 NA Mild_Hotspot 10%
A89V A 89 1 0 1 NA Mild_Hotspot 12.2%
A907D A 907 0 0 0 NA Non_Hotspot 7.8%
A907G A 907 0 0 0 NA Non_Hotspot 7.9%
A907P A 907 0 0 0 NA Non_Hotspot 7.8%
A907S A 907 0 0 0 NA Non_Hotspot 7.1%
A907T A 907 0 0 0 NA Non_Hotspot 7.1%
A907V A 907 0 0 0 NA Non_Hotspot 7.9%
A913E A 913 0 0 0 NA Non_Hotspot 8.7%
A913G A 913 0 0 0 NA Non_Hotspot 9.7%
A913P A 913 0 0 0 NA Non_Hotspot 10.7%
A913S A 913 0 0 0 NA Non_Hotspot 8.8%
A913T A 913 0 0 0 NA Non_Hotspot 9.8%
A913V A 913 83 5 78 NA Non_Hotspot 6.4%
A915E A 915 0 0 0 NA Non_Hotspot 7.7%
A915G A 915 0 0 0 NA Non_Hotspot 8.5%
A915P A 915 0 0 0 NA Non_Hotspot 8.5%
A915S A 915 0 0 0 NA Non_Hotspot 7.7%
A915T A 915 0 0 0 NA Non_Hotspot 8.6%
A915V A 915 6 0 6 NA Non_Hotspot 5.8%
A97D A 97 0 0 0 NA Hotspot 53.7%
A97G A 97 0 0 0 NA Hotspot 57.2%
A97P A 97 0 0 0 NA Hotspot 56.7%
A97S A 97 0 0 0 NA Hotspot 48.6%
A97T A 97 0 0 0 NA Hotspot 48.8%
A97V A 97 0 0 0 NA Hotspot 54.3%
A990D A 990 0 0 0 NA Non_Hotspot 9.2%
A990G A 990 0 0 0 NA Non_Hotspot 8.3%
A990P A 990 0 0 0 NA Non_Hotspot 9.3%
A990S A 990 0 0 0 NA Non_Hotspot 6.8%
A990T A 990 6 0 6 NA Non_Hotspot 4.2%
A990V A 990 0 0 0 NA Non_Hotspot 8.3%
A9E A 9 0 0 0 NA Non_Hotspot 10.2%
A9G A 9 0 0 0 NA Non_Hotspot 9.2%
A9P A 9 0 0 0 NA Non_Hotspot 10.3%
A9S A 9 0 0 0 NA Non_Hotspot 8.4%
A9T A 9 1 0 1 NA Non_Hotspot 8.3%
A9V A 9 5 0 5 NA Non_Hotspot 6.1%
C1015F A 1015 0 0 0 NA Non_Hotspot 10%
C1015G A 1015 0 0 0 NA Non_Hotspot 8%
C1015R A 1015 0 0 0 NA Non_Hotspot 7.3%
C1015S A 1015 0 0 0 NA Non_Hotspot 6.5%
C1015W A 1015 0 0 0 NA Non_Hotspot 9.9%
C1015Y A 1015 1 0 1 NA Non_Hotspot 8.1%
C105F A 105 0 0 0 NA Hotspot 80.6%
C105G A 105 0 0 0 NA Hotspot 78.7%
C105R A 105 0 0 0 NA Hotspot 80.5%
C105S A 105 0 0 0 NA Hotspot 74.7%
C105W A 105 0 0 0 NA Hotspot 80.5%
C105Y A 105 0 0 0 NA Hotspot 80.5%
C108F A 108 0 0 0 NA Hotspot 61.5%
C108G A 108 0 0 0 NA Hotspot 61.5%
C108R A 108 0 0 0 NA Hotspot 64%
C108S A 108 0 0 0 NA Hotspot 59%
C108W A 108 0 0 0 NA Hotspot 61.6%
C108Y A 108 4 3 1 NA Hotspot 65.1%
C1117F A 1117 0 0 0 NA Non_Hotspot 6.2%
C1117G A 1117 0 0 0 NA Non_Hotspot 12.8%
C1117R A 1117 0 0 0 NA Non_Hotspot 12.8%
C1117S A 1117 0 0 0 NA Non_Hotspot 10.4%
C1117W A 1117 0 0 0 NA Non_Hotspot 11.5%
C1117Y A 1117 0 0 0 NA Non_Hotspot 9.4%
C265F A 265 0 0 0 NA Non_Hotspot 9.9%
C265G A 265 0 0 0 NA Non_Hotspot 8.9%
C265R A 265 0 0 0 NA Non_Hotspot 11%
C265S A 265 0 0 0 NA Non_Hotspot 6.5%
C265W A 265 0 0 0 NA Non_Hotspot 5.2%
C265Y A 265 0 0 0 NA Non_Hotspot 9.9%
C276F A 276 0 0 0 NA Non_Hotspot 4.2%
C276G A 276 0 0 0 NA Non_Hotspot 11%
C276R A 276 0 0 0 NA Non_Hotspot 11%
C276S A 276 0 0 0 NA Non_Hotspot 9.9%
C276W A 276 0 0 0 NA Non_Hotspot 8.9%
C276Y A 276 0 0 0 NA Non_Hotspot 7.2%
C39F A 39 0 0 0 NA Mild_Hotspot 37.5%
C39G A 39 0 0 0 NA Mild_Hotspot 37.3%
C39R A 39 6 0 6 NA Mild_Hotspot 24.9%
C39S A 39 0 0 0 NA Mild_Hotspot 32%
C39W A 39 0 0 0 NA Mild_Hotspot 37.6%
C39Y A 39 0 0 0 NA Mild_Hotspot 37.4%
C445F A 445 0 0 0 NA Mild_Hotspot 34.6%
C445G A 445 0 0 0 NA Mild_Hotspot 34.6%
C445R A 445 0 0 0 NA Mild_Hotspot 37.3%
C445S A 445 0 0 0 NA Mild_Hotspot 29.7%
C445W A 445 0 0 0 NA Mild_Hotspot 34.8%
C445Y A 445 0 0 0 NA Mild_Hotspot 34.6%
C449F A 449 0 0 0 NA Mild_Hotspot 36.3%
C449G A 449 0 0 0 NA Mild_Hotspot 36.5%
C449R A 449 0 0 0 NA Mild_Hotspot 39.1%
C449S A 449 0 0 0 NA Mild_Hotspot 31.4%
C449W A 449 0 0 0 NA Mild_Hotspot 36.4%
C449Y A 449 0 0 0 NA Mild_Hotspot 36.4%
C44F A 44 5 2 3 NA Hotspot 61.8%
C44G A 44 0 0 0 NA Hotspot 72.1%
C44R A 44 0 0 0 NA Hotspot 74.4%
C44S A 44 0 0 0 NA Hotspot 67.3%
C44W A 44 1 1 0 NA Hotspot 75.6%
C44Y A 44 0 0 0 NA Hotspot 72.1%
C49F A 49 0 0 0 NA Hotspot 74.8%
C49G A 49 3 3 0 NA Hotspot 80.8%
C49R A 49 7 4 3 NA Hotspot 68.7%
C49S A 49 0 0 0 NA Hotspot 70.2%
C49W A 49 0 0 0 NA Hotspot 74.9%
C49Y A 49 0 0 0 NA Hotspot 74.4%
C52F A 52 0 0 0 NA Hotspot 45.4%
C52G A 52 0 0 0 NA Hotspot 59.5%
C52R A 52 0 0 0 NA Hotspot 59.6%
C52S A 52 0 0 0 NA Hotspot 51.1%
C52W A 52 11 0 11 NA Hotspot 27%
C52Y A 52 0 0 0 NA Hotspot 57%
C555A A 555 0 0 0 NA Hotspot 40.3%
C555F A 555 0 0 0 NA Hotspot 39.6%
C555G A 555 0 0 0 NA Hotspot 42.4%
C555R A 555 0 0 0 NA Hotspot 42.2%
C555S A 555 0 0 0 NA Hotspot 36.8%
C555W A 555 0 0 0 NA Hotspot 39.5%
C555Y A 555 0 0 0 NA Hotspot 42.2%
C566A A 566 0 0 0 NA Hotspot 48.1%
C566F A 566 1 1 0 NA Hotspot 55.8%
C566G A 566 2 2 0 NA Hotspot 59%
C566R A 566 1 0 1 NA Hotspot 48.4%
C566S A 566 6 1 5 NA Hotspot 34.1%
C566W A 566 0 0 0 NA Hotspot 50.3%
C566Y A 566 0 0 0 NA Hotspot 50.2%
C643A A 643 0 0 0 NA Hotspot 73.8%
C643F A 643 0 0 0 NA Hotspot 75.8%
C643G A 643 0 0 0 NA Hotspot 75.9%
C643R A 643 0 0 0 NA Hotspot 77.8%
C643S A 643 0 0 0 NA Hotspot 71.4%
C643W A 643 0 0 0 NA Hotspot 75.9%
C643Y A 643 0 0 0 NA Hotspot 75.8%
C64F A 64 0 0 0 NA Hotspot 79.5%
C64G A 64 0 0 0 NA Hotspot 79.6%
C64R A 64 1 1 0 NA Hotspot 83.1%
C64S A 64 0 0 0 NA Hotspot 73.5%
C64W A 64 0 0 0 NA Hotspot 79.6%
C64Y A 64 1 1 0 NA Hotspot 81.1%
C66F A 66 0 0 0 NA Hotspot 83%
C66G A 66 1 1 0 NA Hotspot 84.8%
C66R A 66 1 1 0 NA Hotspot 86.1%
C66S A 66 0 0 0 NA Hotspot 79.5%
C66W A 66 0 0 0 NA Hotspot 83.2%
C66Y A 66 2 2 0 NA Hotspot 85.7%
C723F A 723 0 0 0 NA Mild_Hotspot 14%
C723G A 723 1 0 1 NA Mild_Hotspot 13.1%
C723R A 723 1 0 1 NA Mild_Hotspot 14.2%
C723S A 723 0 0 0 NA Mild_Hotspot 12.7%
C723W A 723 0 0 0 NA Mild_Hotspot 14.1%
C723Y A 723 0 0 0 NA Mild_Hotspot 14%
C729F A 729 0 0 0 NA Mild_Hotspot 21.9%
C729G A 729 0 0 0 NA Mild_Hotspot 21.9%
C729R A 729 0 0 0 NA Mild_Hotspot 24%
C729S A 729 0 0 0 NA Mild_Hotspot 20.1%
C729W A 729 0 0 0 NA Mild_Hotspot 22%
C729Y A 729 0 0 0 NA Mild_Hotspot 21.9%
C740F A 740 0 0 0 NA Non_Hotspot 12.8%
C740G A 740 1 0 1 NA Non_Hotspot 11.8%
C740R A 740 0 0 0 NA Non_Hotspot 14.1%
C740S A 740 0 0 0 NA Non_Hotspot 10.5%
C740W A 740 1 0 1 NA Non_Hotspot 12.2%
C740Y A 740 0 0 0 NA Non_Hotspot 12.8%
C750F A 750 0 0 0 NA Mild_Hotspot 27.3%
C750G A 750 0 0 0 NA Mild_Hotspot 27.2%
C750R A 750 0 0 0 NA Mild_Hotspot 29.6%
C750S A 750 0 0 0 NA Mild_Hotspot 22.9%
C750W A 750 0 0 0 NA Mild_Hotspot 27.3%
C750Y A 750 0 0 0 NA Mild_Hotspot 27.3%
C828F A 828 0 0 0 NA Mild_Hotspot 33.8%
C828G A 828 0 0 0 NA Mild_Hotspot 33.8%
C828R A 828 0 0 0 NA Mild_Hotspot 36.4%
C828S A 828 0 0 0 NA Mild_Hotspot 28.9%
C828W A 828 0 0 0 NA Mild_Hotspot 34.1%
C828Y A 828 0 0 0 NA Mild_Hotspot 33.8%
C977F A 977 10 0 10 NA Mild_Hotspot 10%
C977G A 977 0 0 0 NA Mild_Hotspot 17.9%
C977R A 977 0 0 0 NA Mild_Hotspot 21.4%
C977S A 977 3 2 1 NA Mild_Hotspot 27.9%
C977W A 977 2 0 2 NA Mild_Hotspot 18.5%
C977Y A 977 1 0 1 NA Mild_Hotspot 17.7%
C984F A 984 0 0 0 NA Non_Hotspot 7%
C984G A 984 0 0 0 NA Non_Hotspot 12.9%
C984R A 984 0 0 0 NA Non_Hotspot 9.5%
C984S A 984 0 0 0 NA Non_Hotspot 7.8%
C984W A 984 0 0 0 NA Non_Hotspot 13%
C984Y A 984 0 0 0 NA Non_Hotspot 11.7%
D1003A A 1003 0 0 0 NA Non_Hotspot 9%
D1003E A 1003 0 0 0 NA Non_Hotspot 4.8%
D1003G A 1003 0 0 0 NA Non_Hotspot 8.1%
D1003H A 1003 1 0 1 NA Non_Hotspot 8.2%
D1003N A 1003 0 0 0 NA Non_Hotspot 8.2%
D1003V A 1003 0 0 0 NA Non_Hotspot 11%
D1003Y A 1003 1 0 1 NA Non_Hotspot 9.3%
D102A A 102 0 0 0 NA Hotspot 71.7%
D102E A 102 0 0 0 NA Hotspot 67.4%
D102G A 102 0 0 0 NA Hotspot 67%
D102H A 102 1 1 0 NA Hotspot 74.3%
D102N A 102 0 0 0 NA Hotspot 64.9%
D102V A 102 4 2 2 NA Hotspot 68.8%
D102Y A 102 0 0 0 NA Hotspot 73.9%
D1037A A 1037 0 0 0 NA Non_Hotspot 14%
D1037E A 1037 3 0 3 NA Non_Hotspot 4.2%
D1037G A 1037 0 0 0 NA Non_Hotspot 15.4%
D1037H A 1037 0 0 0 NA Non_Hotspot 10.3%
D1037N A 1037 5 0 5 NA Non_Hotspot 7.4%
D1037V A 1037 0 0 0 NA Non_Hotspot 15.3%
D1037Y A 1037 0 0 0 NA Non_Hotspot 15.4%
D1043A A 1043 0 0 0 NA Non_Hotspot 10.5%
D1043E A 1043 0 0 0 NA Non_Hotspot 5.7%
D1043G A 1043 1 0 1 NA Non_Hotspot 10.3%
D1043H A 1043 0 0 0 NA Non_Hotspot 10.5%
D1043N A 1043 0 0 0 NA Non_Hotspot 8.7%
D1043V A 1043 0 0 0 NA Non_Hotspot 12.8%
D1043Y A 1043 0 0 0 NA Non_Hotspot 12.9%
D1059A A 1059 0 0 0 NA Non_Hotspot 10.2%
D1059E A 1059 1 0 1 NA Non_Hotspot 6.6%
D1059G A 1059 0 0 0 NA Non_Hotspot 10.2%
D1059H A 1059 0 0 0 NA Non_Hotspot 9.2%
D1059N A 1059 0 0 0 NA Non_Hotspot 7.6%
D1059V A 1059 0 0 0 NA Non_Hotspot 11.3%
D1059Y A 1059 0 0 0 NA Non_Hotspot 11.3%
D1106A A 1106 0 0 0 NA Non_Hotspot 6.6%
D1106E A 1106 0 0 0 NA Non_Hotspot 6.6%
D1106G A 1106 0 0 0 NA Non_Hotspot 9%
D1106H A 1106 0 0 0 NA Non_Hotspot 9%
D1106N A 1106 0 0 0 NA Non_Hotspot 7.3%
D1106V A 1106 0 0 0 NA Non_Hotspot 9%
D1106Y A 1106 0 0 0 NA Non_Hotspot 9%
D111A A 111 0 0 0 NA Mild_Hotspot 35.5%
D111E A 111 0 0 0 NA Mild_Hotspot 30.8%
D111G A 111 0 0 0 NA Mild_Hotspot 35.6%
D111H A 111 0 0 0 NA Mild_Hotspot 19.9%
D111N A 111 0 0 0 NA Mild_Hotspot 30.9%
D111V A 111 3 1 2 Dominant LOF Mild_Hotspot 41.4%
D111Y A 111 0 0 0 NA Mild_Hotspot 35.4%
D1156A A 1156 0 0 0 NA Non_Hotspot 13.7%
D1156E A 1156 0 0 0 NA Non_Hotspot 10.2%
D1156G A 1156 0 0 0 NA Non_Hotspot 13.7%
D1156H A 1156 0 0 0 NA Non_Hotspot 12.5%
D1156N A 1156 0 0 0 NA Non_Hotspot 9.3%
D1156V A 1156 0 0 0 NA Non_Hotspot 12.4%
D1156Y A 1156 0 0 0 NA Non_Hotspot 15.2%
D119A A 119 0 0 0 NA Non_Hotspot 10%
D119E A 119 0 0 0 NA Non_Hotspot 5.4%
D119G A 119 1 0 1 NA Non_Hotspot 8.9%
D119H A 119 13 0 13 NA Non_Hotspot 3.9%
D119N A 119 0 0 0 NA Non_Hotspot 7.3%
D119V A 119 0 0 0 NA Non_Hotspot 12.2%
D119Y A 119 0 0 0 NA Non_Hotspot 12.1%
D136A A 136 0 0 0 NA Non_Hotspot 9.3%
D136E A 136 0 0 0 NA Non_Hotspot 5.5%
D136G A 136 0 0 0 NA Non_Hotspot 9.4%
D136H A 136 0 0 0 NA Non_Hotspot 8.4%
D136N A 136 0 0 0 NA Non_Hotspot 9.4%
D136V A 136 0 0 0 NA Non_Hotspot 12.5%
D136Y A 136 0 0 0 NA Non_Hotspot 11.3%
D144A A 144 0 0 0 NA Non_Hotspot 8.2%
D144E A 144 0 0 0 NA Non_Hotspot 5.3%
D144G A 144 0 0 0 NA Non_Hotspot 8.2%
D144H A 144 0 0 0 NA Non_Hotspot 8.2%
D144N A 144 0 0 0 NA Non_Hotspot 7.4%
D144V A 144 13 0 13 NA Non_Hotspot 4%
D144Y A 144 0 0 0 NA Non_Hotspot 9.1%
D16A A 16 1 0 1 NA Mild_Hotspot 19.3%
D16E A 16 0 0 0 NA Mild_Hotspot 18.1%
D16G A 16 0 0 0 NA Mild_Hotspot 13.5%
D16H A 16 0 0 0 NA Mild_Hotspot 19.5%
D16N A 16 0 0 0 NA Mild_Hotspot 17.9%
D16V A 16 0 0 0 NA Mild_Hotspot 25.5%
D16Y A 16 0 0 0 NA Mild_Hotspot 25.4%
D197A A 197 0 0 0 NA Mild_Hotspot 23.4%
D197E A 197 0 0 0 NA Mild_Hotspot 23.5%
D197G A 197 0 0 0 NA Mild_Hotspot 27.6%
D197H A 197 0 0 0 NA Mild_Hotspot 17.6%
D197N A 197 2 0 2 NA Mild_Hotspot 19%
D197V A 197 0 0 0 NA Mild_Hotspot 27.7%
D197Y A 197 4 3 1 NA Mild_Hotspot 41.6%
D199A A 199 0 0 0 NA Mild_Hotspot 11.9%
D199E A 199 0 0 0 NA Mild_Hotspot 12%
D199G A 199 0 0 0 NA Mild_Hotspot 13.2%
D199H A 199 0 0 0 NA Mild_Hotspot 10.8%
D199N A 199 0 0 0 NA Mild_Hotspot 12.2%
D199V A 199 0 0 0 NA Mild_Hotspot 14.6%
D199Y A 199 0 0 0 NA Mild_Hotspot 14.6%
D213A A 213 0 0 0 NA Non_Hotspot 8.3%
D213E A 213 0 0 0 NA Non_Hotspot 7.6%
D213G A 213 11 0 11 NA Non_Hotspot 2.9%
D213H A 213 0 0 0 NA Non_Hotspot 9.3%
D213N A 213 0 0 0 NA Non_Hotspot 7.5%
D213V A 213 0 0 0 NA Non_Hotspot 10.2%
D213Y A 213 0 0 0 NA Non_Hotspot 10.1%
D219A A 219 0 0 0 NA Mild_Hotspot 22.4%
D219E A 219 0 0 0 NA Mild_Hotspot 17%
D219G A 219 0 0 0 NA Mild_Hotspot 26.5%
D219H A 219 0 0 0 NA Mild_Hotspot 20.5%
D219N A 219 0 0 0 NA Mild_Hotspot 20.7%
D219V A 219 3 1 2 GOF Mild_Hotspot 22.7%
D219Y A 219 0 0 0 NA Mild_Hotspot 26.4%
D259A A 259 0 0 0 NA Non_Hotspot 8.9%
D259E A 259 0 0 0 NA Non_Hotspot 5.9%
D259G A 259 0 0 0 NA Non_Hotspot 9%
D259H A 259 0 0 0 NA Non_Hotspot 6.5%
D259N A 259 1 0 1 NA Non_Hotspot 5.8%
D259V A 259 0 0 0 NA Non_Hotspot 11%
D259Y A 259 0 0 0 NA Non_Hotspot 9.9%
D286A A 286 0 0 0 NA Non_Hotspot 9.7%
D286E A 286 0 0 0 NA Non_Hotspot 7.9%
D286G A 286 0 0 0 NA Non_Hotspot 9.7%
D286H A 286 0 0 0 NA Non_Hotspot 5.2%
D286N A 286 0 0 0 NA Non_Hotspot 6.5%
D286V A 286 0 0 0 NA Non_Hotspot 11.9%
D286Y A 286 0 0 0 NA Non_Hotspot 9.8%
D287A A 287 0 0 0 NA Non_Hotspot 10.9%
