Search SCN5A Variants (search from cDNA/chromosome coordinates)

Two diseases most commonly associated with variants in SCN5A are Brugada Syndrome (BrS1; OMIM: 601144) and long QT type 3 (LQT3; OMIM: 603830). Coding variants are referenced to isoform Q14524-1 (ENST00000333535.9) to match convention. Total Carriers is the number of heterozygotes diagnosed with LQT3, BrS1, Unaffected with disease, and found in the genome aggregation database (gnomAD). Other is the number of heterozygoes diagnosed with a cardiac disease which is not LQT3 or BrS1. Click variant link for more details. Functional classification of variants was done according to the following criteria: Loss-of-function (LOF) < 10% peak, partial LOF <50% peak, mild LOF 50-75% peak, normal 75-125% peak, Gain-of-function (GOF) > 125% peak current or >300% late current, partial LOF >10 mv rightward shift in V1/2 activation. Structually, a "Non_Hotspot" variant was surrounded by variants with <10% BrS1 penetrance on average, a "Mild_Hotspot" variant was surrounded by variants with between 10% and 40% BrS1 penetrance, on average, a "Hotspot" variant was surrounded by variants with greater than 40% BrS1 penetrance, on average.

Location Ch.03	Variant	Residue	Total Carriers	LQT3	BrS1	Other	Unaffected & gnomAD	Function	BrS1 Hotspot	BrS1 Penetrance	LQT3 Hotspot	LQT3 Penetrance
38622633G>T	A1006D	1006	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38622633G>C	A1006G	1006	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	4%
38622634C>G	A1006P	1006	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38622634C>A	A1006S	1006	1	0	0	0	1	NA	Non_Hotspot	4%	Non_Hotspot	4%
38622634C>T	A1006T	1006	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	4%
38622633G>A	A1006V	1006	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38622501G>T	A1050D	1050	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38622501G>C	A1050G	1050	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38622502C>G	A1050P	1050	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38622502C>A	A1050S	1050	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38622502C>T	A1050T	1050	2	0	0	0	2	NA	Non_Hotspot	7%	Non_Hotspot	5%
38622501G>A	A1050V	1050	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38622495G>T	A1052D	1052	1	0	0	0	1	NA	Non_Hotspot	8%	Non_Hotspot	5%
38622495G>C	A1052G	1052	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	2%
38622496C>G	A1052P	1052	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38622496C>A	A1052S	1052	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	3%
38622496C>T	A1052T	1052	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38622495G>A	A1052V	1052	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38671874G>T	A107D	107	0	0	0	0	0	NA	Mild_Hotspot	27%	Mild_Hotspot	12%
38671874G>C	A107G	107	0	0	0	0	0	NA	Mild_Hotspot	27%	Mild_Hotspot	12%
38671875C>G	A107P	107	0	0	0	0	0	NA	Mild_Hotspot	27%	Mild_Hotspot	12%
38671875C>A	A107S	107	0	0	0	0	0	NA	Mild_Hotspot	26%	Mild_Hotspot	12%
38671875C>T	A107T	107	0	0	0	0	0	NA	Mild_Hotspot	27%	Mild_Hotspot	12%
38671874G>A	A107V	107	0	0	0	0	0	NA	Mild_Hotspot	27%	Mild_Hotspot	12%
38620952G>T	A1088D	1088	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620952G>C	A1088G	1088	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620953C>G	A1088P	1088	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620953C>A	A1088S	1088	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620953C>T	A1088T	1088	31	0	0	0	31	NA	Non_Hotspot	1%	Non_Hotspot	1%
38620952G>A	A1088V	1088	1	0	0	0	1	NA	Non_Hotspot	10%	Non_Hotspot	3%
38620916G>T	A1100E	1100	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	4%
38620916G>C	A1100G	1100	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	4%
