F881S Summary

KCNH2 F881S was found in 0 papers (see below) with a total of 0 carriers: 0 had LQT2. F881S is not present in gnomAD. F881S has been functionally characterized in 0 papers. This residue is located in a Non_Hotspot region for LQT2.

In silico predictions, functional data (if available), and location in structure are equivalent to observing 9 individuals unaffected with LQT2 and 1 individuals affected with LQT2.


F881S Reported Clinical Data

PMID Year Carriers Unaffected LQT2 Other disease
Summary totals might not agree with the literature table because of duplicate patients, which were excluded from the total counts.

F881S Predictions

PROVEAN scores less than -2 are considered deleterious. REVEL scores higher than 0.5 or 0.75 is considered likely pathogenic (higher sensitivity with the former cutoff, higher specificity with the latter cutoff). A PolyPhen-2 score of 0.85 or greater is considered likely pathogenic. PAM scores reflect the chemistry difference between WT and variant amino acid (more negative being greater difference between the two). BLAST-PSSM reflects the evolutionary conservation of residue substitutions, more negative numbers indicate fewer observations of the specific substitution than is expected.

PAM Score REVEL Score PROVEAN Score Polyphen2 Score BLAST-PSSM
NA 0.771 -2.616 0.03 -1

F881S has 30 neighbors (found in individuals) within 15 ångströms

A residue within a folded protein on average has nearest neighbors that fall roughly into two shells: a "nearest" neighbor around 5-6 angstroms and a second shell around 11 angstroms. NOTE: some residues appear multiple times at different distances. This results from the fact that the functional Kv11.1 channel is a homotetramer and occasionally the same residue from multiple subunits is present within the 15A window. All variants shown in the rightmost column have been observed in at least one individual in the literature or gnomAD.

ResidueNumber Distance(Å) Variants
866 14.7 N866S N866X
867 14.2 M867T
868 13.7
869 13.2 P869L
870 12.6
871 12 S871F S871X
872 11.4 P872fsX P872L
873 10.7 G873C G873fsX G873S G873X
874 10.1
875 9.3 T875M T875X
876 8.5 E876fsX E876X
877 7.6
878 6.6 E878D
879 5.4
880 3.8 G880V
882 3.8 S882G
883 5.4 R883G R883Q R883W R883X
884 6.6 Q884X
885 7.6 R885C R885H R885P R885S R885X
886 8.5 K886fsX
887 9.3 R887C R887G R887H R887S
888 10.1 K888X
889 10.7 L889M L889V
890 11.4 S890C
891 12 F891X
892 12.6 R892C R892H
893 13.2 R893X
894 13.7 R894C R894fsX R894H R894L R894X
895 14.2 T895M T895R
896 14.7 D896fsX