D287E A 287 0 0 0 NA Non_Hotspot 7.2%
D287G A 287 0 0 0 NA Non_Hotspot 8%
D287H A 287 0 0 0 NA Non_Hotspot 10.9%
D287N A 287 0 0 0 NA Non_Hotspot 7.3%
D287V A 287 0 0 0 NA Non_Hotspot 13.3%
D287Y A 287 0 0 0 NA Non_Hotspot 12%
D321A A 321 0 0 0 NA Mild_Hotspot 17.8%
D321E A 321 0 0 0 NA Mild_Hotspot 12.2%
D321G A 321 0 0 0 NA Mild_Hotspot 16.2%
D321H A 321 0 0 0 NA Mild_Hotspot 16.2%
D321N A 321 0 0 0 NA Mild_Hotspot 12.1%
D321V A 321 0 0 0 NA Mild_Hotspot 19.5%
D321Y A 321 2 0 2 NA Mild_Hotspot 16.6%
D323A A 323 0 0 0 NA Hotspot 50.6%
D323E A 323 1 1 0 NA Hotspot 47.1%
D323G A 323 0 0 0 NA Hotspot 50.6%
D323H A 323 0 0 0 NA Hotspot 47.8%
D323N A 323 7 0 7 NA Hotspot 20.1%
D323V A 323 0 0 0 NA Hotspot 56.2%
D323Y A 323 0 0 0 NA Hotspot 53.5%
D342A A 342 1 0 1 NA Non_Hotspot 8%
D342E A 342 0 0 0 NA Non_Hotspot 6%
D342G A 342 0 0 0 NA Non_Hotspot 8.9%
D342H A 342 0 0 0 NA Non_Hotspot 8.9%
D342N A 342 0 0 0 NA Non_Hotspot 6.6%
D342V A 342 1 0 1 Dominant LOF Non_Hotspot 10.8%
D342Y A 342 0 0 0 NA Non_Hotspot 10.9%
D346A A 346 0 0 0 NA Non_Hotspot 8.9%
D346E A 346 3 0 3 NA Non_Hotspot 4.1%
D346G A 346 0 0 0 NA Non_Hotspot 7.2%
D346H A 346 0 0 0 NA Non_Hotspot 8%
D346N A 346 1 0 1 NA Non_Hotspot 6.5%
D346V A 346 0 0 0 NA Non_Hotspot 10.9%
D346Y A 346 1 0 1 NA Non_Hotspot 9.2%
D355A A 355 0 0 0 NA Non_Hotspot 6.7%
D355E A 355 0 0 0 NA Non_Hotspot 5.5%
D355G A 355 1 0 1 NA Non_Hotspot 8.3%
D355H A 355 0 0 0 NA Non_Hotspot 8.4%
D355N A 355 0 0 0 NA Non_Hotspot 7.6%
D355V A 355 0 0 0 NA Non_Hotspot 9.2%
D355Y A 355 0 0 0 NA Non_Hotspot 10.2%
D383A A 383 0 0 0 NA Mild_Hotspot 34.1%
D383E A 383 0 0 0 NA Mild_Hotspot 27.1%
D383G A 383 0 0 0 NA Mild_Hotspot 34%
D383H A 383 0 0 0 NA Mild_Hotspot 31.5%
D383N A 383 0 0 0 NA Mild_Hotspot 26.9%
D383V A 383 0 0 0 NA Mild_Hotspot 36.6%
D383Y A 383 0 0 0 NA Mild_Hotspot 36.7%
D411A A 411 0 0 0 NA Mild_Hotspot 22.4%
D411E A 411 0 0 0 NA Mild_Hotspot 17.2%
D411G A 411 0 0 0 NA Mild_Hotspot 22.6%
D411H A 411 0 0 0 NA Mild_Hotspot 20.6%
D411K A 411 0 0 0 NA Mild_Hotspot 21.8%
D411N A 411 0 0 0 NA Mild_Hotspot 17.1%
D411V A 411 0 0 0 NA Mild_Hotspot 24.7%
D411Y A 411 0 0 0 NA Mild_Hotspot 24.7%
D456A A 456 0 0 0 NA Hotspot 82.8%
D456E A 456 0 0 0 NA Hotspot 77.8%
D456G A 456 0 0 0 NA Hotspot 82.9%
D456H A 456 0 0 0 NA Hotspot 81.2%
D456N A 456 0 0 0 NA Hotspot 77.6%
D456R A 456 0 0 0 NA Hotspot 85.6%
D456V A 456 0 0 0 NA Hotspot 86%
D456Y A 456 1 1 0 Dominant LOF Hotspot 86.4%
D460A A 460 0 0 0 NA Hotspot 65.5%
D460E A 460 0 0 0 NA Hotspot 57.9%
D460G A 460 0 0 0 NA Hotspot 65.7%
D460H A 460 0 0 0 NA Hotspot 63%
D460N A 460 0 0 0 NA Hotspot 57.6%
D460V A 460 0 0 0 NA Hotspot 70.7%
D460Y A 460 0 0 0 NA Hotspot 68.2%
D466A A 466 0 0 0 NA Hotspot 58.6%
D466C A 466 0 0 0 NA Hotspot 68.1%
D466E A 466 2 1 1 NA Hotspot 50%
D466G A 466 0 0 0 NA Hotspot 58.8%
D466H A 466 0 0 0 NA Hotspot 56%
D466N A 466 0 0 0 NA Hotspot 50.3%
D466V A 466 0 0 0 NA Hotspot 64.2%
D466Y A 466 0 0 0 NA Hotspot 61.5%
D46A A 46 0 0 0 NA Hotspot 45.4%
D46E A 46 6 0 6 NA Hotspot 21.4%
D46G A 46 0 0 0 NA Hotspot 42.4%
D46H A 46 0 0 0 NA Hotspot 42.4%
D46N A 46 0 0 0 NA Hotspot 34.4%
D46V A 46 0 0 0 NA Hotspot 48.1%
D46Y A 46 3 3 0 NA Hotspot 60.6%
D501A A 501 0 0 0 NA Hotspot 73.9%
D501E A 501 0 0 0 NA Hotspot 67%
D501G A 501 0 0 0 NA Hotspot 74%
D501H A 501 1 1 0 NA Hotspot 74.4%
D501N A 501 10 7 3 NA Hotspot 68.3%
D501V A 501 0 0 0 NA Hotspot 78.2%
D501Y A 501 1 1 0 NA Hotspot 78.9%
D509A A 509 0 0 0 NA Non_Hotspot 10.3%
D509E A 509 0 0 0 NA Non_Hotspot 7.7%
D509G A 509 0 0 0 NA Non_Hotspot 10.4%
D509H A 509 0 0 0 NA Non_Hotspot 9.4%
D509N A 509 1 0 1 NA Non_Hotspot 6.8%
D509V A 509 0 0 0 NA Non_Hotspot 12.7%
D509Y A 509 0 0 0 NA Non_Hotspot 11.5%
D540A A 540 0 0 0 NA Mild_Hotspot 20.7%
D540C A 540 0 0 0 NA Mild_Hotspot 28.6%
D540E A 540 0 0 0 NA Mild_Hotspot 15.9%
D540G A 540 0 0 0 NA Mild_Hotspot 19%
D540H A 540 0 0 0 NA Mild_Hotspot 19%
D540K A 540 0 0 0 NA Mild_Hotspot 20.1%
D540N A 540 0 0 0 NA Mild_Hotspot 15.7%
D540V A 540 0 0 0 NA Mild_Hotspot 22.8%
D540Y A 540 0 0 0 NA Mild_Hotspot 22.8%
D580A A 580 0 0 0 NA Mild_Hotspot 18.5%
D580E A 580 0 0 0 NA Mild_Hotspot 16.9%
D580G A 580 0 0 0 NA Mild_Hotspot 18.3%
D580H A 580 0 0 0 NA Mild_Hotspot 20.1%
D580N A 580 0 0 0 NA Mild_Hotspot 13.9%
D580V A 580 0 0 0 NA Mild_Hotspot 22.1%
D580Y A 580 1 0 1 NA Mild_Hotspot 20.6%
D591A A 591 0 0 0 NA Mild_Hotspot 26.8%
D591E A 591 0 0 0 NA Mild_Hotspot 19%
D591G A 591 0 0 0 NA Mild_Hotspot 24.8%
D591H A 591 1 0 1 NA Mild_Hotspot 22.5%
D591N A 591 3 0 3 NA Mild_Hotspot 15.8%
D591V A 591 0 0 0 NA Mild_Hotspot 27.1%
D591Y A 591 0 0 0 NA Mild_Hotspot 29.3%
D609A A 609 0 0 0 NA Hotspot 82.7%
D609E A 609 0 0 0 NA Hotspot 77.4%
D609G A 609 3 3 0 Severe Dominant LOF Hotspot 87.9%
D609H A 609 0 0 0 NA Hotspot 81%
D609N A 609 11 10 1 NA Hotspot 84.3%
D609V A 609 0 0 0 NA Hotspot 85.8%
D609Y A 609 0 0 0 NA Hotspot 84.3%
D67A A 67 0 0 0 NA Hotspot 70.5%
D67E A 67 0 0 0 NA Hotspot 65.8%
D67G A 67 0 0 0 NA Hotspot 70.4%
D67H A 67 0 0 0 NA Hotspot 70.4%
D67N A 67 0 0 0 NA Hotspot 60.6%
D67V A 67 0 0 0 NA Hotspot 74.9%
D67Y A 67 0 0 0 NA Hotspot 75%
D712A A 712 0 0 0 NA Hotspot 56.6%
D712E A 712 0 0 0 NA Hotspot 48.2%
D712G A 712 0 0 0 NA Hotspot 56.6%
D712H A 712 0 0 0 NA Hotspot 53.7%
D712N A 712 1 1 0 NA Hotspot 52.9%
D712V A 712 0 0 0 NA Hotspot 62.2%
D712Y A 712 0 0 0 NA Hotspot 59.4%
D727A A 727 0 0 0 NA Mild_Hotspot 27%
D727E A 727 0 0 0 NA Mild_Hotspot 20.9%
D727G A 727 0 0 0 NA Mild_Hotspot 24.8%
D727H A 727 0 0 0 NA Mild_Hotspot 24.8%
D727N A 727 0 0 0 NA Mild_Hotspot 20.8%
D727V A 727 0 0 0 NA Mild_Hotspot 29.3%
D727Y A 727 0 0 0 NA Mild_Hotspot 29.4%
D767A A 767 0 0 0 NA Hotspot 49.1%
D767E A 767 0 0 0 NA Hotspot 40.8%
D767G A 767 0 0 0 NA Hotspot 49.1%
D767H A 767 0 0 0 NA Hotspot 46.2%
D767N A 767 0 0 0 NA Hotspot 40.7%
D767V A 767 0 0 0 NA Hotspot 54.9%
D767Y A 767 0 0 0 NA Hotspot 51.8%
D774A A 774 0 0 0 NA Hotspot 70%
D774E A 774 0 0 0 NA Hotspot 62.6%
D774G A 774 0 0 0 NA Hotspot 70%
D774H A 774 0 0 0 NA Hotspot 67.5%
D774N A 774 0 0 0 NA Hotspot 62.4%
D774V A 774 0 0 0 NA Hotspot 74.6%
D774Y A 774 7 7 0 NA Hotspot 84.2%
D793A A 793 0 0 0 NA Non_Hotspot 11.5%
D793E A 793 0 0 0 NA Non_Hotspot 8.5%
D793G A 793 0 0 0 NA Non_Hotspot 11.6%
D793H A 793 0 0 0 NA Non_Hotspot 10.4%
D793N A 793 2 0 2 NA Non_Hotspot 7%
D793V A 793 0 0 0 NA Non_Hotspot 14.1%
D793Y A 793 0 0 0 NA Non_Hotspot 12.7%
D803A A 803 0 0 0 NA Hotspot 52%
D803E A 803 0 0 0 NA Hotspot 43.6%
D803G A 803 0 0 0 NA Hotspot 52%
D803H A 803 0 0 0 NA Hotspot 49.1%
D803N A 803 0 0 0 NA Hotspot 43.4%
D803V A 803 0 0 0 NA Hotspot 57.7%
D803Y A 803 2 1 1 NA Hotspot 54.7%
D821A A 821 0 0 0 NA Mild_Hotspot 33.1%
D821E A 821 1 0 1 NA Mild_Hotspot 21.7%
D821G A 821 0 0 0 NA Mild_Hotspot 33%
D821H A 821 0 0 0 NA Mild_Hotspot 30.5%
D821N A 821 0 0 0 NA Mild_Hotspot 26.5%
D821V A 821 0 0 0 NA Mild_Hotspot 38.4%
D821Y A 821 0 0 0 NA Mild_Hotspot 35.8%
D829A A 829 1 0 1 NA Mild_Hotspot 12%
D829E A 829 1 0 1 NA Mild_Hotspot 8.9%
D829G A 829 0 0 0 NA Mild_Hotspot 13.3%
D829H A 829 0 0 0 NA Mild_Hotspot 12.1%
D829N A 829 0 0 0 NA Mild_Hotspot 9.9%
D829V A 829 0 0 0 NA Mild_Hotspot 16.2%
D829Y A 829 0 0 0 NA Mild_Hotspot 14.7%
D836A A 836 0 0 0 NA Hotspot 46.1%
D836E A 836 0 0 0 NA Hotspot 32.8%
D836G A 836 0 0 0 NA Hotspot 48.8%
D836H A 836 0 0 0 NA Hotspot 46%
D836N A 836 0 0 0 NA Hotspot 43.3%
D836V A 836 0 0 0 NA Hotspot 51.6%
D836Y A 836 0 0 0 NA Hotspot 51.6%
D837A A 837 0 0 0 NA Hotspot 66.9%
D837E A 837 0 0 0 NA Hotspot 56.3%
D837G A 837 1 1 0 NA Hotspot 69.7%
D837H A 837 0 0 0 NA Hotspot 64.3%
D837N A 837 13 4 9 NA Hotspot 42.8%
D837V A 837 0 0 0 NA Hotspot 71.8%
D837Y A 837 2 2 0 NA Hotspot 75.1%
D843A A 843 0 0 0 NA Hotspot 49.8%
D843E A 843 0 0 0 NA Hotspot 38.8%
D843G A 843 0 0 0 NA Hotspot 49.7%
D843H A 843 0 0 0 NA Hotspot 46.8%
D843N A 843 0 0 0 NA Hotspot 41.3%
D843V A 843 0 0 0 NA Hotspot 52.5%
D843Y A 843 0 0 0 NA Hotspot 52.4%
D850A A 850 0 0 0 NA Mild_Hotspot 14.9%
D850E A 850 0 0 0 NA Mild_Hotspot 10.1%
D850G A 850 0 0 0 NA Mild_Hotspot 14.9%
D850H A 850 0 0 0 NA Mild_Hotspot 13.6%
D850N A 850 2 0 2 NA Mild_Hotspot 9.2%
D850V A 850 0 0 0 NA Mild_Hotspot 16.4%
D850Y A 850 0 0 0 NA Mild_Hotspot 16.5%
D864A A 864 0 0 0 NA Mild_Hotspot 20.9%
D864E A 864 0 0 0 NA Mild_Hotspot 16%
D864G A 864 1 0 1 NA Mild_Hotspot 18.9%
D864H A 864 0 0 0 NA Mild_Hotspot 17.5%
D864N A 864 0 0 0 NA Mild_Hotspot 15.9%
D864V A 864 0 0 0 NA Mild_Hotspot 22.9%
D864Y A 864 0 0 0 NA Mild_Hotspot 23%
D896A A 896 0 0 0 NA Non_Hotspot 9.5%
D896E A 896 0 0 0 NA Non_Hotspot 5.7%
D896G A 896 0 0 0 NA Non_Hotspot 10.6%
D896H A 896 0 0 0 NA Non_Hotspot 9.5%
D896N A 896 0 0 0 NA Non_Hotspot 7.9%
D896V A 896 0 0 0 NA Non_Hotspot 11.7%
D896Y A 896 0 0 0 NA Non_Hotspot 11.8%
D898A A 898 0 0 0 NA Non_Hotspot 9.6%
D898E A 898 0 0 0 NA Non_Hotspot 7.1%
D898G A 898 0 0 0 NA Non_Hotspot 7.8%
D898H A 898 0 0 0 NA Non_Hotspot 8.6%
D898N A 898 0 0 0 NA Non_Hotspot 7.1%
D898V A 898 0 0 0 NA Non_Hotspot 10.7%
D898Y A 898 0 0 0 NA Non_Hotspot 10.6%
D943A A 943 0 0 0 NA Non_Hotspot 12.9%
D943E A 943 0 0 0 NA Non_Hotspot 8.6%
D943G A 943 0 0 0 NA Non_Hotspot 11.6%
D943H A 943 0 0 0 NA Non_Hotspot 11.6%
D943N A 943 0 0 0 NA Non_Hotspot 10.7%
D943V A 943 0 0 0 NA Non_Hotspot 14.1%
D943Y A 943 0 0 0 NA Non_Hotspot 14.1%
D976A A 976 0 0 0 NA Mild_Hotspot 14.8%
D976E A 976 0 0 0 NA Mild_Hotspot 12.2%
D976G A 976 0 0 0 NA Mild_Hotspot 13.4%
D976H A 976 0 0 0 NA Mild_Hotspot 13.4%
D976N A 976 0 0 0 NA Mild_Hotspot 13.6%
D976V A 976 0 0 0 NA Mild_Hotspot 16.2%
D976Y A 976 0 0 0 NA Mild_Hotspot 19.6%
D982A A 982 0 0 0 NA Non_Hotspot 10.7%
D982E A 982 0 0 0 NA Non_Hotspot 6.3%
D982G A 982 0 0 0 NA Non_Hotspot 7.8%
D982H A 982 0 0 0 NA Non_Hotspot 5.1%
D982N A 982 17 0 17 NA Non_Hotspot 1.7%
D982V A 982 0 0 0 NA Non_Hotspot 11.7%
D982Y A 982 0 0 0 NA Non_Hotspot 8.6%
E1011A A 1011 0 0 0 NA Non_Hotspot 8.2%
E1011D A 1011 0 0 0 NA Non_Hotspot 6%
E1011G A 1011 0 0 0 NA Non_Hotspot 10.1%
E1011K A 1011 1 0 1 NA Non_Hotspot 7.4%
E1011Q A 1011 0 0 0 NA Non_Hotspot 6%
E1011V A 1011 0 0 0 NA Non_Hotspot 11.1%
E1039A A 1039 0 0 0 NA Non_Hotspot 9.8%
E1039D A 1039 0 0 0 NA Non_Hotspot 7.2%
E1039G A 1039 0 0 0 NA Non_Hotspot 11%
E1039K A 1039 0 0 0 NA Non_Hotspot 10.8%
E1039Q A 1039 0 0 0 NA Non_Hotspot 9.8%
E1039V A 1039 0 0 0 NA Non_Hotspot 14.6%
E1053A A 1053 0 0 0 NA Non_Hotspot 9.3%
E1053D A 1053 0 0 0 NA Non_Hotspot 7.6%
E1053G A 1053 0 0 0 NA Non_Hotspot 10.3%
E1053K A 1053 0 0 0 NA Non_Hotspot 8.3%
E1053Q A 1053 0 0 0 NA Non_Hotspot 7.6%
E1053V A 1053 0 0 0 NA Non_Hotspot 11.4%
E1118A A 1118 0 0 0 NA Non_Hotspot 10%
E1118D A 1118 0 0 0 NA Non_Hotspot 8.2%
E1118G A 1118 0 0 0 NA Non_Hotspot 9%
E1118K A 1118 0 0 0 NA Non_Hotspot 8.1%
E1118Q A 1118 0 0 0 NA Non_Hotspot 7.3%
E1118V A 1118 0 0 0 NA Non_Hotspot 8.9%
E1119A A 1119 0 0 0 NA Non_Hotspot 8.3%
E1119D A 1119 0 0 0 NA Non_Hotspot 6%
E1119G A 1119 0 0 0 NA Non_Hotspot 9.2%
E1119K A 1119 0 0 0 NA Non_Hotspot 5.4%
E1119Q A 1119 2 0 2 NA Non_Hotspot 5.5%
E1119V A 1119 1 0 1 NA Non_Hotspot 9.2%
E1126A A 1126 0 0 0 NA Non_Hotspot 9.1%
E1126D A 1126 0 0 0 NA Non_Hotspot 6.6%
E1126G A 1126 0 0 0 NA Non_Hotspot 10.1%
E1126K A 1126 0 0 0 NA Non_Hotspot 7.4%
E1126Q A 1126 0 0 0 NA Non_Hotspot 6.7%
E1126V A 1126 0 0 0 NA Non_Hotspot 10%
E1130A A 1130 0 0 0 NA Non_Hotspot 8.6%
E1130D A 1130 0 0 0 NA Non_Hotspot 5%
E1130G A 1130 0 0 0 NA Non_Hotspot 9.6%
E1130K A 1130 0 0 0 NA Non_Hotspot 8.6%
E1130Q A 1130 0 0 0 NA Non_Hotspot 7%
E1130V A 1130 0 0 0 NA Non_Hotspot 9.6%
E118A A 118 0 0 0 NA Non_Hotspot 8.9%
E118D A 118 2 0 2 NA Non_Hotspot 6%
E118G A 118 0 0 0 NA Non_Hotspot 9.8%
E118K A 118 3 0 3 NA Non_Hotspot 5.6%
E118Q A 118 0 0 0 NA Non_Hotspot 5.2%
E118V A 118 0 0 0 NA Non_Hotspot 9.8%
E130A A 130 0 0 0 NA Mild_Hotspot 22.4%