38620917C>G	A1100P	1100	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	4%
38620917C>A	A1100S	1100	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	4%
38620917C>T	A1100T	1100	1	0	0	0	1	NA	Non_Hotspot	3%	Non_Hotspot	4%
38620916G>A	A1100V	1100	16	1	0	1	15	NA	Non_Hotspot	5%	Non_Hotspot	7%
38620910G>T	A1102D	1102	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	3%
38620910G>C	A1102G	1102	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620911C>G	A1102P	1102	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620911C>A	A1102S	1102	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620911C>T	A1102T	1102	3	0	0	0	3	NA	Non_Hotspot	0%	Non_Hotspot	3%
38620910G>A	A1102V	1102	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620898G>T	A1106D	1106	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620898G>C	A1106G	1106	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620899C>G	A1106P	1106	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620899C>A	A1106S	1106	0	0	0	1	0	NA	Non_Hotspot	9%	Non_Hotspot	1%
38620899C>T	A1106T	1106	2	0	0	0	2	NA	Non_Hotspot	5%	Non_Hotspot	1%
38620898G>A	A1106V	1106	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38620892G>T	A1108D	1108	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38620892G>C	A1108G	1108	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38620893C>G	A1108P	1108	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38620893C>A	A1108S	1108	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38620893C>T	A1108T	1108	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38620892G>A	A1108V	1108	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38671865G>T	A110D	110	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	15%
38671865G>C	A110G	110	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	14%
38671866C>G	A110P	110	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	15%
38671866C>A	A110S	110	0	0	0	0	0	NA	Mild_Hotspot	19%	Mild_Hotspot	14%
38671866C>T	A110T	110	5	1	0	0	4	NA	Mild_Hotspot	16%	Mild_Hotspot	14%
38671865G>A	A110V	110	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	15%
38620886G>T	A1110E	1110	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	7%
38620886G>C	A1110G	1110	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	7%
38620887C>G	A1110P	1110	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	8%
38620887C>A	A1110S	1110	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	7%
38620887C>T	A1110T	1110	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	7%
38620886G>A	A1110V	1110	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	7%
38620877G>T	A1113D	1113	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	10%
38620877G>C	A1113G	1113	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	10%
38620878C>G	A1113P	1113	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	10%
38620878C>A	A1113S	1113	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	10%
38620878C>T	A1113T	1113	1	0	0	0	1	NA	Non_Hotspot	4%	Mild_Hotspot	12%
38620877G>A	A1113V	1113	7	0	1	0	6	Normal	Non_Hotspot	8%	Mild_Hotspot	5%
38620853G>T	A1121E	1121	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620853G>C	A1121G	1121	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	3%
38620854C>G	A1121P	1121	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620854C>A	A1121S	1121	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	3%
38620854C>T	A1121T	1121	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	3%
38620853G>A	A1121V	1121	11	0	0	0	11	NA	Non_Hotspot	2%	Non_Hotspot	2%
38620841G>T	A1125D	1125	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38620841G>C	A1125G	1125	3	0	0	0	3	NA	Non_Hotspot	2%	Non_Hotspot	5%