E130D A 130 0 0 0 NA Mild_Hotspot 17.3%
E130G A 130 0 0 0 NA Mild_Hotspot 24.4%
E130K A 130 2 0 2 NA Mild_Hotspot 17%
E130Q A 130 0 0 0 NA Mild_Hotspot 17.3%
E130V A 130 0 0 0 NA Mild_Hotspot 15.4%
E134A A 134 0 0 0 NA Non_Hotspot 11.4%
E134D A 134 0 0 0 NA Non_Hotspot 6.1%
E134G A 134 0 0 0 NA Non_Hotspot 12.5%
E134K A 134 0 0 0 NA Non_Hotspot 9.2%
E134Q A 134 0 0 0 NA Non_Hotspot 6.8%
E134V A 134 0 0 0 NA Non_Hotspot 13.8%
E177A A 177 0 0 0 NA Mild_Hotspot 19.3%
E177D A 177 0 0 0 NA Mild_Hotspot 17.8%
E177G A 177 0 0 0 NA Mild_Hotspot 19.4%
E177K A 177 0 0 0 NA Mild_Hotspot 9.7%
E177Q A 177 0 0 0 NA Mild_Hotspot 14.7%
E177V A 177 0 0 0 NA Mild_Hotspot 21.2%
E208A A 208 0 0 0 NA Non_Hotspot 10.2%
E208D A 208 0 0 0 NA Non_Hotspot 5.5%
E208G A 208 0 0 0 NA Non_Hotspot 11.5%
E208K A 208 0 0 0 NA Non_Hotspot 8.4%
E208Q A 208 0 0 0 NA Non_Hotspot 8.4%
E208V A 208 0 0 0 NA Non_Hotspot 11.3%
E214A A 214 0 0 0 NA Non_Hotspot 7.7%
E214D A 214 0 0 0 NA Non_Hotspot 7.8%
E214G A 214 0 0 0 NA Non_Hotspot 9.5%
E214K A 214 0 0 0 NA Non_Hotspot 6.2%
E214Q A 214 0 0 0 NA Non_Hotspot 6.3%
E214V A 214 0 0 0 NA Non_Hotspot 10.5%
E229A A 229 0 0 0 NA Mild_Hotspot 14.7%
E229D A 229 0 0 0 NA Mild_Hotspot 8.8%
E229G A 229 0 0 0 NA Mild_Hotspot 14.7%
E229K A 229 0 0 0 NA Mild_Hotspot 13.3%
E229Q A 229 0 0 0 NA Mild_Hotspot 11%
E229V A 229 0 0 0 NA Mild_Hotspot 16.2%
E230A A 230 0 0 0 NA Non_Hotspot 11.6%
E230D A 230 1 0 1 NA Non_Hotspot 5.1%
E230G A 230 0 0 0 NA Non_Hotspot 12.8%
E230K A 230 0 0 0 NA Non_Hotspot 10.3%
E230Q A 230 0 0 0 NA Non_Hotspot 9.5%
E230V A 230 0 0 0 NA Non_Hotspot 11.5%
E23A A 23 0 0 0 NA Hotspot 70.5%
E23D A 23 0 0 0 NA Hotspot 57.5%
E23G A 23 0 0 0 NA Hotspot 72.6%
E23K A 23 0 0 0 NA Hotspot 65.3%
E23Q A 23 0 0 0 NA Hotspot 62.8%
E23V A 23 0 0 0 NA Hotspot 72.6%
E274A A 274 0 0 0 NA Non_Hotspot 8.8%
E274D A 274 0 0 0 NA Non_Hotspot 7.2%
E274G A 274 0 0 0 NA Non_Hotspot 7.2%
E274K A 274 0 0 0 NA Non_Hotspot 8%
E274Q A 274 0 0 0 NA Non_Hotspot 7.1%
E274V A 274 0 0 0 NA Non_Hotspot 10.8%
E289A A 289 0 0 0 NA Mild_Hotspot 13.2%
E289D A 289 0 0 0 NA Mild_Hotspot 10.9%
E289G A 289 0 0 0 NA Mild_Hotspot 14.6%
E289K A 289 9 1 8 NA Mild_Hotspot 10%
E289Q A 289 0 0 0 NA Mild_Hotspot 9.7%
E289V A 289 0 0 0 NA Mild_Hotspot 14.6%
E357A A 357 0 0 0 NA Non_Hotspot 8.4%
E357D A 357 5 0 5 NA Non_Hotspot 3.7%
E357G A 357 0 0 0 NA Non_Hotspot 9.3%
E357K A 357 0 0 0 NA Non_Hotspot 6.8%
E357Q A 357 0 0 0 NA Non_Hotspot 5.5%
E357V A 357 0 0 0 NA Non_Hotspot 9.3%
E365A A 365 0 0 0 NA Hotspot 55.9%
E365D A 365 0 0 0 NA Hotspot 36.5%
E365G A 365 1 1 0 NA Hotspot 59.7%
E365K A 365 0 0 0 NA Hotspot 47.3%
E365Q A 365 0 0 0 NA Hotspot 47.5%
E365R A 365 0 0 0 NA Hotspot 59.6%
E365V A 365 0 0 0 NA Hotspot 58.6%
E372A A 372 0 0 0 NA Non_Hotspot 8.9%
E372D A 372 0 0 0 NA Non_Hotspot 7.2%
E372G A 372 0 0 0 NA Non_Hotspot 11%
E372K A 372 0 0 0 NA Non_Hotspot 8.9%
E372Q A 372 0 0 0 NA Non_Hotspot 8%
E372V A 372 0 0 0 NA Non_Hotspot 10.9%
E37A A 37 0 0 0 NA Hotspot 43.2%
E37D A 37 0 0 0 NA Hotspot 37.9%
E37G A 37 0 0 0 NA Hotspot 45.7%
E37K A 37 0 0 0 NA Hotspot 37.5%
E37Q A 37 0 0 0 NA Hotspot 27.6%
E37V A 37 0 0 0 NA Hotspot 45.8%
E387A A 387 0 0 0 NA Mild_Hotspot 15.3%
E387D A 387 0 0 0 NA Mild_Hotspot 12.7%
E387G A 387 0 0 0 NA Mild_Hotspot 16.8%
E387K A 387 0 0 0 NA Mild_Hotspot 12.5%
E387Q A 387 0 0 0 NA Mild_Hotspot 11.4%
E387V A 387 0 0 0 NA Mild_Hotspot 18.5%
E435A A 435 0 0 0 NA Non_Hotspot 11%
E435D A 435 0 0 0 NA Non_Hotspot 6%
E435G A 435 2 0 2 NA Non_Hotspot 10.2%
E435K A 435 0 0 0 NA Non_Hotspot 10.1%
E435Q A 435 0 0 0 NA Non_Hotspot 9.1%
E435V A 435 0 0 0 NA Non_Hotspot 13.5%
E437A A 437 0 0 0 NA Non_Hotspot 11.1%
E437D A 437 0 0 0 NA Non_Hotspot 8.1%
E437G A 437 0 0 0 NA Non_Hotspot 12.3%
E437K A 437 0 0 0 NA Non_Hotspot 9%
E437Q A 437 0 0 0 NA Non_Hotspot 8.1%
E437V A 437 0 0 0 NA Non_Hotspot 12.3%
E438A A 438 0 0 0 NA Non_Hotspot 9.5%
E438D A 438 0 0 0 NA Non_Hotspot 6.9%
E438G A 438 0 0 0 NA Non_Hotspot 10.6%
E438K A 438 1 0 1 NA Non_Hotspot 7.1%
E438Q A 438 0 0 0 NA Non_Hotspot 6.9%
E438V A 438 0 0 0 NA Non_Hotspot 10.6%
E444A A 444 0 0 0 NA Hotspot 34.3%
E444D A 444 2 2 0 NA Hotspot 35.7%
E444G A 444 0 0 0 NA Hotspot 34.3%
E444K A 444 3 0 3 NA Hotspot 24.4%
E444Q A 444 0 0 0 NA Hotspot 29.2%
E444V A 444 0 0 0 NA Hotspot 36.9%
E480A A 480 0 0 0 NA Hotspot 65.7%
E480D A 480 0 0 0 NA Hotspot 52.6%
E480G A 480 0 0 0 NA Hotspot 68.5%
E480K A 480 0 0 0 NA Hotspot 62.9%
E480Q A 480 0 0 0 NA Hotspot 60.4%
E480V A 480 1 1 0 NA Hotspot 73.3%
E481A A 481 0 0 0 NA Hotspot 41.9%
E481D A 481 0 0 0 NA Hotspot 36.6%
E481G A 481 0 0 0 NA Hotspot 44.7%
E481K A 481 0 0 0 NA Hotspot 36.4%
E481Q A 481 0 0 0 NA Hotspot 33.8%
E481V A 481 0 0 0 NA Hotspot 47.6%
E50A A 50 0 0 0 NA Hotspot 64.9%
E50D A 50 0 0 0 NA Hotspot 64.5%
E50G A 50 0 0 0 NA Hotspot 62.4%
E50K A 50 0 0 0 NA Hotspot 65.1%
E50Q A 50 0 0 0 NA Hotspot 65.2%
E50V A 50 0 0 0 NA Hotspot 72.2%
E518A A 518 0 0 0 NA Mild_Hotspot 13.2%
E518C A 518 0 0 0 NA Mild_Hotspot 20.7%
E518D A 518 0 0 0 NA Mild_Hotspot 9%
E518G A 518 0 0 0 NA Mild_Hotspot 14.8%
E518K A 518 0 0 0 NA Mild_Hotspot 12.1%
E518Q A 518 0 0 0 NA Mild_Hotspot 9.9%
E518V A 518 0 0 0 NA Mild_Hotspot 16.2%
E519A A 519 0 0 0 NA Mild_Hotspot 12.6%
E519C A 519 0 0 0 NA Mild_Hotspot 20%
E519D A 519 0 0 0 NA Mild_Hotspot 10.4%
E519G A 519 0 0 0 NA Mild_Hotspot 14.1%
E519K A 519 0 0 0 NA Mild_Hotspot 11.5%
E519Q A 519 0 0 0 NA Mild_Hotspot 10.5%
E519V A 519 0 0 0 NA Mild_Hotspot 14%
E544A A 544 2 2 0 NA Hotspot 73%
E544D A 544 0 0 0 NA Hotspot 65.3%
E544G A 544 0 0 0 NA Hotspot 72.4%
E544K A 544 0 0 0 NA Hotspot 65.3%
E544L A 544 0 0 0 NA Hotspot 75.5%
E544Q A 544 0 0 0 NA Hotspot 62.5%
E544V A 544 0 0 0 NA Hotspot 72.4%
E575A A 575 0 0 0 NA Hotspot 79.8%
E575D A 575 0 0 0 NA Hotspot 74.1%
E575G A 575 0 0 0 NA Hotspot 81.7%
E575K A 575 1 1 0 NA Hotspot 78.5%
E575Q A 575 0 0 0 NA Hotspot 73.8%
E575V A 575 0 0 0 NA Hotspot 83.4%
E58A A 58 0 0 0 NA Hotspot 76%
E58D A 58 1 1 0 NA Hotspot 65.3%
E58G A 58 0 0 0 NA Hotspot 78%
E58K A 58 10 6 4 NA Hotspot 65.9%
E58Q A 58 0 0 0 NA Hotspot 69.3%
E58V A 58 0 0 0 NA Hotspot 80%
E637A A 637 0 0 0 NA Hotspot 82.8%
E637D A 637 0 0 0 NA Hotspot 79.5%
E637G A 637 4 4 0 Severe Dominant LOF Hotspot 90.6%
E637K A 637 5 5 0 Dominant LOF Hotspot 86.9%
E637Q A 637 0 0 0 NA Hotspot 77.3%
E637V A 637 0 0 0 NA Hotspot 85.8%
E682A A 682 0 0 0 NA Mild_Hotspot 15.9%
E682D A 682 0 0 0 NA Mild_Hotspot 13.1%
E682G A 682 0 0 0 NA Mild_Hotspot 17.5%
E682K A 682 0 0 0 NA Mild_Hotspot 13%
E682Q A 682 0 0 0 NA Mild_Hotspot 11.9%
E682V A 682 0 0 0 NA Mild_Hotspot 19.2%
E698A A 698 0 0 0 NA Non_Hotspot 8.9%
E698D A 698 0 0 0 NA Non_Hotspot 7.2%
E698G A 698 0 0 0 NA Non_Hotspot 9.8%
E698K A 698 3 0 3 NA Non_Hotspot 5.6%
E698Q A 698 0 0 0 NA Non_Hotspot 6.5%
E698V A 698 0 0 0 NA Non_Hotspot 10.9%
E699A A 699 0 0 0 NA Non_Hotspot 10.5%
E699D A 699 4 0 4 NA Non_Hotspot 6.1%
E699G A 699 0 0 0 NA Non_Hotspot 11.7%
E699K A 699 0 0 0 NA Non_Hotspot 8.5%
E699Q A 699 0 0 0 NA Non_Hotspot 7.7%
E699V A 699 0 0 0 NA Non_Hotspot 12.8%
E722A A 722 0 0 0 NA Mild_Hotspot 20.9%
E722D A 722 0 0 0 NA Mild_Hotspot 16%
E722G A 722 0 0 0 NA Mild_Hotspot 22.9%
E722K A 722 0 0 0 NA Mild_Hotspot 17.5%
E722Q A 722 0 0 0 NA Mild_Hotspot 15.8%
E722V A 722 0 0 0 NA Mild_Hotspot 22.9%
E788A A 788 0 0 0 NA Hotspot 61.9%
E788D A 788 1 1 0 NA Hotspot 60%
E788G A 788 0 0 0 NA Hotspot 64.6%
E788K A 788 2 1 1 NA Hotspot 55.7%
E788Q A 788 0 0 0 NA Hotspot 53.6%
E788V A 788 0 0 0 NA Hotspot 67.2%
E807A A 807 0 0 0 NA Hotspot 60.2%
E807D A 807 0 0 0 NA Hotspot 54.9%
E807G A 807 0 0 0 NA Hotspot 62.9%
E807K A 807 0 0 0 NA Hotspot 55.5%
E807Q A 807 0 0 0 NA Hotspot 52.2%
E807V A 807 0 0 0 NA Hotspot 65.5%
E840A A 840 0 0 0 NA Mild_Hotspot 25.4%
E840D A 840 0 0 0 NA Mild_Hotspot 21.5%
E840G A 840 0 0 0 NA Mild_Hotspot 27.6%
E840K A 840 0 0 0 NA Mild_Hotspot 21.3%
E840Q A 840 1 0 1 NA Mild_Hotspot 17.7%
E840V A 840 0 0 0 NA Mild_Hotspot 29.9%
E847A A 847 0 0 0 NA Hotspot 73.6%
E847D A 847 0 0 0 NA Hotspot 69%
E847G A 847 0 0 0 NA Hotspot 75.6%
E847K A 847 0 0 0 NA Hotspot 68.8%
E847Q A 847 0 0 0 NA Hotspot 66.3%
E847V A 847 0 0 0 NA Hotspot 77.6%
E857A A 857 0 0 0 NA Hotspot 59.3%
E857D A 857 0 0 0 NA Hotspot 54%
E857G A 857 0 0 0 NA Hotspot 62.1%
E857K A 857 0 0 0 NA Hotspot 53.8%
E857Q A 857 0 0 0 NA Hotspot 51%
E857V A 857 0 0 0 NA Hotspot 64.8%
E876A A 876 0 0 0 NA Non_Hotspot 8.9%
E876D A 876 0 0 0 NA Non_Hotspot 4.7%
E876G A 876 0 0 0 NA Non_Hotspot 9.8%
E876K A 876 0 0 0 NA Non_Hotspot 8%
E876Q A 876 0 0 0 NA Non_Hotspot 7.2%
E876V A 876 0 0 0 NA Non_Hotspot 10.9%
E878A A 878 0 0 0 NA Non_Hotspot 9%
E878D A 878 1 0 1 NA Non_Hotspot 4.8%
E878G A 878 0 0 0 NA Non_Hotspot 8.9%
E878K A 878 0 0 0 NA Non_Hotspot 8.1%
E878Q A 878 0 0 0 NA Non_Hotspot 7.3%
E878V A 878 0 0 0 NA Non_Hotspot 10.9%
E900A A 900 0 0 0 NA Non_Hotspot 7.1%
E900D A 900 0 0 0 NA Non_Hotspot 7.1%
E900G A 900 0 0 0 NA Non_Hotspot 8.7%
E900K A 900 0 0 0 NA Non_Hotspot 7.8%
E900Q A 900 0 0 0 NA Non_Hotspot 7.1%
E900V A 900 0 0 0 NA Non_Hotspot 9.6%
E904A A 904 0 0 0 NA Non_Hotspot 8.3%
E904D A 904 0 0 0 NA Non_Hotspot 6.1%
E904G A 904 0 0 0 NA Non_Hotspot 9.2%
E904K A 904 0 0 0 NA Non_Hotspot 6.7%
E904Q A 904 0 0 0 NA Non_Hotspot 6.1%
E904V A 904 0 0 0 NA Non_Hotspot 9.2%
E90A A 90 0 0 0 NA Mild_Hotspot 15.1%
E90D A 90 0 0 0 NA Mild_Hotspot 10.3%
E90G A 90 0 0 0 NA Mild_Hotspot 16.7%
E90K A 90 3 0 3 Normal Mild_Hotspot 10.3%
E90Q A 90 0 0 0 NA Mild_Hotspot 12.6%
E90V A 90 0 0 0 NA Mild_Hotspot 16.7%
E91A A 91 0 0 0 NA Mild_Hotspot 20.4%
E91D A 91 0 0 0 NA Mild_Hotspot 17.1%
E91G A 91 0 0 0 NA Mild_Hotspot 22.2%
E91K A 91 0 0 0 NA Mild_Hotspot 18.5%
E91Q A 91 0 0 0 NA Mild_Hotspot 16.9%
E91V A 91 0 0 0 NA Mild_Hotspot 24.3%
E929A A 929 0 0 0 NA Mild_Hotspot 11.3%
E929D A 929 0 0 0 NA Mild_Hotspot 10.2%
E929G A 929 0 0 0 NA Mild_Hotspot 11.3%
E929K A 929 0 0 0 NA Mild_Hotspot 11.2%
E929Q A 929 0 0 0 NA Mild_Hotspot 10.2%
E929V A 929 0 0 0 NA Mild_Hotspot 13.6%
E939A A 939 0 0 0 NA Non_Hotspot 9.5%
E939D A 939 0 0 0 NA Non_Hotspot 8.7%
E939G A 939 0 0 0 NA Non_Hotspot 11.7%
E939K A 939 0 0 0 NA Non_Hotspot 9.6%
E939Q A 939 0 0 0 NA Non_Hotspot 8.6%
E939V A 939 0 0 0 NA Non_Hotspot 11.7%
E942A A 942 0 0 0 NA Mild_Hotspot 12%
E942D A 942 0 0 0 NA Mild_Hotspot 8%
E942G A 942 0 0 0 NA Mild_Hotspot 9.8%
E942K A 942 0 0 0 NA Mild_Hotspot 10.9%
E942Q A 942 0 0 0 NA Mild_Hotspot 11%
E942V A 942 0 0 0 NA Mild_Hotspot 14.7%
E944A A 944 0 0 0 NA Non_Hotspot 11%
E944D A 944 1 0 1 NA Non_Hotspot 7.2%
E944G A 944 0 0 0 NA Non_Hotspot 11%
E944K A 944 0 0 0 NA Non_Hotspot 9%
E944Q A 944 0 0 0 NA Non_Hotspot 7.3%
E944V A 944 0 0 0 NA Non_Hotspot 12.2%
E95A A 95 0 0 0 NA Hotspot 47.8%
E95D A 95 0 0 0 NA Hotspot 39.9%
E95G A 95 1 1 0 NA Hotspot 57.4%
E95K A 95 2 0 2 NA Hotspot 37.6%
E95Q A 95 0 0 0 NA Hotspot 39.4%
E95V A 95 0 0 0 NA Hotspot 53.6%
E966A A 966 2 0 2 NA Non_Hotspot 6.7%
E966D A 966 0 0 0 NA Non_Hotspot 6.6%
E966G A 966 0 0 0 NA Non_Hotspot 9.1%
E966K A 966 3 0 3 NA Non_Hotspot 5.1%
E966Q A 966 0 0 0 NA Non_Hotspot 7.4%
E966V A 966 0 0 0 NA Non_Hotspot 8.2%
E971A A 971 0 0 0 NA Non_Hotspot 7.8%
E971D A 971 0 0 0 NA Non_Hotspot 7%
E971G A 971 0 0 0 NA Non_Hotspot 7.8%
E971K A 971 0 0 0 NA Non_Hotspot 7.8%
E971Q A 971 0 0 0 NA Non_Hotspot 7.1%
E971V A 971 0 0 0 NA Non_Hotspot 9.5%
E975A A 975 0 0 0 NA Mild_Hotspot 14.7%
E975D A 975 0 0 0 NA Mild_Hotspot 9.7%
E975G A 975 0 0 0 NA Mild_Hotspot 14.6%
E975K A 975 0 0 0 NA Mild_Hotspot 13.3%
E975Q A 975 0 0 0 NA Mild_Hotspot 12.1%
E975V A 975 0 0 0 NA Mild_Hotspot 13.2%
E978A A 978 0 0 0 NA Mild_Hotspot 12.8%
E978D A 978 0 0 0 NA Mild_Hotspot 9.4%
E978G A 978 0 0 0 NA Mild_Hotspot 15.7%
E978K A 978 66 0 66 NA Mild_Hotspot 1.4%
E978Q A 978 0 0 0 NA Mild_Hotspot 9.4%
E978V A 978 0 0 0 NA Mild_Hotspot 11.5%
F1000C A 1000 0 0 0 NA Non_Hotspot 10.4%
F1000I A 1000 0 0 0 NA Non_Hotspot 9.5%
F1000L A 1000 0 0 0 NA Non_Hotspot 8.6%
F1000S A 1000 0 0 0 NA Non_Hotspot 10.4%
F1000V A 1000 0 0 0 NA Non_Hotspot 9.5%
F1000Y A 1000 0 0 0 NA Non_Hotspot 7.8%
F106C A 106 0 0 0 NA Hotspot 84.3%
F106I A 106 0 0 0 NA Hotspot 81.2%
F106L A 106 1 1 0 NA Hotspot 81.4%
F106S A 106 0 0 0 NA Hotspot 84.3%
F106V A 106 2 2 0 NA Hotspot 85.9%
F106Y A 106 0 0 0 NA Hotspot 77.3%
F1114C A 1114 0 0 0 NA Non_Hotspot 9.4%
F1114I A 1114 0 0 0 NA Non_Hotspot 9.4%
F1114L A 1114 0 0 0 NA Non_Hotspot 9.5%
F1114S A 1114 0 0 0 NA Non_Hotspot 7.6%
F1114V A 1114 0 0 0 NA Non_Hotspot 9.4%
F1114Y A 1114 0 0 0 NA Non_Hotspot 6.2%
F125C A 125 0 0 0 NA Hotspot 49.3%
F125I A 125 0 0 0 NA Hotspot 66.8%
F125L A 125 0 0 0 NA Hotspot 64.5%
F125S A 125 0 0 0 NA Hotspot 71.7%
F125V A 125 0 0 0 NA Hotspot 66.8%
F125Y A 125 0 0 0 NA Hotspot 56.3%
F129C A 129 2 2 0 NA Hotspot 80.1%
F129I A 129 0 0 0 NA Hotspot 68.7%
F129L A 129 0 0 0 NA Hotspot 68.9%
F129S A 129 0 0 0 NA Hotspot 75.5%
F129V A 129 0 0 0 NA Hotspot 60.8%
F129Y A 129 0 0 0 NA Hotspot 60.9%
F14C A 14 0 0 0 NA Mild_Hotspot 18.1%
F14I A 14 0 0 0 NA Mild_Hotspot 15.1%
F14L A 14 0 0 0 NA Mild_Hotspot 13.8%
F14S A 14 0 0 0 NA Mild_Hotspot 18.2%
F14V A 14 0 0 0 NA Mild_Hotspot 16.7%
F14Y A 14 0 0 0 NA Mild_Hotspot 10.2%
F163C A 163 0 0 0 NA Mild_Hotspot 30%
F163I A 163 0 0 0 NA Mild_Hotspot 19.5%
F163L A 163 0 0 0 NA Mild_Hotspot 19.7%
F163S A 163 0 0 0 NA Mild_Hotspot 30.1%
F163V A 163 0 0 0 NA Mild_Hotspot 25.5%
F163Y A 163 0 0 0 NA Mild_Hotspot 19.6%
F22C A 22 0 0 0 NA Hotspot 81.7%
F22I A 22 0 0 0 NA Hotspot 78%
F22L A 22 0 0 0 NA Hotspot 76.1%
F22S A 22 1 1 0 NA Hotspot 83.4%
F22V A 22 0 0 0 NA Hotspot 79.9%
F22Y A 22 5 5 0 NA Hotspot 82.1%
F29C A 29 0 0 0 NA Hotspot 81.1%
F29I A 29 0 0 0 NA Hotspot 75.3%
F29L A 29 38 28 10 Normal Hotspot 72.8%
F29S A 29 2 2 0 NA Hotspot 84.2%
F29V A 29 1 1 0 NA Hotspot 79.7%
F29Y A 29 0 0 0 NA Hotspot 68.4%
F340C A 340 0 0 0 NA Non_Hotspot 10%
F340I A 340 0 0 0 NA Non_Hotspot 7.3%
F340L A 340 1 0 1 NA Non_Hotspot 6.1%
F340S A 340 0 0 0 NA Non_Hotspot 10%
F340V A 340 0 0 0 NA Non_Hotspot 8.1%
F340Y A 340 0 0 0 NA Non_Hotspot 5.9%
F348C A 348 0 0 0 NA Non_Hotspot 9.2%
F348I A 348 0 0 0 NA Non_Hotspot 7.5%
F348L A 348 0 0 0 NA Non_Hotspot 5.5%
F348S A 348 0 0 0 NA Non_Hotspot 9.3%
F348V A 348 0 0 0 NA Non_Hotspot 7.5%
F348Y A 348 0 0 0 NA Non_Hotspot 7.5%
F406C A 406 0 0 0 NA Mild_Hotspot 24.8%
F406I A 406 0 0 0 NA Mild_Hotspot 18.9%
F406L A 406 0 0 0 NA Mild_Hotspot 18.9%
F406S A 406 0 0 0 NA Mild_Hotspot 24.7%
F406V A 406 0 0 0 NA Mild_Hotspot 20.7%
F406Y A 406 0 0 0 NA Mild_Hotspot 14.2%
F424C A 424 0 0 0 NA Hotspot 66.1%
F424I A 424 0 0 0 NA Hotspot 61.1%
F424L A 424 0 0 0 NA Hotspot 55.5%
F424S A 424 0 0 0 NA Hotspot 68.7%
F424V A 424 0 0 0 NA Hotspot 61.1%
F424Y A 424 0 0 0 NA Hotspot 55.5%
F431C A 431 0 0 0 NA Hotspot 75.5%
F431I A 431 0 0 0 NA Hotspot 73.2%
F431L A 431 2 2 0 NA Hotspot 77.8%
F431S A 431 0 0 0 NA Hotspot 79.5%
F431V A 431 0 0 0 NA Hotspot 75.4%
F431Y A 431 0 0 0 NA Hotspot 66%
F463C A 463 0 0 0 NA Hotspot 77.1%
F463I A 463 0 0 0 NA Hotspot 70.4%
F463L A 463 8 7 1 Dominant LOF Hotspot 78.2%
F463M A 463 0 0 0 NA Hotspot 73.5%
F463S A 463 0 0 0 NA Hotspot 77.1%
F463V A 463 0 0 0 NA Hotspot 73.4%
F463W A 463 0 0 0 NA Hotspot 73.5%
F463Y A 463 0 0 0 NA Hotspot 62.8%
F471C A 471 0 0 0 NA Hotspot 74.3%
F471I A 471 0 0 0 NA Hotspot 67.2%
F471L A 471 0 0 0 NA Hotspot 67.2%
F471S A 471 0 0 0 NA Hotspot 74.3%
F471V A 471 0 0 0 NA Hotspot 69.6%
F471Y A 471 0 0 0 NA Hotspot 59.2%
F48C A 48 0 0 0 NA Hotspot 73.7%
F48I A 48 0 0 0 NA Hotspot 66.5%
F48L A 48 0 0 0 NA Hotspot 66.6%
F48S A 48 0 0 0 NA Hotspot 73.8%
F48V A 48 0 0 0 NA Hotspot 69%
F48Y A 48 0 0 0 NA Hotspot 58.6%
F494C A 494 0 0 0 NA Hotspot 83.1%
F494Del A 494 1 1 0 NA Hotspot 81.1%
F494I A 494 0 0 0 NA Hotspot 77.8%
F494L A 494 0 0 0 NA Hotspot 78.1%
F494S A 494 0 0 0 NA Hotspot 83.1%
F494V A 494 0 0 0 NA Hotspot 79.6%
F494Y A 494 0 0 0 NA Hotspot 71.2%
F498C A 498 0 0 0 NA Hotspot 69.2%
F498I A 498 0 0 0 NA Hotspot 61.4%
F498L A 498 0 0 0 NA Hotspot 61.5%
F498S A 498 0 0 0 NA Hotspot 69.2%
F498V A 498 0 0 0 NA Hotspot 64.1%
F498Y A 498 0 0 0 NA Hotspot 53.1%
F508C A 508 0 0 0 NA Hotspot 43.5%
F508I A 508 0 0 0 NA Hotspot 35.4%
F508L A 508 0 0 0 NA Hotspot 35.5%
F508S A 508 0 0 0 NA Hotspot 43.6%
F508V A 508 0 0 0 NA Hotspot 38.1%
F508Y A 508 0 0 0 NA Hotspot 28.2%
F513C A 513 0 0 0 NA Mild_Hotspot 15.1%
F513I A 513 0 0 0 NA Mild_Hotspot 12.4%
F513L A 513 0 0 0 NA Mild_Hotspot 11.2%
F513S A 513 0 0 0 NA Mild_Hotspot 13.7%
F513V A 513 0 0 0 NA Mild_Hotspot 12.4%
F513Y A 513 0 0 0 NA Mild_Hotspot 6.7%
F551C A 551 0 0 0 NA Non_Hotspot 10.4%
F551I A 551 0 0 0 NA Non_Hotspot 8.5%
F551L A 551 1 0 1 NA Non_Hotspot 7%
F551S A 551 0 0 0 NA Non_Hotspot 10.4%
F551V A 551 0 0 0 NA Non_Hotspot 8.5%
F551Y A 551 0 0 0 NA Non_Hotspot 6.9%
F557C A 557 0 0 0 NA Hotspot 65.2%
F557I A 557 0 0 0 NA Hotspot 57.1%
F557L A 557 0 0 0 NA Hotspot 57.3%
F557S A 557 0 0 0 NA Hotspot 65.2%
F557V A 557 0 0 0 NA Hotspot 59.8%
F557Y A 557 0 0 0 NA Hotspot 48.7%
F617C A 617 0 0 0 NA Hotspot 77.8%
F617I A 617 0 0 0 NA Hotspot 71.2%
F617L A 617 6 4 2 NA Hotspot 69.6%
F617S A 617 0 0 0 NA Hotspot 77.7%
F617V A 617 4 4 0 NA Hotspot 81.5%
F617Y A 617 0 0 0 NA Hotspot 63.7%
F619A A 619 0 0 0 NA Hotspot 74%
F619C A 619 0 0 0 NA Hotspot 74.1%
F619I A 619 0 0 0 NA Hotspot 67%
F619L A 619 0 0 0 NA Hotspot 67.1%
F619M A 619 0 0 0 NA Hotspot 67.1%
F619S A 619 0 0 0 NA Hotspot 74.1%
F619V A 619 0 0 0 NA Hotspot 69.5%
F619Y A 619 0 0 0 NA Hotspot 59%
F627C A 627 0 0 0 NA Hotspot 86.6%
F627I A 627 0 0 0 NA Hotspot 82.1%
F627L A 627 3 3 0 NA Hotspot 86.3%
F627S A 627 0 0 0 NA Hotspot 86.6%
F627V A 627 0 0 0 NA Hotspot 83.8%
F627Y A 627 0 0 0 NA Hotspot 76.6%
F640C A 640 0 0 0 NA Hotspot 85.6%
F640Del A 640 2 2 0 NA Hotspot 84.5%
F640I A 640 0 0 0 NA Hotspot 80%
F640L A 640 2 2 0 NA Hotspot 83.4%
F640S A 640 0 0 0 NA Hotspot 85%
F640V A 640 1 1 0 Dominant LOF Hotspot 85%
F640Y A 640 0 0 0 NA Hotspot 74.1%
F656A A 656 0 0 0 NA Hotspot 50.5%
F656C A 656 0 0 0 NA Hotspot 51.3%
F656I A 656 0 0 0 NA Hotspot 41.7%
F656L A 656 4 2 2 NA Hotspot 44.2%
F656M A 656 0 0 0 NA Hotspot 45.8%
F656S A 656 0 0 0 NA Hotspot 50.2%
F656T A 656 0 0 0 NA Hotspot 51.7%
F656V A 656 0 0 0 NA Hotspot 45%
F656Y A 656 0 0 0 NA Hotspot 33.6%
F683C A 683 0 0 0 NA Mild_Hotspot 29.6%
F683I A 683 0 0 0 NA Mild_Hotspot 22.9%
F683L A 683 0 0 0 NA Mild_Hotspot 22.9%
F683S A 683 0 0 0 NA Mild_Hotspot 29.6%
F683V A 683 0 0 0 NA Mild_Hotspot 25%
F683Y A 683 0 0 0 NA Mild_Hotspot 17.4%
F686C A 686 0 0 0 NA Mild_Hotspot 24.2%
F686I A 686 0 0 0 NA Mild_Hotspot 18.5%
F686L A 686 0 0 0 NA Mild_Hotspot 18.5%
F686S A 686 0 0 0 NA Mild_Hotspot 24.2%
F686V A 686 0 0 0 NA Mild_Hotspot 20.3%
F686Y A 686 0 0 0 NA Mild_Hotspot 13.8%
F68C A 68 0 0 0 NA Hotspot 78.8%
F68I A 68 0 0 0 NA Hotspot 72.5%
F68L A 68 5 5 0 NA Hotspot 81.7%
F68S A 68 0 0 0 NA Hotspot 78.8%
F68V A 68 2 1 1 NA Hotspot 70.6%
F68Y A 68 0 0 0 NA Hotspot 65.1%
F701C A 701 0 0 0 NA Mild_Hotspot 14.8%
F701I A 701 0 0 0 NA Mild_Hotspot 10.9%
F701L A 701 0 0 0 NA Mild_Hotspot 10.9%
F701S A 701 0 0 0 NA Mild_Hotspot 14.8%
F701V A 701 0 0 0 NA Mild_Hotspot 12.1%
F701Y A 701 0 0 0 NA Mild_Hotspot 8%
F720C A 720 0 0 0 NA Hotspot 46.7%
F720I A 720 0 0 0 NA Hotspot 41%
F720L A 720 0 0 0 NA Hotspot 41.1%
F720S A 720 0 0 0 NA Hotspot 46.6%
F720V A 720 0 0 0 NA Hotspot 43.8%
F720Y A 720 0 0 0 NA Hotspot 33%
F743C A 743 0 0 0 NA Mild_Hotspot 21.5%
F743I A 743 0 0 0 NA Mild_Hotspot 16.2%
F743L A 743 0 0 0 NA Mild_Hotspot 16.3%
F743S A 743 0 0 0 NA Mild_Hotspot 21.4%
F743V A 743 0 0 0 NA Mild_Hotspot 17.8%
F743Y A 743 0 0 0 NA Mild_Hotspot 12.1%
F758C A 758 0 0 0 NA Mild_Hotspot 28.1%
F758I A 758 0 0 0 NA Mild_Hotspot 21.7%
F758L A 758 0 0 0 NA Mild_Hotspot 21.8%
F758S A 758 0 0 0 NA Mild_Hotspot 28%
F758V A 758 0 0 0 NA Mild_Hotspot 23.7%
F758Y A 758 0 0 0 NA Mild_Hotspot 16.4%
F781C A 781 0 0 0 NA Hotspot 53.3%
F781I A 781 0 0 0 NA Hotspot 44.8%
F781L A 781 0 0 0 NA Hotspot 44.8%
F781S A 781 0 0 0 NA Hotspot 53.3%
F781V A 781 0 0 0 NA Hotspot 47.7%
F781Y A 781 0 0 0 NA Hotspot 36.5%
F805C A 805 9 7 2 LOF Hotspot 75.9%
F805I A 805 0 0 0 NA Hotspot 67.7%
F805L A 805 0 0 0 NA Hotspot 67.7%
F805S A 805 8 7 1 NA Hotspot 80.5%
F805V A 805 0 0 0 NA Hotspot 70.2%
F805Y A 805 0 0 0 NA Hotspot 59.8%
F848C A 848 0 0 0 NA Hotspot 45.2%
F848I A 848 0 0 0 NA Hotspot 36.9%
F848L A 848 0 0 0 NA Hotspot 36.9%
F848S A 848 0 0 0 NA Hotspot 45.1%
F848V A 848 0 0 0 NA Hotspot 39.6%
F848Y A 848 0 0 0 NA Hotspot 29.3%
F852C A 852 0 0 0 NA Hotspot 67.7%
F852I A 852 0 0 0 NA Hotspot 59.8%
F852L A 852 0 0 0 NA Hotspot 59.8%
F852S A 852 0 0 0 NA Hotspot 67.6%
F852V A 852 0 0 0 NA Hotspot 62.5%
F852Y A 852 0 0 0 NA Hotspot 51.3%
F860C A 860 0 0 0 NA Hotspot 60.3%
F860I A 860 0 0 0 NA Hotspot 51.8%
F860L A 860 0 0 0 NA Hotspot 51.9%
F860S A 860 0 0 0 NA Hotspot 60.3%
F860V A 860 0 0 0 NA Hotspot 54.7%
F860Y A 860 0 0 0 NA Hotspot 43.6%
F881C A 881 0 0 0 NA Non_Hotspot 9%
F881I A 881 1 0 1 NA Non_Hotspot 8.2%
F881L A 881 0 0 0 NA Non_Hotspot 8.2%
F881S A 881 0 0 0 NA Non_Hotspot 9.1%
F881V A 881 0 0 0 NA Non_Hotspot 9.1%
F881Y A 881 0 0 0 NA Non_Hotspot 6.7%
F891C A 891 0 0 0 NA Mild_Hotspot 17.2%
F891I A 891 0 0 0 NA Mild_Hotspot 14.2%
F891L A 891 0 0 0 NA Mild_Hotspot 12.9%
F891S A 891 0 0 0 NA Mild_Hotspot 17.3%
F891V A 891 0 0 0 NA Mild_Hotspot 15.7%
F891Y A 891 0 0 0 NA Mild_Hotspot 10.6%
F958C A 958 0 0 0 NA Non_Hotspot 8.1%
F958I A 958 0 0 0 NA Non_Hotspot 7.3%
F958L A 958 1 0 1 NA Non_Hotspot 6%
F958S A 958 0 0 0 NA Non_Hotspot 8.1%
F958V A 958 0 0 0 NA Non_Hotspot 7.3%
F958Y A 958 0 0 0 NA Non_Hotspot 5.9%
F98C A 98 0 0 0 NA Hotspot 70.5%
F98I A 98 0 0 0 NA Hotspot 65.4%
F98L A 98 0 0 0 NA Hotspot 60.3%
F98S A 98 0 0 0 NA Hotspot 70.2%
F98V A 98 0 0 0 NA Hotspot 67.9%
F98Y A 98 0 0 0 NA Hotspot 55%
F991C A 991 0 0 0 NA Non_Hotspot 7.3%
F991I A 991 0 0 0 NA Non_Hotspot 8.2%
F991L A 991 0 0 0 NA Non_Hotspot 8.2%
F991S A 991 0 0 0 NA Non_Hotspot 9.1%
F991V A 991 0 0 0 NA Non_Hotspot 9.1%
F991Y A 991 0 0 0 NA Non_Hotspot 7.4%
F998C A 998 0 0 0 NA Mild_Hotspot 22.6%
F998I A 998 0 0 0 NA Mild_Hotspot 19%
F998L A 998 0 0 0 NA Mild_Hotspot 19.2%
F998S A 998 0 0 0 NA Mild_Hotspot 20.6%
F998V A 998 0 0 0 NA Mild_Hotspot 20.8%
F998Y A 998 0 0 0 NA Mild_Hotspot 17.5%
G1002A A 1002 0 0 0 NA Non_Hotspot 8.3%
G1002E A 1002 1 0 1 NA Non_Hotspot 5.6%
G1002R A 1002 0 0 0 NA Non_Hotspot 7.4%
G1002V A 1002 0 0 0 NA Non_Hotspot 10.2%
G1002W A 1002 0 0 0 NA Non_Hotspot 10.1%
G1006A A 1006 0 0 0 NA Non_Hotspot 7.9%
G1006C A 1006 0 0 0 NA Non_Hotspot 9.7%
G1006D A 1006 0 0 0 NA Non_Hotspot 9.8%
G1006R A 1006 0 0 0 NA Non_Hotspot 8.8%
G1006S A 1006 0 0 0 NA Non_Hotspot 7.2%
G1006V A 1006 1 0 1 NA Non_Hotspot 8.8%
G1031A A 1031 0 0 0 NA Non_Hotspot 9.6%
G1031C A 1031 1 0 1 NA Non_Hotspot 7.4%
G1031D A 1031 0 0 0 NA Non_Hotspot 8.6%
G1031R A 1031 0 0 0 NA Non_Hotspot 11.7%
G1031S A 1031 0 0 0 NA Non_Hotspot 6.2%
G1031V A 1031 0 0 0 NA Non_Hotspot 11.7%
G1036A A 1036 0 0 0 NA Mild_Hotspot 21.7%
G1036C A 1036 0 0 0 NA Mild_Hotspot 23.9%
G1036D A 1036 21 3 18 LOF Mild_Hotspot 19.4%
G1036Del A 1036 1 1 0 NA Mild_Hotspot 33.6%
G1036R A 1036 0 0 0 NA Mild_Hotspot 30.5%
G1036S A 1036 0 0 0 NA Mild_Hotspot 18.1%
G1036V A 1036 0 0 0 NA Mild_Hotspot 30.5%
G103A A 103 0 0 0 NA Hotspot 73%
G103E A 103 0 0 0 NA Hotspot 77.2%
G103R A 103 0 0 0 NA Hotspot 77.6%
G103V A 103 0 0 0 NA Hotspot 77.2%
G103W A 103 0 0 0 NA Hotspot 77.5%
G1085A A 1085 0 0 0 NA Non_Hotspot 7.7%
G1085E A 1085 0 0 0 NA Non_Hotspot 8.6%
G1085R A 1085 0 0 0 NA Non_Hotspot 10.3%
G1085V A 1085 0 0 0 NA Non_Hotspot 10.6%