38620842C>G	A1125P	1125	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38620842C>A	A1125S	1125	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620842C>T	A1125T	1125	1	0	0	0	1	NA	Non_Hotspot	2%	Non_Hotspot	2%
38620841G>A	A1125V	1125	2	0	0	0	2	NA	Non_Hotspot	2%	Non_Hotspot	6%
38618238G>T	A1142E	1142	0	0	0	0	0	NA	Mild_Hotspot	25%	Non_Hotspot	3%
38618238G>C	A1142G	1142	0	0	0	0	0	NA	Mild_Hotspot	24%	Non_Hotspot	3%
38618239C>G	A1142P	1142	0	0	0	0	0	NA	Mild_Hotspot	25%	Non_Hotspot	4%
38618239C>A	A1142S	1142	0	0	0	0	0	NA	Mild_Hotspot	24%	Non_Hotspot	3%
38618239C>T	A1142T	1142	0	0	0	0	0	NA	Mild_Hotspot	25%	Non_Hotspot	3%
38618238G>A	A1142V	1142	0	0	0	0	0	NA	Mild_Hotspot	24%	Non_Hotspot	3%
38618220G>T	A1148D	1148	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38618220G>C	A1148G	1148	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38618221C>G	A1148P	1148	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38618221C>A	A1148S	1148	1	0	0	0	1	NA	Non_Hotspot	3%	Non_Hotspot	3%
38618221C>T	A1148T	1148	7	0	0	0	7	NA	Non_Hotspot	3%	Non_Hotspot	1%
38618220G>A	A1148V	1148	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38616915G>T	A1180E	1180	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38616915G>C	A1180G	1180	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38616916C>G	A1180P	1180	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38616916C>A	A1180S	1180	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38616916C>T	A1180T	1180	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38616915G>A	A1180V	1180	46	1	0	6	45	NA	Non_Hotspot	2%	Non_Hotspot	2%
38616897G>T	A1186D	1186	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	7%
38616897G>C	A1186G	1186	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	7%
38616898C>G	A1186P	1186	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	8%
38616898C>A	A1186S	1186	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	8%
38616898C>T	A1186T	1186	7	1	0	0	6	NA	Non_Hotspot	4%	Non_Hotspot	8%
38616897G>A	A1186V	1186	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	8%
38616792G>T	A1221E	1221	0	0	0	0	0	NA	Mild_Hotspot	15%	Mild_Hotspot	19%
38616792G>C	A1221G	1221	0	0	0	0	0	NA	Mild_Hotspot	15%	Mild_Hotspot	19%
38616793C>G	A1221P	1221	0	0	0	0	0	NA	Mild_Hotspot	15%	Mild_Hotspot	19%
38616793C>A	A1221S	1221	0	0	0	0	0	NA	Mild_Hotspot	14%	Mild_Hotspot	18%
38616793C>T	A1221T	1221	0	0	0	0	0	NA	Mild_Hotspot	14%	Mild_Hotspot	18%
38616792G>A	A1221V	1221	5	1	0	0	4	NA	Mild_Hotspot	11%	Mild_Hotspot	19%
38608072G>T	A1223D	1223	0	0	0	0	0	NA	Mild_Hotspot	26%	Mild_Hotspot	24%
38608072G>C	A1223G	1223	0	0	0	0	0	NA	Mild_Hotspot	26%	Mild_Hotspot	23%
38608073C>G	A1223P	1223	0	0	0	0	0	NA	Mild_Hotspot	26%	Mild_Hotspot	24%
38608073C>A	A1223S	1223	0	0	0	0	0	NA	Mild_Hotspot	26%	Mild_Hotspot	23%
38608073C>T	A1223T	1223	0	0	0	0	0	NA	Mild_Hotspot	26%	Mild_Hotspot	23%
38608072G>A	A1223V	1223	0	0	0	0	0	NA	Mild_Hotspot	26%	Mild_Hotspot	23%
38671826G>T	A123E	123	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	4%
38671826G>C	A123G	123	1	0	0	0	1	NA	Mild_Hotspot	16%	Non_Hotspot	3%
38671827C>G	A123P	123	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	4%
38671827C>A	A123S	123	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	3%
38671827C>T	A123T	123	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	2%
38671826G>A	A123V	123	19	0	0	0	19	NA	Mild_Hotspot	7%	Non_Hotspot	1%
38608015G>T	A1242D	1242	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	4%
38608015G>C	A1242G	1242	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	4%
38608016C>G	A1242P	1242	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	4%
38608016C>A	A1242S	1242	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	4%