G1085W A 1085 0 0 0 NA Non_Hotspot 11.4%
G1087A A 1087 0 0 0 NA Non_Hotspot 6.9%
G1087C A 1087 0 0 0 NA Non_Hotspot 10.4%
G1087D A 1087 0 0 0 NA Non_Hotspot 9.5%
G1087R A 1087 0 0 0 NA Non_Hotspot 8.5%
G1087S A 1087 0 0 0 NA Non_Hotspot 7.6%
G1087V A 1087 0 0 0 NA Non_Hotspot 8.5%
G1123A A 1123 0 0 0 NA Non_Hotspot 7.3%
G1123E A 1123 0 0 0 NA Non_Hotspot 8.1%
G1123R A 1123 1 0 1 NA Non_Hotspot 6.8%
G1123V A 1123 0 0 0 NA Non_Hotspot 8.1%
G1123W A 1123 0 0 0 NA Non_Hotspot 9.9%
G1131A A 1131 0 0 0 NA Non_Hotspot 7.5%
G1131C A 1131 0 0 0 NA Non_Hotspot 10.2%
G1131D A 1131 0 0 0 NA Non_Hotspot 6.7%
G1131R A 1131 0 0 0 NA Non_Hotspot 9.2%
G1131S A 1131 0 0 0 NA Non_Hotspot 6.7%
G1131V A 1131 1 0 1 NA Non_Hotspot 9.2%
G1140A A 1140 0 0 0 NA Non_Hotspot 8.7%
G1140C A 1140 0 0 0 NA Non_Hotspot 10.6%
G1140D A 1140 0 0 0 NA Non_Hotspot 7%
G1140R A 1140 0 0 0 NA Non_Hotspot 9.6%
G1140S A 1140 0 0 0 NA Non_Hotspot 6.3%
G1140V A 1140 0 0 0 NA Non_Hotspot 9.5%
G1143A A 1143 0 0 0 NA Non_Hotspot 6.8%
G1143E A 1143 0 0 0 NA Non_Hotspot 9.3%
G1143R A 1143 0 0 0 NA Non_Hotspot 9.3%
G1143V A 1143 0 0 0 NA Non_Hotspot 8.3%
G1143W A 1143 0 0 0 NA Non_Hotspot 10.3%
G1154A A 1154 0 0 0 NA Mild_Hotspot 18.8%
G1154C A 1154 0 0 0 NA Mild_Hotspot 11.5%
G1154D A 1154 0 0 0 NA Mild_Hotspot 22.5%
G1154R A 1154 0 0 0 NA Mild_Hotspot 22.5%
G1154S A 1154 0 0 0 NA Mild_Hotspot 15.5%
G1154V A 1154 0 0 0 NA Mild_Hotspot 14.1%
G1158A A 1158 0 0 0 NA Non_Hotspot 10.3%
G1158C A 1158 0 0 0 NA Non_Hotspot 13.8%
G1158D A 1158 0 0 0 NA Non_Hotspot 11.2%
G1158R A 1158 0 0 0 NA Non_Hotspot 12.5%
G1158S A 1158 0 0 0 NA Non_Hotspot 10.3%
G1158V A 1158 0 0 0 NA Non_Hotspot 13.7%
G120A A 120 0 0 0 NA Non_Hotspot 9.5%
G120E A 120 0 0 0 NA Non_Hotspot 11.7%
G120R A 120 0 0 0 NA Non_Hotspot 11.6%
G120V A 120 0 0 0 NA Non_Hotspot 12.9%
G120W A 120 0 0 0 NA Non_Hotspot 11.6%
G139A A 139 3 0 3 NA Non_Hotspot 4.6%
G139E A 139 0 0 0 NA Non_Hotspot 7.4%
G139R A 139 2 0 2 NA Non_Hotspot 5.2%
G139V A 139 0 0 0 NA Non_Hotspot 9.1%
G139W A 139 0 0 0 NA Non_Hotspot 10%
G149A A 149 7 0 7 NA Non_Hotspot 4.3%
G149C A 149 0 0 0 NA Non_Hotspot 7.4%
G149D A 149 0 0 0 NA Non_Hotspot 8.2%
G149R A 149 0 0 0 NA Non_Hotspot 7.4%
G149S A 149 0 0 0 NA Non_Hotspot 7.4%
G149V A 149 2 0 2 NA Non_Hotspot 5.6%
G158A A 158 0 0 0 NA Non_Hotspot 9%
G158C A 158 0 0 0 NA Non_Hotspot 14.9%
G158D A 158 0 0 0 NA Non_Hotspot 13.6%
G158R A 158 0 0 0 NA Non_Hotspot 13.5%
G158S A 158 0 0 0 NA Non_Hotspot 11.1%
G158V A 158 0 0 0 NA Non_Hotspot 9.9%
G183A A 183 0 0 0 NA Hotspot 38.6%
G183C A 183 0 0 0 NA Hotspot 46.8%
G183D A 183 0 0 0 NA Hotspot 28.3%
G183R A 183 0 0 0 NA Hotspot 41.3%
G183S A 183 0 0 0 NA Hotspot 38.7%
G183V A 183 0 0 0 NA Hotspot 46.8%
G184A A 184 0 0 0 NA Hotspot 60.9%
G184C A 184 0 0 0 NA Hotspot 66.1%
G184D A 184 0 0 0 NA Hotspot 52.3%
G184Del A 184 1 1 0 NA Hotspot 66.2%
G184R A 184 0 0 0 NA Hotspot 63.7%
G184S A 184 0 0 0 NA Hotspot 61.1%
G184V A 184 0 0 0 NA Hotspot 63.6%
G186A A 186 0 0 0 NA Mild_Hotspot 13.3%
G186C A 186 0 0 0 NA Mild_Hotspot 16.2%
G186D A 186 0 0 0 NA Mild_Hotspot 11.9%
G186R A 186 0 0 0 NA Mild_Hotspot 13.3%
G186S A 186 0 0 0 NA Mild_Hotspot 13.3%
G186V A 186 0 0 0 NA Mild_Hotspot 14.7%
G187A A 187 1 0 1 NA Non_Hotspot 8.8%
G187C A 187 0 0 0 NA Non_Hotspot 11.9%
G187D A 187 0 0 0 NA Non_Hotspot 8.8%
G187Del A 187 6 1 5 NA Non_Hotspot 13.6%
G187R A 187 0 0 0 NA Non_Hotspot 9.7%
G187S A 187 1 0 1 Normal Non_Hotspot 8.9%
G187V A 187 0 0 0 NA Non_Hotspot 10.9%
G189A A 189 0 0 0 NA Non_Hotspot 8.8%
G189C A 189 0 0 0 NA Non_Hotspot 8.7%
G189D A 189 0 0 0 NA Non_Hotspot 8.8%
G189Ins A 189 2 0 2 NA Non_Hotspot 8.9%
G189R A 189 0 0 0 NA Non_Hotspot 9.7%
G189S A 189 0 0 0 NA Non_Hotspot 8.8%
G189V A 189 0 0 0 NA Non_Hotspot 9.7%
G192A A 192 0 0 0 NA Mild_Hotspot 19.4%
G192E A 192 0 0 0 NA Mild_Hotspot 21.1%
G192R A 192 0 0 0 NA Mild_Hotspot 21.1%
G192V A 192 0 0 0 NA Mild_Hotspot 23%
G192W A 192 0 0 0 NA Mild_Hotspot 25.1%
G224A A 224 0 0 0 NA Mild_Hotspot 11.2%
G224E A 224 0 0 0 NA Mild_Hotspot 12.4%
G224R A 224 0 0 0 NA Mild_Hotspot 13.5%
G224V A 224 0 0 0 NA Mild_Hotspot 12.2%
G224W A 224 0 0 0 NA Mild_Hotspot 14.9%
G226A A 226 0 0 0 NA Mild_Hotspot 12.9%
G226E A 226 0 0 0 NA Mild_Hotspot 15.7%
G226R A 226 0 0 0 NA Mild_Hotspot 11.6%
G226V A 226 0 0 0 NA Mild_Hotspot 15.6%
G226W A 226 0 0 0 NA Mild_Hotspot 10.4%
G236A A 236 0 0 0 NA Mild_Hotspot 15.3%
G236C A 236 0 0 0 NA Mild_Hotspot 16.7%
G236D A 236 0 0 0 NA Mild_Hotspot 18.4%
G236R A 236 0 0 0 NA Mild_Hotspot 18.5%
G236S A 236 0 0 0 NA Mild_Hotspot 16.8%
G236V A 236 5 0 5 NA Mild_Hotspot 13.4%
G238A A 238 0 0 0 NA Hotspot 49.8%
G238C A 238 0 0 0 NA Hotspot 55.5%
G238D A 238 2 0 2 NA Hotspot 41.2%
G238R A 238 1 1 0 NA Hotspot 57.8%
G238S A 238 1 1 0 NA Hotspot 49%
G238V A 238 0 0 0 NA Hotspot 55.4%
G246A A 246 0 0 0 NA Non_Hotspot 9%
G246C A 246 0 0 0 NA Non_Hotspot 6.5%
G246D A 246 0 0 0 NA Non_Hotspot 9.9%
G246R A 246 0 0 0 NA Non_Hotspot 9.9%
G246S A 246 0 0 0 NA Non_Hotspot 9%
G246T A 246 0 0 0 NA Non_Hotspot 11.2%
G246V A 246 0 0 0 NA Non_Hotspot 9%
G24A A 24 0 0 0 NA Hotspot 52.2%
G24C A 24 0 0 0 NA Hotspot 60.2%
G24D A 24 0 0 0 NA Hotspot 57.6%
G24R A 24 0 0 0 NA Hotspot 60.3%
G24S A 24 0 0 0 NA Hotspot 46.6%
G24V A 24 0 0 0 NA Hotspot 62.9%
G262A A 262 0 0 0 NA Non_Hotspot 7.3%
G262C A 262 0 0 0 NA Non_Hotspot 6.5%
G262D A 262 0 0 0 NA Non_Hotspot 8.1%
G262R A 262 0 0 0 NA Non_Hotspot 9%
G262S A 262 0 0 0 NA Non_Hotspot 8.1%
G262V A 262 0 0 0 NA Non_Hotspot 8.1%
G294A A 294 0 0 0 NA Non_Hotspot 8.7%
G294E A 294 0 0 0 NA Non_Hotspot 7.9%
G294R A 294 0 0 0 NA Non_Hotspot 9.7%
G294V A 294 0 0 0 Normal Non_Hotspot 10.6%
G294W A 294 0 0 0 NA Non_Hotspot 10.7%
G306A A 306 0 0 0 NA Hotspot 34.1%
G306E A 306 0 0 0 NA Hotspot 36.5%
G306R A 306 0 0 0 NA Hotspot 39.1%
G306V A 306 0 0 0 NA Hotspot 39.3%
G306W A 306 1 1 0 NA Hotspot 48.5%
G314A A 314 0 0 0 NA Non_Hotspot 8.4%
G314C A 314 0 0 0 NA Non_Hotspot 11.2%
G314D A 314 0 0 0 NA Non_Hotspot 9.1%
G314R A 314 0 0 0 NA Non_Hotspot 10.1%
G314S A 314 1 0 1 Normal Non_Hotspot 6.8%
G314V A 314 0 0 0 NA Non_Hotspot 10.2%
G345A A 345 0 0 0 NA Non_Hotspot 6.6%
G345C A 345 0 0 0 NA Non_Hotspot 9.1%
G345D A 345 0 0 0 NA Non_Hotspot 9.1%
G345R A 345 0 0 0 NA Non_Hotspot 9.1%
G345S A 345 2 0 2 NA Non_Hotspot 6.1%
G345V A 345 0 0 0 NA Non_Hotspot 9.1%
G381A A 381 0 0 0 NA Mild_Hotspot 22%
G381C A 381 0 0 0 NA Mild_Hotspot 28.4%
G381D A 381 0 0 0 NA Mild_Hotspot 26.1%
G381R A 381 0 0 0 NA Mild_Hotspot 28.5%
G381S A 381 0 0 0 NA Mild_Hotspot 22%
G381V A 381 0 0 0 NA Mild_Hotspot 28.4%
G439A A 439 0 0 0 NA Non_Hotspot 8.4%
G439C A 439 0 0 0 NA Non_Hotspot 10.4%
G439D A 439 0 0 0 NA Non_Hotspot 9.3%
G439R A 439 0 0 0 NA Non_Hotspot 9.4%
G439S A 439 0 0 0 NA Non_Hotspot 8.5%
G439V A 439 0 0 0 NA Non_Hotspot 10.4%
G446A A 446 0 0 0 NA Mild_Hotspot 29.6%
G446C A 446 0 0 0 NA Mild_Hotspot 34.4%
G446D A 446 0 0 0 NA Mild_Hotspot 31.8%
G446R A 446 0 0 0 NA Mild_Hotspot 34.4%
G446S A 446 0 0 0 NA Mild_Hotspot 27.3%
G446V A 446 0 0 0 NA Mild_Hotspot 34.4%
G47A A 47 0 0 0 NA Hotspot 68.6%
G47C A 47 1 1 0 NA Hotspot 79.8%
G47D A 47 0 0 0 NA Hotspot 75.1%
G47R A 47 0 0 0 NA Hotspot 77.4%
G47S A 47 0 0 0 NA Hotspot 73.1%
G47V A 47 8 8 0 NA Hotspot 88.4%
G487A A 487 0 0 0 NA Mild_Hotspot 9.3%
G487C A 487 0 0 0 NA Mild_Hotspot 13.8%
G487D A 487 0 0 0 NA Mild_Hotspot 13.8%
G487R A 487 3 0 3 Normal Mild_Hotspot 9.6%
G487S A 487 26 0 26 NA Mild_Hotspot 3.1%
G487V A 487 0 0 0 NA Mild_Hotspot 11.3%
G496A A 496 0 0 0 NA Hotspot 72.5%
G496C A 496 0 0 0 NA Hotspot 78.8%
G496D A 496 0 0 0 NA Hotspot 76.8%
G496R A 496 0 0 0 NA Hotspot 78.8%
G496S A 496 0 0 0 NA Hotspot 72.5%
G496V A 496 0 0 0 NA Hotspot 78.8%
G514A A 514 0 0 0 NA Non_Hotspot 8.1%
G514C A 514 0 0 0 NA Non_Hotspot 11%
G514D A 514 0 0 0 NA Non_Hotspot 8.9%
G514R A 514 0 0 0 NA Non_Hotspot 5.9%
G514S A 514 1 0 1 NA Non_Hotspot 8.1%
G514V A 514 0 0 0 NA Non_Hotspot 11%
G516A A 516 0 0 0 NA Mild_Hotspot 10.9%
G516C A 516 0 0 0 NA Mild_Hotspot 14.6%
G516D A 516 0 0 0 NA Mild_Hotspot 12.1%
G516R A 516 0 0 0 NA Mild_Hotspot 14.6%
G516S A 516 0 0 0 NA Mild_Hotspot 10.9%
G516V A 516 0 0 0 NA Mild_Hotspot 14.7%
G522A A 522 0 0 0 NA Non_Hotspot 9.6%
G522C A 522 0 0 0 NA Non_Hotspot 13.8%
G522E A 522 1 0 1 NA Non_Hotspot 10.6%
G522R A 522 0 0 0 NA Non_Hotspot 11.7%
G522V A 522 0 0 0 NA Non_Hotspot 12.9%
G522W A 522 0 0 0 NA Non_Hotspot 12.9%
G53A A 53 0 0 0 NA Hotspot 72.3%
G53C A 53 0 0 0 NA Hotspot 78.7%
G53D A 53 0 0 0 NA Hotspot 76.6%
G53R A 53 2 2 0 NA Hotspot 82.4%
G53S A 53 7 5 2 NA Hotspot 71.9%
G53V A 53 0 0 0 NA Hotspot 78.6%
G546A A 546 0 0 0 NA Non_Hotspot 9.5%
G546C A 546 0 0 0 NA Non_Hotspot 13.1%
G546D A 546 0 0 0 NA Non_Hotspot 10.5%
G546E A 546 0 0 0 NA Non_Hotspot 11.3%
G546I A 546 0 0 0 NA Non_Hotspot 15%
G546L A 546 0 0 0 NA Non_Hotspot 14.4%
G546Q A 546 0 0 0 NA Non_Hotspot 12.8%
G546R A 546 0 0 0 NA Non_Hotspot 12%
G546S A 546 0 0 0 NA Non_Hotspot 9.5%
G546V A 546 0 0 0 NA Non_Hotspot 12.9%
G546Y A 546 0 0 0 NA Non_Hotspot 16.9%
G572A A 572 0 0 0 NA Hotspot 77.8%
G572C A 572 4 4 0 NA Hotspot 88.2%
G572D A 572 3 2 1 NA Hotspot 78%
G572R A 572 4 4 0 Dominant LOF Hotspot 88.1%
G572S A 572 38 36 2 Severe Dominant LOF Hotspot 91.8%
G572V A 572 0 0 0 NA Hotspot 83.2%
G584A A 584 0 0 0 NA Hotspot 48.2%
G584C A 584 4 4 0 NA Hotspot 69.5%
G584D A 584 0 0 0 NA Hotspot 53.9%
G584R A 584 1 0 1 NA Hotspot 52%
G584S A 584 39 11 28 NA Hotspot 32.3%
G584V A 584 0 0 0 NA Hotspot 56.7%
G590A A 590 0 0 0 NA Hotspot 48.7%
G590C A 590 0 0 0 NA Hotspot 56.8%
G590D A 590 1 1 0 NA Hotspot 58.2%
G590R A 590 0 0 0 NA Hotspot 56.9%
G590S A 590 0 0 0 NA Hotspot 48.6%
G590V A 590 3 0 3 NA Hotspot 43.7%
G594A A 594 0 0 0 NA Hotspot 58.1%
G594C A 594 0 0 0 NA Hotspot 66.1%
G594D A 594 0 0 0 NA Hotspot 63.4%
G594R A 594 0 0 0 NA Hotspot 66.2%
G594S A 594 0 0 0 NA Hotspot 58.1%
G594V A 594 0 0 0 NA Hotspot 66%
G601A A 601 0 0 0 NA Hotspot 63.4%
G601C A 601 0 0 0 NA Hotspot 68.4%
G601D A 601 0 0 0 NA Hotspot 61%
G601R A 601 0 0 0 NA Hotspot 68.5%
G601S A 601 23 16 7 LOF Hotspot 66.8%
G601V A 601 0 0 0 NA Hotspot 63.4%
G603A A 603 0 0 0 NA Hotspot 72.7%
G603C A 603 0 0 0 NA Hotspot 77%
G603D A 603 5 3 2 NA Hotspot 69.7%
G603R A 603 0 0 0 NA Hotspot 77%
G603S A 603 0 0 0 NA Hotspot 68.2%
G603V A 603 0 0 0 NA Hotspot 78.9%
G604A A 604 0 0 0 NA Hotspot 79.9%
G604C A 604 2 2 0 NA Hotspot 87.6%
G604D A 604 1 1 0 NA Hotspot 84.8%
G604R A 604 0 0 0 NA Hotspot 84.9%
G604S A 604 40 36 4 Dominant LOF Hotspot 88%
G604V A 604 0 0 0 NA Hotspot 84.9%
G626A A 626 2 2 0 NA Hotspot 83.5%
G626C A 626 0 0 0 NA Hotspot 85.1%
G626D A 626 0 0 0 NA Hotspot 83.6%
G626R A 626 0 0 0 NA Hotspot 85.1%
G626S A 626 4 4 0 NA Hotspot 85.9%
G626V A 626 4 3 1 NA Hotspot 82.2%
G628A A 628 1 1 0 NA Hotspot 85%
G628C A 628 0 0 0 NA Hotspot 88%
G628D A 628 1 1 0 LOF Hotspot 85.3%
G628Del A 628 1 1 0 NA Hotspot 86%
G628R A 628 1 1 0 NA Hotspot 89.1%
G628S A 628 19 18 1 Severe Dominant LOF Hotspot 91.6%
G628V A 628 4 4 0 NA Hotspot 91.2%
G648A A 648 1 1 0 NA Hotspot 76.4%
G648C A 648 0 0 0 NA Hotspot 80.1%
G648D A 648 0 0 0 NA Hotspot 78.1%
G648I A 648 0 0 0 NA Hotspot 82.1%
G648L A 648 0 0 0 NA Hotspot 81.4%
G648P A 648 0 0 0 NA Hotspot 78.4%
G648R A 648 0 0 0 NA Hotspot 80.1%
G648S A 648 0 0 0 NA Hotspot 74%
G648V A 648 0 0 0 NA Hotspot 80%
G657A A 657 0 0 0 NA Hotspot 36.1%
G657C A 657 0 0 0 NA Hotspot 44.9%
G657D A 657 0 0 0 NA Hotspot 41.5%
G657I A 657 0 0 0 NA Hotspot 48.2%
G657R A 657 0 0 0 NA Hotspot 44.4%
G657S A 657 1 0 1 NA Hotspot 32.8%
G657V A 657 1 1 0 NA Hotspot 49.4%
G669A A 669 0 0 0 NA Non_Hotspot 9%
G669C A 669 1 0 1 NA Non_Hotspot 11.2%
G669D A 669 0 0 0 NA Non_Hotspot 11%
G669R A 669 1 0 1 NA Non_Hotspot 11.3%
G669S A 669 0 0 0 NA Non_Hotspot 9%
G669V A 669 0 0 0 NA Non_Hotspot 12.2%
G6A A 6 0 0 0 NA Mild_Hotspot 26.7%
G6C A 6 0 0 0 NA Mild_Hotspot 31.3%
G6D A 6 0 0 0 NA Mild_Hotspot 28.9%
G6R A 6 3 0 3 NA Mild_Hotspot 24.4%
G6S A 6 0 0 0 NA Mild_Hotspot 26.6%
G6V A 6 0 0 0 NA Mild_Hotspot 33.7%
G710A A 710 0 0 0 NA Mild_Hotspot 12.9%
G710C A 710 0 0 0 NA Mild_Hotspot 17.3%
G710D A 710 0 0 0 NA Mild_Hotspot 15.7%
G710R A 710 0 0 0 NA Mild_Hotspot 17.3%
G710S A 710 0 0 0 NA Mild_Hotspot 12.9%
G710V A 710 0 0 0 NA Mild_Hotspot 17.3%
G719A A 719 0 0 0 NA Hotspot 37.7%
G719C A 719 0 0 0 NA Hotspot 46.1%
G719D A 719 0 0 0 NA Hotspot 40.5%
G719R A 719 0 0 0 NA Hotspot 43.3%
G719S A 719 0 0 0 NA Hotspot 37.9%
G719V A 719 0 0 0 NA Hotspot 46.1%
G71A A 71 0 0 0 NA Hotspot 62.3%
G71E A 71 1 0 1 NA Hotspot 63.3%
G71R A 71 5 4 1 NA Hotspot 73.6%
G71V A 71 0 0 0 NA Hotspot 72.3%
G71W A 71 3 3 0 NA Hotspot 77.9%
G745A A 745 1 0 1 NA Non_Hotspot 9.2%
G745E A 745 0 0 0 NA Non_Hotspot 12.3%
G745R A 745 0 0 0 NA Non_Hotspot 13.6%
G745V A 745 0 0 0 NA Non_Hotspot 13.6%
G745W A 745 0 0 0 NA Non_Hotspot 13.6%
G749A A 749 0 0 0 NA Mild_Hotspot 24.7%
G749C A 749 0 0 0 NA Mild_Hotspot 31.5%
G749D A 749 0 0 0 NA Mild_Hotspot 29%
G749R A 749 0 0 0 NA Mild_Hotspot 31.4%
G749S A 749 0 0 0 NA Mild_Hotspot 24.6%
G749V A 749 0 0 0 NA Mild_Hotspot 31.4%
G766A A 766 0 0 0 NA Hotspot 44.5%
G766E A 766 0 0 0 NA Hotspot 50.2%
G766R A 766 0 0 0 NA Hotspot 53.1%
G766V A 766 0 0 0 NA Hotspot 53.1%
G766W A 766 0 0 0 NA Hotspot 53.1%
G773A A 773 0 0 0 NA Hotspot 52.5%
G773E A 773 0 0 0 NA Hotspot 58.2%
G773R A 773 0 0 0 NA Hotspot 61%
G773V A 773 0 0 0 NA Hotspot 60.9%
G773W A 773 0 0 0 NA Hotspot 60.9%
G785A A 785 0 0 0 NA Hotspot 44.6%
G785C A 785 0 0 0 NA Hotspot 53.2%
G785D A 785 4 3 1 Dominant LOF Hotspot 57.2%
G785R A 785 0 0 0 NA Hotspot 53.3%
G785S A 785 2 1 1 NA Hotspot 45.6%
G785V A 785 0 0 0 NA Hotspot 53.2%
G792A A 792 0 0 0 NA Mild_Hotspot 10.8%
G792C A 792 0 0 0 NA Mild_Hotspot 14.5%
G792D A 792 0 0 0 NA Mild_Hotspot 9.8%
G792R A 792 0 0 0 NA Mild_Hotspot 13.2%
G792S A 792 0 0 0 NA Mild_Hotspot 10.8%
G792V A 792 0 0 0 NA Mild_Hotspot 14.6%
G800A A 800 0 0 0 NA Hotspot 56.5%
G800E A 800 0 0 0 NA Hotspot 62%
G800R A 800 0 0 0 NA Hotspot 64.7%
G800V A 800 0 0 0 NA Hotspot 64.7%
G800W A 800 0 0 0 NA Hotspot 64.6%
G806A A 806 0 0 0 NA Hotspot 72.2%
G806D A 806 0 0 0 NA Hotspot 71.1%
G806E A 806 0 0 0 NA Hotspot 75.7%
G806R A 806 3 3 0 NA Hotspot 83.7%
G806V A 806 0 0 0 NA Hotspot 78.5%
G806W A 806 0 0 0 NA Hotspot 77.7%
G816A A 816 0 0 0 NA Mild_Hotspot 18.3%
G816C A 816 0 0 0 NA Mild_Hotspot 24%
G816D A 816 0 0 0 NA Mild_Hotspot 21.9%
G816R A 816 0 0 0 NA Mild_Hotspot 24%
G816S A 816 0 0 0 NA Mild_Hotspot 18.3%
G816V A 816 3 0 3 Normal Mild_Hotspot 16%
G820A A 820 0 0 0 NA Mild_Hotspot 18.2%
G820E A 820 0 0 0 NA Mild_Hotspot 27.9%
G820R A 820 4 1 3 NA Mild_Hotspot 29.1%
G820V A 820 0 0 0 NA Mild_Hotspot 28.1%
G820W A 820 0 0 0 NA Mild_Hotspot 32.7%
G870A A 870 0 0 0 NA Non_Hotspot 8.4%
G870C A 870 0 0 0 NA Non_Hotspot 11.4%
G870D A 870 0 0 0 NA Non_Hotspot 9.3%
G870R A 870 0 0 0 NA Non_Hotspot 6.8%
G870S A 870 0 0 0 NA Non_Hotspot 8.5%
G870V A 870 0 0 0 NA Non_Hotspot 11.4%
G873A A 873 0 0 0 NA Non_Hotspot 7.5%
G873C A 873 1 0 1 NA Non_Hotspot 8.5%
G873D A 873 0 0 0 NA Non_Hotspot 7.4%
G873R A 873 0 0 0 NA Non_Hotspot 8.2%
G873S A 873 75 0 75 GOF Non_Hotspot 0.6%
G873V A 873 0 0 0 NA Non_Hotspot 9.2%
G879A A 879 0 0 0 NA Non_Hotspot 9.6%
G879C A 879 0 0 0 NA Non_Hotspot 6.9%
G879D A 879 0 0 0 NA Non_Hotspot 10.6%
G879R A 879 0 0 0 NA Non_Hotspot 11.6%
G879S A 879 0 0 0 NA Non_Hotspot 8.6%
G879V A 879 0 0 0 NA Non_Hotspot 11.6%
G880A A 880 0 0 0 NA Mild_Hotspot 12%
G880C A 880 0 0 0 NA Mild_Hotspot 13.2%
G880D A 880 0 0 0 NA Mild_Hotspot 9.8%
G880R A 880 0 0 0 NA Mild_Hotspot 14.6%
G880S A 880 0 0 0 NA Mild_Hotspot 12%
G880V A 880 4 1 3 NA Mild_Hotspot 17.6%
G88A A 88 0 0 0 NA Mild_Hotspot 28.4%
G88C A 88 0 0 0 NA Mild_Hotspot 35.6%
G88D A 88 0 0 0 NA Mild_Hotspot 33.1%
G88R A 88 0 0 0 NA Mild_Hotspot 35.7%
G88S A 88 0 0 0 NA Mild_Hotspot 30.7%
G88V A 88 0 0 0 NA Mild_Hotspot 38.3%
G903A A 903 0 0 0 NA Non_Hotspot 7.3%
G903E A 903 0 0 0 NA Non_Hotspot 8.2%
G903R A 903 21 0 21 NA Non_Hotspot 2.7%
G903V A 903 0 0 0 NA Non_Hotspot 10%
G903W A 903 0 0 0 NA Non_Hotspot 9%
G909A A 909 0 0 0 NA Non_Hotspot 8.4%
G909E A 909 0 0 0 NA Non_Hotspot 8.4%
G909R A 909 0 0 0 NA Non_Hotspot 7.6%
G909V A 909 0 0 0 NA Non_Hotspot 10.4%
G909W A 909 0 0 0 NA Non_Hotspot 10.3%
G911A A 911 0 0 0 NA Non_Hotspot 9.6%
G911C A 911 0 0 0 NA Non_Hotspot 11.7%
G911D A 911 0 0 0 NA Non_Hotspot 9.5%
G911R A 911 0 0 0 NA Non_Hotspot 9.5%
G911S A 911 0 0 0 NA Non_Hotspot 8.7%
G911V A 911 0 0 0 NA Non_Hotspot 10.5%
G914A A 914 0 0 0 NA Non_Hotspot 8.6%
G914E A 914 0 0 0 NA Non_Hotspot 10.5%
G914R A 914 0 0 0 NA Non_Hotspot 10.6%
G914V A 914 0 0 0 NA Non_Hotspot 10.5%
G914W A 914 0 0 0 NA Non_Hotspot 12.9%
G916A A 916 0 0 0 NA Non_Hotspot 9%
G916E A 916 0 0 0 NA Non_Hotspot 9.8%
G916R A 916 0 0 0 NA Non_Hotspot 9.8%
G916V A 916 0 0 0 NA Non_Hotspot 12.1%
G916W A 916 0 0 0 NA Non_Hotspot 13.2%
G921A A 921 0 0 0 NA Mild_Hotspot 13%
G921C A 921 0 0 0 NA Mild_Hotspot 14.4%
G921D A 921 0 0 0 NA Mild_Hotspot 11.7%
G921R A 921 0 0 0 NA Mild_Hotspot 14.2%
G921S A 921 0 0 0 NA Mild_Hotspot 12.9%
G921V A 921 0 0 0 NA Mild_Hotspot 14.3%
G924A A 924 8 0 8 NA Mild_Hotspot 7.4%
G924E A 924 10 0 10 NA Mild_Hotspot 6.7%
G924R A 924 0 0 0 NA Mild_Hotspot 13.4%
G924V A 924 1 0 1 NA Mild_Hotspot 14.7%
G924W A 924 3 1 2 NA Mild_Hotspot 20.9%
G925A A 925 1 0 1 NA Mild_Hotspot 19.3%
G925E A 925 4 0 4 NA Mild_Hotspot 16.6%
G925R A 925 1 1 0 NA Mild_Hotspot 30.6%
G925V A 925 3 0 3 NA Mild_Hotspot 20.9%
G925W A 925 0 0 0 NA Mild_Hotspot 27.2%
G928A A 928 0 0 0 NA Non_Hotspot 10.5%
G928E A 928 1 0 1 NA Non_Hotspot 7.1%
G928R A 928 0 0 0 NA Non_Hotspot 11.5%
G928V A 928 0 0 0 NA Non_Hotspot 12.7%
G928W A 928 0 0 0 NA Non_Hotspot 11.5%
G934A A 934 0 0 0 NA Non_Hotspot 10.2%
G934C A 934 0 0 0 NA Non_Hotspot 10.2%
G934D A 934 0 0 0 NA Non_Hotspot 11.3%
G934R A 934 0 0 0 NA Non_Hotspot 12.5%
G934S A 934 0 0 0 NA Non_Hotspot 8.3%
G934V A 934 0 0 0 NA Non_Hotspot 10.2%
G945A A 945 0 0 0 NA Mild_Hotspot 16.6%
G945C A 945 0 0 0 NA Mild_Hotspot 19.9%
G945D A 945 0 0 0 NA Mild_Hotspot 16.5%
G945R A 945 0 0 0 NA Mild_Hotspot 18.2%
G945S A 945 0 0 0 NA Mild_Hotspot 16.6%
G945V A 945 0 0 0 NA Mild_Hotspot 19.9%
G947A A 947 0 0 0 NA Mild_Hotspot 10.5%
G947C A 947 0 0 0 NA Mild_Hotspot 14.1%
G947D A 947 1 0 1 NA Mild_Hotspot 11.6%
G947R A 947 0 0 0 NA Mild_Hotspot 12.8%
G947S A 947 0 0 0 NA Mild_Hotspot 11.5%
G947V A 947 0 0 0 NA Mild_Hotspot 11.5%
G965A A 965 0 0 0 NA Non_Hotspot 6.7%
G965E A 965 0 0 0 NA Non_Hotspot 7.3%
G965R A 965 4 0 4 NA Non_Hotspot 6%
G965V A 965 0 0 0 NA Non_Hotspot 9.1%
G969A A 969 0 0 0 NA Non_Hotspot 6.8%
G969C A 969 0 0 0 NA Non_Hotspot 10.2%
G969D A 969 1 0 1 NA Non_Hotspot 6.7%
G969R A 969 0 0 0 NA Non_Hotspot 8.2%
G969S A 969 0 0 0 NA Non_Hotspot 6.8%
G969V A 969 0 0 0 NA Non_Hotspot 9.1%
G970A A 970 1 0 1 NA Non_Hotspot 6.8%
G970E A 970 0 0 0 NA Non_Hotspot 7.4%
G970R A 970 0 0 0 NA Non_Hotspot 8.3%
G970V A 970 0 0 0 NA Non_Hotspot 8.3%
G970W A 970 0 0 0 NA Non_Hotspot 10.2%
G989A A 989 0 0 0 NA Non_Hotspot 6.6%
G989C A 989 0 0 0 NA Non_Hotspot 9%
G989D A 989 1 0 1 NA Non_Hotspot 5.5%
G989R A 989 0 0 0 NA Non_Hotspot 5.9%
G989S A 989 1 0 1 NA Non_Hotspot 6.6%
G989V A 989 0 0 0 NA Non_Hotspot 9%
G993A A 993 0 0 0 NA Mild_Hotspot 15.1%
G993E A 993 0 0 0 NA Mild_Hotspot 15.1%
G993R A 993 0 0 0 NA Mild_Hotspot 16.6%
G993V A 993 0 0 0 NA Mild_Hotspot 16.6%
H1151D A 1151 0 0 0 NA Non_Hotspot 10.4%
H1151L A 1151 0 0 0 NA Non_Hotspot 12.7%
H1151N A 1151 0 0 0 NA Non_Hotspot 9.5%
H1151P A 1151 0 0 0 NA Non_Hotspot 11.5%
H1151Q A 1151 2 0 2 NA Non_Hotspot 4.6%
H1151R A 1151 0 0 0 NA Non_Hotspot 9.4%
H1151Y A 1151 0 0 0 NA Non_Hotspot 8.5%
H1153D A 1153 0 0 0 NA Mild_Hotspot 35%
H1153L A 1153 0 0 0 NA Mild_Hotspot 40.5%
H1153N A 1153 0 0 0 NA Mild_Hotspot 30.2%
H1153P A 1153 1 1 0 NA Mild_Hotspot 43.1%
H1153Q A 1153 0 0 0 NA Mild_Hotspot 30.4%
H1153R A 1153 0 0 0 NA Mild_Hotspot 32.6%
H1153Y A 1153 10 0 10 NA Mild_Hotspot 13.8%
H143D A 143 0 0 0 NA Non_Hotspot 8.3%
H143L A 143 0 0 0 NA Non_Hotspot 9.2%
H143N A 143 0 0 0 NA Non_Hotspot 8.3%
H143P A 143 0 0 0 NA Non_Hotspot 7.4%
H143Q A 143 0 0 0 NA Non_Hotspot 5.4%
H143R A 143 0 0 0 NA Non_Hotspot 5.4%
H143Y A 143 0 0 0 NA Non_Hotspot 9.2%
H147D A 147 0 0 0 NA Non_Hotspot 9%
H147L A 147 0 0 0 NA Non_Hotspot 11.1%
H147N A 147 0 0 0 NA Non_Hotspot 6.6%
H147P A 147 0 0 0 NA Non_Hotspot 9.9%
H147Q A 147 0 0 0 NA Non_Hotspot 8.1%
H147R A 147 16 0 16 NA Non_Hotspot 3.4%
H147Y A 147 0 0 0 NA Non_Hotspot 8.1%
H221D A 221 0 0 0 NA Mild_Hotspot 12.1%
H221L A 221 0 0 0 NA Mild_Hotspot 13.4%
H221N A 221 0 0 0 NA Mild_Hotspot 11%
H221P A 221 0 0 0 NA Mild_Hotspot 10.9%
H221Q A 221 0 0 0 NA Mild_Hotspot 9.7%
H221R A 221 0 0 0 NA Mild_Hotspot 9%
H221Y A 221 0 0 0 NA Mild_Hotspot 12.1%
H254D A 254 0 0 0 NA Non_Hotspot 5.9%
H254L A 254 0 0 0 NA Non_Hotspot 9.1%
H254N A 254 0 0 0 NA Non_Hotspot 7.4%
H254P A 254 0 0 0 NA Non_Hotspot 8.1%
H254Q A 254 1 0 1 Normal Non_Hotspot 5.7%
H254R A 254 0 0 0 NA Non_Hotspot 8.2%
H254Y A 254 0 0 0 NA Non_Hotspot 8.2%
H302D A 302 0 0 0 NA Non_Hotspot 11.7%
H302L A 302 0 0 0 NA Non_Hotspot 13%
H302N A 302 0 0 0 NA Non_Hotspot 10.6%
H302P A 302 0 0 0 NA Non_Hotspot 7.8%
H302Q A 302 0 0 0 NA Non_Hotspot 10.6%
H302R A 302 0 0 0 NA Non_Hotspot 9.6%
H302Y A 302 0 0 0 NA Non_Hotspot 10.6%
H309D A 309 0 0 0 NA Non_Hotspot 8.1%
H309L A 309 0 0 0 NA Non_Hotspot 11.1%
H309N A 309 0 0 0 NA Non_Hotspot 4.8%
H309P A 309 0 0 0 NA Non_Hotspot 10%
H309Q A 309 1 0 1 NA Non_Hotspot 7.2%
H309R A 309 0 0 0 NA Non_Hotspot 7.3%
H309Y A 309 2 0 2 NA Non_Hotspot 7.5%
H368D A 368 0 0 0 NA Non_Hotspot 10.2%
H368L A 368 0 0 0 NA Non_Hotspot 9.1%
H368N A 368 0 0 0 NA Non_Hotspot 8.3%
H368P A 368 0 0 0 NA Non_Hotspot 10.2%
H368Q A 368 0 0 0 NA Non_Hotspot 8.4%
H368R A 368 0 0 0 NA Non_Hotspot 9.2%
H368Y A 368 1 0 1 NA Non_Hotspot 6.8%
H396D A 396 0 0 0 NA Non_Hotspot 10.7%
H396L A 396 0 0 0 NA Non_Hotspot 13%
H396N A 396 0 0 0 NA Non_Hotspot 7.9%
H396P A 396 0 0 0 NA Non_Hotspot 11.8%
H396Q A 396 0 0 0 NA Non_Hotspot 9.7%
H396R A 396 0 0 0 NA Non_Hotspot 9.6%
H396Y A 396 0 0 0 NA Non_Hotspot 8.6%
H402D A 402 0 0 0 NA Hotspot 78.3%
H402L A 402 0 0 0 NA Hotspot 82%
H402N A 402 0 0 0 NA Hotspot 76.3%
H402P A 402 0 0 0 NA Hotspot 80.2%
H402Q A 402 0 0 0 NA Hotspot 76.4%
H402R A 402 8 8 0 NA Hotspot 86.8%
H402Y A 402 0 0 0 NA Hotspot 71.9%
H485D A 485 0 0 0 NA Mild_Hotspot 14.8%
H485L A 485 0 0 0 NA Mild_Hotspot 23.5%
H485N A 485 0 0 0 NA Mild_Hotspot 16.5%
H485P A 485 0 0 0 NA Mild_Hotspot 21.5%
H485Q A 485 0 0 0 NA Mild_Hotspot 15.6%
H485R A 485 0 0 0 NA Mild_Hotspot 17.9%
H485Y A 485 0 0 0 NA Mild_Hotspot 16.2%
H492D A 492 0 0 0 NA Hotspot 55.3%
H492L A 492 0 0 0 NA Hotspot 60.8%
H492N A 492 0 0 0 NA Hotspot 52.7%
H492P A 492 0 0 0 NA Hotspot 60.8%
H492Q A 492 0 0 0 NA Hotspot 52.5%
H492R A 492 0 0 0 NA Hotspot 52.5%
H492Y A 492 41 19 22 LOF Hotspot 46.3%
H562A A 562 0 0 0 NA Hotspot 59.2%
H562D A 562 0 0 0 NA Hotspot 53.7%
H562L A 562 0 0 0 NA Hotspot 59.3%
H562N A 562 0 0 0 NA Hotspot 50.9%
H562P A 562 4 3 1 Severe Dominant LOF Hotspot 67.2%
H562Q A 562 2 0 2 NA Hotspot 42.4%
H562R A 562 21 16 5 NA Hotspot 68%
H562Y A 562 0 0 0 NA Hotspot 45.1%
H578A A 578 0 0 0 NA Mild_Hotspot 31.3%
H578D A 578 0 0 0 NA Mild_Hotspot 27.7%
H578L A 578 0 0 0 NA Mild_Hotspot 27.7%
H578N A 578 0 0 0 NA Mild_Hotspot 25.6%
H578P A 578 0 0 0 NA Mild_Hotspot 27.5%
H578Q A 578 0 0 0 NA Mild_Hotspot 25.5%
H578R A 578 0 0 0 NA Mild_Hotspot 27.6%
H578Y A 578 0 0 0 NA Mild_Hotspot 17.7%
H587A A 587 0 0 0 NA Hotspot 64.2%
H587D A 587 0 0 0 NA Hotspot 49.4%
H587K A 587 0 0 0 NA Hotspot 63.2%
H587L A 587 0 0 0 NA Hotspot 65.6%