38608016C>T	A1242T	1242	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	4%
38608015G>A	A1242V	1242	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	4%
38671823G>T	A124D	124	1	0	1	0	0	Partial_LOF	Hotspot	43%	Non_Hotspot	3%
38671823G>C	A124G	124	0	0	0	0	0	NA	Hotspot	37%	Non_Hotspot	4%
38671824C>G	A124P	124	0	0	0	0	0	NA	Hotspot	37%	Non_Hotspot	5%
38671824C>A	A124S	124	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	4%
38671824C>T	A124T	124	0	0	0	0	0	NA	Hotspot	37%	Non_Hotspot	4%
38671823G>A	A124V	124	0	0	0	0	0	NA	Hotspot	37%	Non_Hotspot	4%
38607961G>T	A1260D	1260	1	0	0	3	1	NA	Non_Hotspot	8%	Non_Hotspot	5%
38607961G>C	A1260G	1260	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38607962C>G	A1260P	1260	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	5%
38607962C>A	A1260S	1260	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38607962C>T	A1260T	1260	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38607961G>A	A1260V	1260	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38607931G>T	A1270D	1270	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	9%
38607931G>C	A1270G	1270	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	9%
38607932C>G	A1270P	1270	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	9%
38607932C>A	A1270S	1270	1	0	0	0	1	NA	Mild_Hotspot	17%	Non_Hotspot	9%
38607932C>T	A1270T	1270	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	9%
38607931G>A	A1270V	1270	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	9%
38604006G>T	A1288D	1288	0	0	0	0	0	NA	Hotspot	59%	Non_Hotspot	6%
38604006G>C	A1288G	1288	1	0	1	0	0	NA	Hotspot	61%	Non_Hotspot	5%
38604007C>G	A1288P	1288	0	0	0	0	0	NA	Hotspot	59%	Non_Hotspot	6%
38604007C>A	A1288S	1288	0	0	0	0	0	NA	Hotspot	58%	Non_Hotspot	6%
38604007C>T	A1288T	1288	0	0	0	0	0	NA	Hotspot	58%	Non_Hotspot	6%
38604006G>A	A1288V	1288	0	0	0	0	0	NA	Hotspot	58%	Non_Hotspot	6%
38603988G>T	A1294D	1294	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	8%
38603988G>C	A1294G	1294	8	0	0	0	8	NA	Non_Hotspot	1%	Non_Hotspot	5%
38603989C>G	A1294P	1294	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	8%
38603989C>A	A1294S	1294	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	7%
38603989C>T	A1294T	1294	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	8%
38603988G>A	A1294V	1294	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	7%
38603949G>T	A1307E	1307	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	5%
38603949G>C	A1307G	1307	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	5%
38603950C>G	A1307P	1307	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	5%
38603950C>A	A1307S	1307	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	5%
38603950C>T	A1307T	1307	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	5%
38603949G>A	A1307V	1307	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	5%
38603931G>T	A1313D	1313	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	5%
38603931G>C	A1313G	1313	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	5%
38603932C>G	A1313P	1313	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	5%
38603932C>A	A1313S	1313	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	5%
38603932C>T	A1313T	1313	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	5%
38603931G>A	A1313V	1313	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	5%
38601906G>T	A1326D	1326	0	0	0	0	0	NA	Mild_Hotspot	14%	Hotspot	54%
38601906G>C	A1326G	1326	0	0	0	0	0	NA	Mild_Hotspot	13%	Hotspot	53%
38601907C>G	A1326P	1326	0	0	0	0	0	NA	Mild_Hotspot	14%	Hotspot	54%
38601907C>A	A1326S	1326	1	1	0	0	0	NA	Mild_Hotspot	12%	Hotspot	55%
38601907C>T	A1326T	1326	0	0	0	0	0	NA	Mild_Hotspot	14%	Hotspot	53%
38601906G>A	A1326V	1326	0	0	0	0	0	NA	Mild_Hotspot	14%	Hotspot	54%