H587N A 587 0 0 0 NA Hotspot 55%
H587P A 587 0 0 0 NA Hotspot 62.8%
H587Q A 587 0 0 0 NA Hotspot 57.2%
H587R A 587 0 0 0 NA Hotspot 57.4%
H587Y A 587 0 0 0 NA Hotspot 52%
H674D A 674 0 0 0 NA Non_Hotspot 11.1%
H674L A 674 0 0 0 NA Non_Hotspot 13.6%
H674N A 674 0 0 0 NA Non_Hotspot 10%
H674P A 674 0 0 0 NA Non_Hotspot 13.6%
H674Q A 674 0 0 0 NA Non_Hotspot 10.1%
H674R A 674 0 0 0 NA Non_Hotspot 10%
H674Y A 674 1 0 1 NA Non_Hotspot 7.5%
H687D A 687 0 0 0 NA Mild_Hotspot 31.1%
H687L A 687 0 0 0 NA Mild_Hotspot 36.3%
H687N A 687 0 0 0 NA Mild_Hotspot 28.8%
H687P A 687 0 0 0 NA Mild_Hotspot 36.2%
H687Q A 687 0 0 0 NA Mild_Hotspot 28.9%
H687R A 687 0 0 0 NA Mild_Hotspot 28.7%
H687Y A 687 0 0 0 NA Mild_Hotspot 24.2%
H703D A 703 0 0 0 NA Mild_Hotspot 15.7%
H703L A 703 0 0 0 NA Mild_Hotspot 19.1%
H703N A 703 0 0 0 NA Mild_Hotspot 14.3%
H703P A 703 0 0 0 NA Mild_Hotspot 19%
H703Q A 703 0 0 0 NA Mild_Hotspot 14.5%
H703R A 703 0 0 0 NA Mild_Hotspot 14.3%
H703Y A 703 0 0 0 NA Mild_Hotspot 11.7%
H70D A 70 0 0 0 NA Hotspot 67.5%
H70L A 70 0 0 0 NA Hotspot 67.5%
H70N A 70 0 0 0 NA Hotspot 65%
H70P A 70 0 0 0 NA Hotspot 69.8%
H70Q A 70 3 1 2 NA Hotspot 57.7%
H70R A 70 3 3 0 NA Hotspot 72.6%
H70Y A 70 0 0 0 NA Hotspot 45.6%
H731D A 731 0 0 0 NA Hotspot 68.8%
H731L A 731 0 0 0 NA Hotspot 73.4%
H731N A 731 0 0 0 NA Hotspot 66.3%
H731P A 731 0 0 0 NA Hotspot 71%
H731Q A 731 0 0 0 NA Hotspot 66.4%
H731R A 731 1 1 0 NA Hotspot 69.2%
H731Y A 731 0 0 0 NA Hotspot 63.5%
H739D A 739 0 0 0 NA Mild_Hotspot 11.4%
H739L A 739 0 0 0 NA Mild_Hotspot 16.8%
H739N A 739 0 0 0 NA Mild_Hotspot 7.5%
H739P A 739 0 0 0 NA Mild_Hotspot 15.2%
H739Q A 739 0 0 0 NA Mild_Hotspot 12.5%
H739R A 739 0 0 0 NA Mild_Hotspot 13.9%
H739Y A 739 0 0 0 NA Mild_Hotspot 12.5%
H762D A 762 0 0 0 NA Mild_Hotspot 13.4%
H762L A 762 0 0 0 NA Mild_Hotspot 16.3%
H762N A 762 0 0 0 NA Mild_Hotspot 12.2%
H762P A 762 0 0 0 NA Mild_Hotspot 16.2%
H762Q A 762 0 0 0 NA Mild_Hotspot 12.3%
H762R A 762 0 0 0 NA Mild_Hotspot 12.1%
H762Y A 762 0 0 0 NA Mild_Hotspot 9.9%
H771D A 771 0 0 0 NA Hotspot 63.2%
H771L A 771 0 0 0 NA Hotspot 68.3%
H771N A 771 0 0 0 NA Hotspot 60.7%
H771P A 771 0 0 0 NA Hotspot 68.2%
H771Q A 771 0 0 0 NA Hotspot 60.8%
H771R A 771 2 2 0 NA Hotspot 67%
H771Y A 771 0 0 0 NA Hotspot 54.9%
H7D A 7 0 0 0 NA Mild_Hotspot 18.8%
H7L A 7 0 0 0 NA Mild_Hotspot 23%
H7N A 7 0 0 0 NA Mild_Hotspot 15.7%
H7P A 7 0 0 0 NA Mild_Hotspot 20.6%
H7Q A 7 0 0 0 NA Mild_Hotspot 17.3%
H7R A 7 0 0 0 NA Mild_Hotspot 17.4%
H7Y A 7 0 0 0 NA Mild_Hotspot 14.2%
H831D A 831 0 0 0 NA Mild_Hotspot 27.5%
H831L A 831 0 0 0 NA Mild_Hotspot 32.5%
H831N A 831 0 0 0 NA Mild_Hotspot 25.4%
H831P A 831 0 0 0 NA Mild_Hotspot 32.3%
H831Q A 831 0 0 0 NA Mild_Hotspot 25.4%
H831R A 831 0 0 0 NA Mild_Hotspot 25.2%
H831Y A 831 0 0 0 NA Mild_Hotspot 21.2%
H834D A 834 0 0 0 NA Mild_Hotspot 21.6%
H834L A 834 0 0 0 NA Mild_Hotspot 21.7%
H834N A 834 0 0 0 NA Mild_Hotspot 19.9%
H834P A 834 0 0 0 NA Mild_Hotspot 23.6%
H834Q A 834 0 0 0 NA Mild_Hotspot 14.9%
H834R A 834 1 0 1 NA Mild_Hotspot 17.9%
H834Y A 834 0 0 0 NA Mild_Hotspot 18%
H851D A 851 0 0 0 NA Hotspot 51.1%
H851L A 851 0 0 0 NA Hotspot 51.1%
H851N A 851 0 0 0 NA Hotspot 42.6%
H851P A 851 0 0 0 NA Hotspot 53.9%
H851Q A 851 0 0 0 NA Hotspot 45.3%
H851R A 851 0 0 0 NA Hotspot 45.2%
H851Y A 851 0 0 0 NA Hotspot 37.2%
I1025F A 1025 0 0 0 NA Non_Hotspot 9.4%
I1025L A 1025 0 0 0 NA Non_Hotspot 8.5%
I1025M A 1025 0 0 0 NA Non_Hotspot 8.5%
I1025N A 1025 0 0 0 NA Non_Hotspot 7.6%
I1025S A 1025 0 0 0 NA Non_Hotspot 8.4%
I1025T A 1025 0 0 0 NA Non_Hotspot 6.1%
I1025V A 1025 0 0 0 NA Non_Hotspot 6.9%
I123F A 123 0 0 0 NA Hotspot 35.3%
I123L A 123 0 0 0 NA Hotspot 44.2%
I123M A 123 0 0 0 NA Hotspot 30.8%
I123N A 123 0 0 0 NA Hotspot 57.8%
I123S A 123 0 0 0 NA Hotspot 55%
I123T A 123 0 0 0 NA Hotspot 49.4%
I123V A 123 0 0 0 NA Hotspot 41.6%
I126F A 126 0 0 0 NA Hotspot 62.6%
I126L A 126 0 0 0 NA Hotspot 54.7%
I126M A 126 0 0 0 NA Hotspot 59.8%
I126N A 126 0 0 0 NA Hotspot 72.5%
I126S A 126 0 0 0 NA Hotspot 70.1%
I126T A 126 0 0 0 NA Hotspot 65.1%
I126V A 126 0 0 0 NA Hotspot 54.7%
I18F A 18 0 0 0 NA Mild_Hotspot 25.7%
I18L A 18 0 0 0 NA Mild_Hotspot 21.8%
I18M A 18 1 0 1 NA Mild_Hotspot 21.1%
I18N A 18 0 0 0 NA Mild_Hotspot 32.6%
I18S A 18 0 0 0 NA Mild_Hotspot 30.1%
I18T A 18 0 0 0 NA Mild_Hotspot 27.8%
I18V A 18 0 0 0 NA Mild_Hotspot 19.9%
I19F A 19 1 1 0 NA Hotspot 70.5%
I19L A 19 0 0 0 NA Hotspot 62.9%
I19M A 19 0 0 0 NA Hotspot 65.4%
I19N A 19 0 0 0 NA Hotspot 74.7%
I19S A 19 0 0 0 NA Hotspot 72.5%
I19T A 19 0 0 0 NA Hotspot 70.1%
I19V A 19 0 0 0 NA Hotspot 60.3%
I288F A 288 0 0 0 NA Non_Hotspot 7.3%
I288L A 288 0 0 0 NA Non_Hotspot 9.1%
I288M A 288 0 0 0 NA Non_Hotspot 9.1%
I288N A 288 0 0 0 NA Non_Hotspot 12.2%
I288S A 288 0 0 0 NA Non_Hotspot 12.2%
I288T A 288 0 0 0 NA Non_Hotspot 12.2%
I288V A 288 0 0 0 NA Non_Hotspot 9%
I30Del A 30 1 1 0 NA Hotspot 81%
I30F A 30 0 0 0 NA Hotspot 79.8%
I30L A 30 0 0 0 NA Hotspot 74%
I30M A 30 0 0 0 NA Hotspot 75.8%
I30N A 30 0 0 0 NA Hotspot 84.6%
I30S A 30 0 0 0 NA Hotspot 83.1%
I30T A 30 1 1 0 NA Hotspot 81.4%
I30V A 30 0 0 0 NA Hotspot 71.8%
I31F A 31 0 0 0 NA Hotspot 76%
I31L A 31 0 0 0 NA Hotspot 72.1%
I31M A 31 0 0 0 NA Hotspot 74%
I31N A 31 0 0 0 NA Hotspot 81.7%
I31S A 31 1 1 0 Dominant LOF Hotspot 82.1%
I31T A 31 0 0 0 NA Hotspot 78%
I31V A 31 0 0 0 NA Hotspot 69.9%
I330F A 330 0 0 0 NA Non_Hotspot 7.3%
I330L A 330 0 0 0 NA Non_Hotspot 6.6%
I330M A 330 0 0 0 NA Non_Hotspot 7.4%
I330N A 330 0 0 0 NA Non_Hotspot 11.1%
I330S A 330 0 0 0 NA Non_Hotspot 9.1%
I330T A 330 0 0 0 NA Non_Hotspot 9%
I330V A 330 1 0 1 NA Non_Hotspot 6%
I333F A 333 0 0 0 NA Mild_Hotspot 20.8%
I333L A 333 0 0 0 NA Mild_Hotspot 17.4%
I333M A 333 0 0 0 NA Mild_Hotspot 19.1%
I333N A 333 0 0 0 NA Mild_Hotspot 24.8%
I333S A 333 0 0 0 NA Mild_Hotspot 22.6%
I333T A 333 0 0 0 NA Mild_Hotspot 20.7%
I333V A 333 0 0 0 NA Mild_Hotspot 14.5%
I336F A 336 0 0 0 NA Mild_Hotspot 10.5%
I336L A 336 0 0 0 NA Mild_Hotspot 9.4%
I336M A 336 0 0 0 NA Mild_Hotspot 10.3%
I336N A 336 0 0 0 NA Mild_Hotspot 15.2%
I336S A 336 0 0 0 NA Mild_Hotspot 13.8%
I336T A 336 0 0 0 NA Mild_Hotspot 11.3%
I336V A 336 0 0 0 NA Mild_Hotspot 9.5%
I358F A 358 0 0 0 NA Non_Hotspot 8.7%
I358L A 358 0 0 0 NA Non_Hotspot 7.1%
I358M A 358 0 0 0 NA Non_Hotspot 7.8%
I358N A 358 0 0 0 NA Non_Hotspot 11.7%
I358S A 358 0 0 0 NA Non_Hotspot 9.5%
I358T A 358 0 0 0 NA Non_Hotspot 8.6%
I358V A 358 0 0 0 NA Non_Hotspot 6.3%
I359K A 359 0 0 0 NA Non_Hotspot 8.4%
I359L A 359 0 0 0 NA Non_Hotspot 7%
I359M A 359 0 0 0 NA Non_Hotspot 7.7%
I359R A 359 0 0 0 NA Non_Hotspot 6.1%
I359T A 359 0 0 0 NA Non_Hotspot 8.4%
I359V A 359 1 0 1 NA Non_Hotspot 5.6%
I363K A 363 0 0 0 NA Mild_Hotspot 27.1%
I363L A 363 0 0 0 NA Mild_Hotspot 16.1%
I363M A 363 0 0 0 NA Mild_Hotspot 19.1%
I363R A 363 0 0 0 NA Mild_Hotspot 27.1%
I363T A 363 0 0 0 NA Mild_Hotspot 22.8%
I363V A 363 0 0 0 NA Mild_Hotspot 16.2%
I395F A 395 0 0 0 NA Non_Hotspot 8.4%
I395L A 395 0 0 0 NA Non_Hotspot 6.9%
I395M A 395 0 0 0 NA Non_Hotspot 7.7%
I395N A 395 0 0 0 NA Non_Hotspot 12.7%
I395S A 395 0 0 0 NA Non_Hotspot 11.5%
I395T A 395 0 0 0 NA Non_Hotspot 9.4%
I395V A 395 0 0 0 NA Non_Hotspot 6.2%
I400F A 400 0 0 0 NA Hotspot 70.6%
I400L A 400 0 0 0 NA Hotspot 68.7%
I400M A 400 0 0 0 NA Hotspot 68.4%
I400N A 400 8 7 1 NA Hotspot 81.7%
I400S A 400 0 0 0 NA Hotspot 75.1%
I400T A 400 0 0 0 NA Hotspot 72.9%
I400V A 400 0 0 0 NA Hotspot 63.5%
I414F A 414 0 0 0 NA Hotspot 61.4%
I414L A 414 0 0 0 NA Hotspot 55.9%
I414M A 414 0 0 0 NA Hotspot 58.8%
I414N A 414 0 0 0 NA Hotspot 71.6%
I414S A 414 0 0 0 NA Hotspot 69.2%
I414T A 414 0 0 0 NA Hotspot 64.1%
I414V A 414 0 0 0 NA Hotspot 53.2%
I419F A 419 0 0 0 NA Hotspot 69.9%
I419L A 419 0 0 0 NA Hotspot 65.2%
I419M A 419 0 0 0 NA Hotspot 67.6%
I419N A 419 0 0 0 NA Hotspot 78.5%
I419S A 419 0 0 0 NA Hotspot 76.5%
I419T A 419 0 0 0 NA Hotspot 72.1%
I419V A 419 0 0 0 NA Hotspot 62.3%
I42F A 42 0 0 0 NA Hotspot 69.4%
I42L A 42 0 0 0 NA Hotspot 64.6%
I42M A 42 0 0 0 NA Hotspot 67%
I42N A 42 1 1 0 NA Hotspot 78.1%
I42S A 42 0 0 0 NA Hotspot 74%
I42T A 42 0 0 0 NA Hotspot 71.7%
I42V A 42 0 0 0 NA Hotspot 62.3%
I458F A 458 0 0 0 NA Hotspot 73.9%
I458L A 458 0 0 0 NA Hotspot 69.6%
I458M A 458 0 0 0 NA Hotspot 71.9%
I458N A 458 0 0 0 NA Hotspot 81.7%
I458S A 458 0 0 0 NA Hotspot 79.8%
I458T A 458 0 0 0 NA Hotspot 76%
I458V A 458 0 0 0 NA Hotspot 67.1%
I461F A 461 0 0 0 NA Hotspot 54.9%
I461L A 461 0 0 0 NA Hotspot 52.4%
I461M A 461 0 0 0 NA Hotspot 52.2%
I461N A 461 0 0 0 NA Hotspot 65.8%
I461S A 461 0 0 0 NA Hotspot 63.2%
I461T A 461 0 0 0 NA Hotspot 57.7%
I461V A 461 0 0 0 NA Hotspot 47%
I464F A 464 0 0 0 NA Hotspot 44.1%
I464L A 464 0 0 0 NA Hotspot 41.6%
I464M A 464 0 0 0 NA Hotspot 41.6%
I464N A 464 0 0 0 NA Hotspot 55.5%
I464S A 464 0 0 0 NA Hotspot 52.6%
I464T A 464 0 0 0 NA Hotspot 46.9%
I464V A 464 0 0 0 NA Hotspot 36.4%
I467F A 467 0 0 0 NA Hotspot 55.3%
I467Ins A 467 0 0 0 NA Hotspot 58.7%
I467L A 467 0 0 0 NA Hotspot 52.6%
I467M A 467 0 0 0 NA Hotspot 52.6%
I467N A 467 0 0 0 NA Hotspot 66.2%
I467S A 467 0 0 0 NA Hotspot 63.5%
I467T A 467 0 0 0 NA Hotspot 58.1%
I467V A 467 0 0 0 NA Hotspot 46.9%
I469F A 469 0 0 0 NA Hotspot 58.6%
I469L A 469 0 0 0 NA Hotspot 56.2%
I469M A 469 0 0 0 NA Hotspot 56%
I469N A 469 0 0 0 NA Hotspot 69.2%
I469S A 469 0 0 0 NA Hotspot 66.7%
I469T A 469 0 0 0 NA Hotspot 61.4%
I469V A 469 0 0 0 NA Hotspot 50.4%
I489F A 489 1 1 0 NA Hotspot 68.1%
I489L A 489 0 0 0 NA Hotspot 62.5%
I489M A 489 0 0 0 NA Hotspot 62.7%
I489N A 489 0 0 0 NA Hotspot 74.6%
I489S A 489 0 0 0 NA Hotspot 72.3%
I489T A 489 0 0 0 NA Hotspot 67.5%
I489V A 489 0 0 0 NA Hotspot 56.9%
I500Del A 500 5 5 0 LOF Hotspot 81.3%
I500F A 500 0 0 0 NA Hotspot 71.5%
I500L A 500 0 0 0 NA Hotspot 69.3%
I500M A 500 0 0 0 NA Hotspot 69.6%
I500N A 500 0 0 0 NA Hotspot 79.9%
I500S A 500 0 0 0 NA Hotspot 78%
I500T A 500 0 0 0 NA Hotspot 73.8%
I500V A 500 0 0 0 NA Hotspot 64.2%
I506F A 506 0 0 0 NA Mild_Hotspot 16.6%
I506L A 506 0 0 0 NA Mild_Hotspot 15.4%
I506M A 506 0 0 0 NA Mild_Hotspot 15.1%
I506N A 506 0 0 0 NA Mild_Hotspot 23.9%
I506S A 506 0 0 0 NA Mild_Hotspot 21.9%
I506T A 506 0 0 0 NA Mild_Hotspot 18.2%
I506V A 506 1 0 1 NA Mild_Hotspot 11.4%
I512F A 512 0 0 0 NA Mild_Hotspot 15%
I512L A 512 0 0 0 NA Mild_Hotspot 13.8%
I512M A 512 0 0 0 NA Mild_Hotspot 13.7%
I512N A 512 0 0 0 NA Mild_Hotspot 21.8%
I512S A 512 0 0 0 NA Mild_Hotspot 19.9%
I512T A 512 0 0 0 NA Mild_Hotspot 16.5%
I512V A 512 0 0 0 NA Mild_Hotspot 11.3%
I521A A 521 0 0 0 NA Non_Hotspot 11.4%
I521C A 521 0 0 0 NA Non_Hotspot 11.8%
I521F A 521 0 0 0 NA Non_Hotspot 9.2%
I521L A 521 0 0 0 NA Non_Hotspot 8.4%
I521M A 521 0 0 0 NA Non_Hotspot 8.4%
I521N A 521 0 0 0 NA Non_Hotspot 12.5%
I521S A 521 0 0 0 NA Non_Hotspot 11.3%
I521T A 521 0 0 0 NA Non_Hotspot 10.2%
I521V A 521 0 0 0 NA Non_Hotspot 6.8%
I560A A 560 0 0 0 NA Hotspot 49.1%
I560F A 560 0 0 0 NA Hotspot 43.8%
I560L A 560 0 0 0 NA Hotspot 41.3%
I560M A 560 1 0 1 NA Hotspot 37.6%
I560N A 560 0 0 0 NA Hotspot 55.3%
I560S A 560 0 0 0 NA Hotspot 52.4%
I560T A 560 0 0 0 NA Hotspot 45.3%
I560V A 560 0 0 0 NA Hotspot 36%
I567A A 567 0 0 0 NA Mild_Hotspot 30.2%
I567F A 567 0 0 0 NA Mild_Hotspot 25.8%
I567L A 567 0 0 0 NA Mild_Hotspot 23.9%
I567M A 567 1 0 1 NA Mild_Hotspot 21.5%
I567N A 567 0 0 0 NA Mild_Hotspot 35.5%
I567S A 567 0 0 0 NA Mild_Hotspot 32.9%
I567T A 567 1 0 1 NA Mild_Hotspot 25.3%
I567V A 567 0 0 0 NA Mild_Hotspot 19.9%
I571F A 571 0 0 0 NA Hotspot 78.8%
I571L A 571 1 1 0 NA Hotspot 79.3%
I571M A 571 0 0 0 NA Hotspot 77.1%
I571N A 571 0 0 0 NA Hotspot 85.5%
I571S A 571 0 0 0 NA Hotspot 84%
I571T A 571 0 0 0 NA Hotspot 80.6%
I571V A 571 1 1 0 NA Hotspot 75.2%
I583F A 583 0 0 0 NA Hotspot 34.5%
I583L A 583 0 0 0 NA Hotspot 32.1%
I583M A 583 0 0 0 NA Hotspot 32.1%
I583N A 583 0 0 0 NA Hotspot 42.7%
I583S A 583 0 0 0 NA Hotspot 39.9%
I583T A 583 0 0 0 NA Hotspot 34.6%
I583V A 583 9 1 8 NA Hotspot 19.6%
I593K A 593 1 0 1 NA Hotspot 49.6%
I593L A 593 0 0 0 NA Hotspot 38.2%
I593M A 593 0 0 0 NA Hotspot 40.9%
I593R A 593 5 2 3 Dominant LOF Hotspot 50.7%
I593T A 593 4 3 1 NA Hotspot 56.3%
I593V A 593 3 2 1 NA Hotspot 46.5%
I607F A 607 0 0 0 NA Hotspot 74.3%
I607L A 607 0 0 0 NA Hotspot 72.4%
I607M A 607 0 0 0 NA Hotspot 72.2%
I607N A 607 0 0 0 NA Hotspot 80.4%
I607S A 607 0 0 0 NA Hotspot 80.4%
I607T A 607 0 0 0 NA Hotspot 76.7%
I607V A 607 0 0 0 NA Hotspot 67.6%
I639A A 639 0 0 0 NA Hotspot 76.3%
I639F A 639 2 2 0 NA Hotspot 77.2%
I639L A 639 0 0 0 NA Hotspot 70.5%
I639M A 639 0 0 0 NA Hotspot 70.2%
I639N A 639 2 1 1 NA Hotspot 75.4%
I639S A 639 0 0 0 NA Hotspot 78.8%
I639T A 639 0 0 0 NA Hotspot 74.7%
I639V A 639 0 0 0 NA Hotspot 65.6%
I642C A 642 0 0 0 NA Hotspot 74.8%
I642Del A 642 1 1 0 NA Hotspot 74.7%
I642F A 642 0 0 0 NA Hotspot 70%
I642L A 642 0 0 0 NA Hotspot 67.6%
I642M A 642 0 0 0 NA Hotspot 67.6%
I642N A 642 0 0 0 NA Hotspot 78.6%
I642S A 642 0 0 0 NA Hotspot 76.6%
I642T A 642 0 0 0 NA Hotspot 72.3%
I642V A 642 2 1 1 NA Hotspot 60.4%
I647A A 647 0 0 0 NA Hotspot 70%
I647F A 647 0 0 0 NA Hotspot 65.3%
I647L A 647 0 0 0 NA Hotspot 63.9%
I647M A 647 0 0 0 NA Hotspot 63.9%
I647N A 647 0 0 0 NA Hotspot 75.6%
I647S A 647 0 0 0 NA Hotspot 73.4%
I647T A 647 0 0 0 NA Hotspot 68.7%
I647V A 647 0 0 0 NA Hotspot 58.5%
I655A A 655 0 0 0 NA Hotspot 53.2%
I655C A 655 0 0 0 NA Hotspot 53.2%
I655F A 655 0 0 0 NA Hotspot 46.9%
I655L A 655 0 0 0 NA Hotspot 44.1%
I655M A 655 0 0 0 NA Hotspot 44.1%
I655N A 655 0 0 0 NA Hotspot 58.2%
I655S A 655 0 0 0 NA Hotspot 55.4%
I655T A 655 0 0 0 NA Hotspot 49.6%
I655V A 655 0 0 0 NA Hotspot 38.6%
I662A A 662 0 0 0 NA Mild_Hotspot 14.3%
I662C A 662 0 0 0 NA Mild_Hotspot 14.9%
I662F A 662 0 0 0 NA Mild_Hotspot 11.6%
I662L A 662 0 0 0 NA Mild_Hotspot 10.5%
I662M A 662 0 0 0 NA Mild_Hotspot 10.5%
I662N A 662 0 0 0 NA Mild_Hotspot 17.2%
I662S A 662 0 0 0 NA Mild_Hotspot 15.6%
I662T A 662 0 0 0 NA Mild_Hotspot 12.6%
I662V A 662 0 0 0 NA Mild_Hotspot 8.6%
I663A A 663 0 0 0 NA Mild_Hotspot 19.8%
I663C A 663 0 0 0 NA Mild_Hotspot 20.5%
I663F A 663 0 0 0 NA Mild_Hotspot 16.4%
I663L A 663 0 0 0 NA Mild_Hotspot 14.9%
I663M A 663 0 0 0 NA Mild_Hotspot 14.9%
I663N A 663 0 0 0 NA Mild_Hotspot 23.6%
I663S A 663 0 0 0 NA Mild_Hotspot 21.6%
I663T A 663 0 0 0 NA Mild_Hotspot 18%
I663V A 663 0 0 0 NA Mild_Hotspot 12.3%
I684F A 684 0 0 0 NA Mild_Hotspot 15.7%
I684L A 684 0 0 0 NA Mild_Hotspot 14.4%
I684M A 684 0 0 0 NA Mild_Hotspot 14.3%
I684N A 684 0 0 0 NA Mild_Hotspot 22.8%
I684S A 684 0 0 0 NA Mild_Hotspot 20.8%
I684T A 684 0 0 0 NA Mild_Hotspot 17.3%
I684V A 684 0 0 0 NA Mild_Hotspot 11.8%
I689F A 689 0 0 0 NA Mild_Hotspot 19.1%
I689L A 689 0 0 0 NA Mild_Hotspot 17.5%
I689M A 689 0 0 0 NA Mild_Hotspot 17.6%
I689N A 689 0 0 0 NA Mild_Hotspot 27.1%
I689S A 689 0 0 0 NA Mild_Hotspot 24.9%
I689T A 689 0 0 0 NA Mild_Hotspot 20.9%
I689V A 689 0 0 0 NA Mild_Hotspot 14.5%
I711F A 711 0 0 0 NA Mild_Hotspot 15%
I711L A 711 0 0 0 NA Mild_Hotspot 13.8%
I711M A 711 0 0 0 NA Mild_Hotspot 13.7%
I711N A 711 0 0 0 NA Mild_Hotspot 21.9%
I711S A 711 0 0 0 NA Mild_Hotspot 19.9%
I711T A 711 0 0 0 NA Mild_Hotspot 16.5%
I711V A 711 10 1 9 NA Mild_Hotspot 10.7%
I728F A 728 0 0 0 NA Mild_Hotspot 29.9%
I728L A 728 0 0 0 NA Mild_Hotspot 27.8%
I728M A 728 0 0 0 NA Mild_Hotspot 27.7%
I728N A 728 0 0 0 NA Mild_Hotspot 37.6%
I728S A 728 0 0 0 NA Mild_Hotspot 35%
I728T A 728 0 0 0 NA Mild_Hotspot 32.4%
I728V A 728 0 0 0 NA Mild_Hotspot 25.6%
I782F A 782 0 0 0 NA Hotspot 66.3%
I782L A 782 0 0 0 NA Hotspot 61.6%
I782M A 782 0 0 0 NA Hotspot 63.9%
I782N A 782 1 1 0 NA Hotspot 77.7%
I782S A 782 0 0 0 NA Hotspot 73.5%
I782T A 782 0 0 0 NA Hotspot 68.8%
I782V A 782 0 0 0 NA Hotspot 58.9%
I787F A 787 0 0 0 NA Hotspot 58.9%
I787L A 787 0 0 0 NA Hotspot 56.5%
I787M A 787 0 0 0 NA Hotspot 56.5%
I787N A 787 0 0 0 NA Hotspot 69.4%
I787S A 787 0 0 0 NA Hotspot 66.9%
I787T A 787 0 0 0 NA Hotspot 61.6%
I787V A 787 0 0 0 NA Hotspot 50.9%
I789F A 789 0 0 0 NA Hotspot 52.5%
I789L A 789 0 0 0 NA Hotspot 49.8%
I789M A 789 0 0 0 NA Hotspot 49.7%
I789N A 789 0 0 0 NA Hotspot 63.7%
I789S A 789 0 0 0 NA Hotspot 60.9%
I789T A 789 0 0 0 NA Hotspot 55.3%
I789V A 789 0 0 0 NA Hotspot 44.5%
I798F A 798 0 0 0 NA Hotspot 60%
I798L A 798 0 0 0 NA Hotspot 57.4%
I798M A 798 0 0 0 NA Hotspot 57.3%
I798N A 798 0 0 0 NA Hotspot 70.4%
I798S A 798 0 0 0 NA Hotspot 67.9%
I798T A 798 0 0 0 NA Hotspot 62.8%
I798V A 798 0 0 0 NA Hotspot 51.8%
I804F A 804 0 0 0 NA Hotspot 42.5%
I804L A 804 0 0 0 NA Hotspot 40%
I804M A 804 0 0 0 NA Hotspot 40%
I804N A 804 0 0 0 NA Hotspot 51%
I804S A 804 0 0 0 NA Hotspot 48.2%
I804T A 804 0 0 0 NA Hotspot 42.5%
I804V A 804 0 0 0 NA Hotspot 34.9%
I82Del A 82 1 0 1 NA Hotspot 58.3%
I82dup A 82 1 1 0 NA Hotspot 67.4%
I82F A 82 0 0 0 NA Hotspot 61.7%
I82Ins A 82 1 1 0 NA Hotspot 67.4%
I82L A 82 0 0 0 NA Hotspot 56.4%
I82M A 82 0 0 0 NA Hotspot 47.9%
I82N A 82 0 0 0 NA Hotspot 69.2%
I82S A 82 0 0 0 NA Hotspot 66.7%
I82T A 82 2 2 0 NA Hotspot 69.9%
I82V A 82 0 0 0 NA Hotspot 56.4%
I833F A 833 0 0 0 NA Mild_Hotspot 29.7%
I833L A 833 0 0 0 NA Mild_Hotspot 27.5%
I833M A 833 0 0 0 NA Mild_Hotspot 27.4%
I833N A 833 0 0 0 NA Mild_Hotspot 40.2%
I833S A 833 0 0 0 NA Mild_Hotspot 37.4%
I833T A 833 0 0 0 NA Mild_Hotspot 32.2%
I833V A 833 0 0 0 NA Mild_Hotspot 23.2%
I858F A 858 0 0 0 NA Hotspot 41.9%
I858L A 858 0 0 0 NA Hotspot 36.9%
I858M A 858 0 0 0 NA Hotspot 39.3%
I858N A 858 0 0 0 NA Hotspot 53.2%
I858S A 858 0 0 0 NA Hotspot 50.3%
I858T A 858 1 1 0 NA Hotspot 49.4%
I858V A 858 1 0 1 NA Hotspot 33.2%
I868F A 868 0 0 0 NA Non_Hotspot 9.6%
I868L A 868 0 0 0 NA Non_Hotspot 7.9%
I868M A 868 0 0 0 NA Non_Hotspot 8.7%
I868N A 868 0 0 0 NA Non_Hotspot 13%
I868S A 868 0 0 0 NA Non_Hotspot 11.9%
I868T A 868 0 0 0 NA Non_Hotspot 10.7%
I868V A 868 0 0 0 NA Non_Hotspot 7.9%
I96F A 96 0 0 0 NA Hotspot 46.1%
I96L A 96 0 0 0 NA Hotspot 43.9%
I96M A 96 0 0 0 NA Hotspot 40.7%
I96N A 96 0 0 0 NA Hotspot 54.5%
I96S A 96 0 0 0 NA Hotspot 51.6%
I96T A 96 5 2 3 NA Hotspot 45.7%
I96V A 96 2 1 1 Normal Hotspot 41.1%
I997F A 997 0 0 0 NA Hotspot 41%
I997L A 997 0 0 0 NA Hotspot 38.8%
I997M A 997 0 0 0 NA Hotspot 33.2%
I997N A 997 0 0 0 NA Hotspot 43.7%
I997S A 997 0 0 0 NA Hotspot 40.9%
I997T A 997 0 0 0 NA Hotspot 35.5%
I997V A 997 0 0 0 NA Hotspot 36.1%
K101E A 101 1 1 0 NA Hotspot 76.7%
K101I A 101 0 0 0 NA Hotspot 83.5%
K101N A 101 0 0 0 NA Hotspot 78.2%
K101Q A 101 0 0 0 NA Hotspot 76%
K101R A 101 0 0 0 NA Hotspot 76.2%
K101T A 101 0 0 0 NA Hotspot 80%
K116E A 116 0 0 0 NA Non_Hotspot 9.9%
K116M A 116 0 0 0 NA Non_Hotspot 12.2%
K116N A 116 0 0 0 NA Non_Hotspot 11.1%
K116Q A 116 1 0 1 NA Non_Hotspot 9.1%
K116R A 116 0 0 0 NA Non_Hotspot 9.2%
K116T A 116 0 0 0 NA Non_Hotspot 12.2%
K135E A 135 0 0 0 NA Non_Hotspot 5.3%
K135M A 135 0 0 0 NA Non_Hotspot 12.2%
K135N A 135 0 0 0 NA Non_Hotspot 8.2%
K135Q A 135 0 0 0 NA Non_Hotspot 7.3%
K135R A 135 0 0 0 NA Non_Hotspot 9%
K135T A 135 0 0 0 NA Non_Hotspot 10%
K161E A 161 0 0 0 NA Mild_Hotspot 20.6%
K161M A 161 0 0 0 NA Mild_Hotspot 22.5%
K161N A 161 0 0 0 NA Mild_Hotspot 18.8%
K161Q A 161 0 0 0 NA Mild_Hotspot 20.7%
K161R A 161 0 0 0 NA Mild_Hotspot 11.7%
K161T A 161 0 0 0 NA Mild_Hotspot 20.7%
K166E A 166 0 0 0 NA Hotspot 43%
K166M A 166 0 0 0 NA Hotspot 48.2%
K166N A 166 0 0 0 NA Hotspot 34.9%
K166Q A 166 0 0 0 NA Hotspot 40.3%
K166R A 166 0 0 0 NA Hotspot 30%
K166T A 166 0 0 0 NA Hotspot 45.8%
K21E A 21 0 0 0 NA Hotspot 58.7%
K21M A 21 0 0 0 NA Hotspot 63.9%
K21N A 21 0 0 0 NA Hotspot 61.5%
K21Q A 21 0 0 0 NA Hotspot 55.9%
K21R A 21 0 0 0 NA Hotspot 56.3%
K21T A 21 0 0 0 NA Hotspot 63.9%
K28E A 28 14 2 12 LOF Hotspot 25.7%
K28M A 28 0 0 0 NA Hotspot 48.7%
K28N A 28 0 0 0 NA Hotspot 46.2%
K28Q A 28 0 0 0 NA Hotspot 43%
K28R A 28 0 0 0 NA Hotspot 40.6%
K28T A 28 0 0 0 NA Hotspot 48.7%
K332E A 332 0 0 0 NA Mild_Hotspot 11.2%
K332M A 332 0 0 0 NA Mild_Hotspot 13.6%
K332N A 332 0 0 0 NA Mild_Hotspot 12.4%
K332Q A 332 0 0 0 NA Mild_Hotspot 8.3%
K332R A 332 0 0 0 NA Mild_Hotspot 8.3%
K332T A 332 0 0 0 NA Mild_Hotspot 11.1%
K344E A 344 0 0 0 NA Non_Hotspot 7.3%
K344M A 344 0 0 0 NA Non_Hotspot 9%
K344N A 344 0 0 0 NA Non_Hotspot 6.7%
K344Q A 344 0 0 0 NA Non_Hotspot 5.9%
K344R A 344 0 0 0 NA Non_Hotspot 5.3%
K344T A 344 0 0 0 NA Non_Hotspot 8.1%
K362E A 362 0 0 0 NA Mild_Hotspot 15%
K362M A 362 0 0 0 NA Mild_Hotspot 18.1%
K362N A 362 0 0 0 NA Mild_Hotspot 16.7%
K362Q A 362 0 0 0 NA Mild_Hotspot 13.5%
K362R A 362 0 0 0 NA Mild_Hotspot 12.3%
K362T A 362 0 0 0 NA Mild_Hotspot 16.5%
K364E A 364 0 0 0 NA Mild_Hotspot 31%
K364M A 364 0 0 0 NA Mild_Hotspot 24.2%
K364N A 364 0 0 0 NA Mild_Hotspot 31%
K364Q A 364 0 0 0 NA Mild_Hotspot 28.5%
K364R A 364 0 0 0 NA Mild_Hotspot 22.2%
K364T A 364 0 0 0 NA Mild_Hotspot 31.1%
K373E A 373 0 0 0 NA Non_Hotspot 8.7%
K373M A 373 0 0 0 NA Non_Hotspot 8.7%
K373N A 373 0 0 0 NA Non_Hotspot 9.9%
K373Q A 373 0 0 0 NA Non_Hotspot 7.9%
K373R A 373 0 0 0 NA Non_Hotspot 7.1%
K373T A 373 0 0 0 NA Non_Hotspot 9.7%
K389E A 389 0 0 0 NA Non_Hotspot 8.8%
K389M A 389 0 0 0 NA Non_Hotspot 12.1%
K389N A 389 0 0 0 NA Non_Hotspot 9.9%
K389Q A 389 0 0 0 NA Non_Hotspot 8.8%
K389R A 389 0 0 0 NA Non_Hotspot 8%
K389T A 389 0 0 0 NA Non_Hotspot 10.9%
K407D A 407 0 0 0 NA Hotspot 36.5%
K407E A 407 0 0 0 NA Hotspot 30.1%
K407M A 407 0 0 0 NA Hotspot 37.8%
K407N A 407 0 0 0 NA Hotspot 32.7%
K407Q A 407 0 0 0 NA Hotspot 30.1%
K407R A 407 0 0 0 NA Hotspot 27.7%
K407T A 407 0 0 0 NA Hotspot 35.1%
K434E A 434 0 0 0 NA Mild_Hotspot 20%
K434M A 434 0 0 0 NA Mild_Hotspot 23.7%
K434N A 434 0 0 0 NA Mild_Hotspot 13.8%
K434Q A 434 0 0 0 NA Mild_Hotspot 20%
K434R A 434 0 0 0 NA Mild_Hotspot 20%
K434T A 434 0 0 0 NA Mild_Hotspot 20%
K495E A 495 0 0 0 NA Hotspot 63.6%
K495M A 495 0 0 0 NA Hotspot 71.1%
K495N A 495 0 0 0 NA Hotspot 66.5%
K495Q A 495 0 0 0 NA Hotspot 63.7%
K495R A 495 0 0 0 NA Hotspot 61.2%
K495T A 495 0 0 0 NA Hotspot 68.8%
K525A A 525 0 0 0 NA Mild_Hotspot 16.5%
K525C A 525 0 0 0 NA Mild_Hotspot 21.7%
K525D A 525 0 0 0 NA Mild_Hotspot 14.6%
K525E A 525 0 0 0 NA Mild_Hotspot 11.2%
K525M A 525 0 0 0 NA Mild_Hotspot 13.7%
K525N A 525 1 0 1 NA Mild_Hotspot 11.3%
K525Q A 525 0 0 0 NA Mild_Hotspot 11.4%
K525R A 525 0 0 0 NA Mild_Hotspot 10.3%
K525T A 525 0 0 0 NA Mild_Hotspot 13.7%
K525W A 525 0 0 0 NA Mild_Hotspot 19.9%
K538A A 538 0 0 0 NA Hotspot 42.1%
K538C A 538 0 0 0 NA Hotspot 50.3%
K538D A 538 0 0 0 NA Hotspot 38.8%
K538E A 538 0 0 0 NA Hotspot 32.2%
K538M A 538 0 0 0 NA Hotspot 40.1%
K538N A 538 0 0 0 NA Hotspot 34.8%
K538Q A 538 0 0 0 NA Hotspot 32.6%
K538R A 538 0 0 0 NA Hotspot 29.9%
K538T A 538 0 0 0 NA Hotspot 37.4%
K538W A 538 0 0 0 NA Hotspot 47.9%
K595C A 595 0 0 0 NA Hotspot 79.3%
K595E A 595 4 2 2 NA Hotspot 61%
K595I A 595 0 0 0 NA Hotspot 74.6%
K595N A 595 2 2 0 NA Hotspot 73%
K595Q A 595 0 0 0 NA Hotspot 65.1%
K595R A 595 0 0 0 NA Hotspot 62.5%
K595T A 595 0 0 0 NA Hotspot 70.1%
K608E A 608 0 0 0 NA Hotspot 74.9%
K608M A 608 0 0 0 NA Hotspot 80.6%
K608N A 608 0 0 0 NA Hotspot 77.2%
K608Q A 608 0 0 0 NA Hotspot 74.9%
K608R A 608 0 0 0 NA Hotspot 72.9%
K608T A 608 0 0 0 NA Hotspot 79%
K610E A 610 0 0 0 NA Hotspot 75.8%
K610M A 610 0 0 0 NA Hotspot 81.5%
K610N A 610 0 0 0 NA Hotspot 77.8%
K610Q A 610 0 0 0 NA Hotspot 75.9%
K610R A 610 0 0 0 NA Hotspot 73.8%
K610S A 610 0 0 0 NA Hotspot 80.1%
K610T A 610 0 0 0 NA Hotspot 79.7%
K638D A 638 1 1 0 NA Hotspot 82.2%
K638Del A 638 19 13 6 NA Hotspot 72.2%
K638E A 638 4 4 0 NA Hotspot 83.2%
K638M A 638 0 0 0 NA Hotspot 81.8%
K638N A 638 0 0 0 NA Hotspot 78%
K638Q A 638 0 0 0 NA Hotspot 76.2%
K638R A 638 4 3 1 NA Hotspot 74.3%
K638T A 638 0 0 0 NA Hotspot 80%