38601894G>T	A1330D	1330	1	1	0	0	0	NA	Non_Hotspot	9%	Hotspot	56%
38601894G>C	A1330G	1330	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	53%
38601895C>G	A1330P	1330	1	1	0	1	0	Normal	Non_Hotspot	8%	Hotspot	54%
38601895C>A	A1330S	1330	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	53%
38601895C>T	A1330T	1330	7	5	0	0	2	GOF	Non_Hotspot	5%	Hotspot	58%
38601894G>A	A1330V	1330	0	0	0	0	0	NA	Non_Hotspot	10%	Hotspot	53%
38601813G>T	A1357E	1357	0	0	0	0	0	NA	Mild_Hotspot	23%	Non_Hotspot	5%
38601813G>C	A1357G	1357	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	5%
38601814C>G	A1357P	1357	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	5%
38601814C>A	A1357S	1357	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	5%
38601814C>T	A1357T	1357	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	5%
38601813G>A	A1357V	1357	20	1	0	0	19	NA	Mild_Hotspot	11%	Non_Hotspot	4%
38601663G>T	A1407D	1407	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	4%
38601663G>C	A1407G	1407	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	4%
38601664C>G	A1407P	1407	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	4%
38601664C>A	A1407S	1407	0	0	0	0	0	NA	Hotspot	47%	Non_Hotspot	3%
38601664C>T	A1407T	1407	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	4%
38601663G>A	A1407V	1407	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	4%
38601651G>T	A1411D	1411	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	4%
38601651G>C	A1411G	1411	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	4%
38601652C>G	A1411P	1411	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	4%
38601652C>A	A1411S	1411	0	0	0	0	0	NA	Hotspot	46%	Non_Hotspot	3%
38601652C>T	A1411T	1411	0	0	0	0	0	NA	Hotspot	47%	Non_Hotspot	4%
38601651G>A	A1411V	1411	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	4%
38598774G>T	A1416E	1416	1	0	1	0	0	NA	Hotspot	62%	Non_Hotspot	3%
38598774G>C	A1416G	1416	1	0	1	0	0	NA	Hotspot	61%	Non_Hotspot	2%
38598775C>G	A1416P	1416	0	0	0	0	0	NA	Hotspot	59%	Non_Hotspot	4%
38598775C>A	A1416S	1416	0	0	0	0	0	NA	Hotspot	58%	Non_Hotspot	4%
38598775C>T	A1416T	1416	0	0	0	0	0	NA	Hotspot	59%	Non_Hotspot	4%
38598774G>A	A1416V	1416	0	0	0	0	0	NA	Hotspot	59%	Non_Hotspot	4%
38598741G>T	A1427E	1427	1	0	0	0	1	NA	Hotspot	35%	Non_Hotspot	4%
38598741G>C	A1427G	1427	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	5%
38598742C>G	A1427P	1427	0	0	0	0	0	NA	Hotspot	37%	Non_Hotspot	5%
38598742C>A	A1427S	1427	1	0	1	0	0	Partial_LOF	Hotspot	41%	Non_Hotspot	3%
38598742C>T	A1427T	1427	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	5%
38598741G>A	A1427V	1427	0	0	0	0	0	NA	Hotspot	37%	Non_Hotspot	5%
38598738G>T	A1428D	1428	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	6%
38598738G>C	A1428G	1428	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	6%
38598739C>G	A1428P	1428	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	6%
38598739C>A	A1428S	1428	19	1	8	0	10	Mild_LOF	Hotspot	40%	Non_Hotspot	5%
38598739C>T	A1428T	1428	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	6%
38598738G>A	A1428V	1428	6	0	4	0	2	LOF	Hotspot	47%	Non_Hotspot	3%
38597199G>T	A1497D	1497	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	47%
38597199G>C	A1497G	1497	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	47%
38597200C>G	A1497P	1497	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	47%
38597200C>A	A1497S	1497	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	46%
38597200C>T	A1497T	1497	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	46%
38597199G>A	A1497V	1497	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	47%
38663927G>T	A149D	149	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38663927G>C	A149G	149	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38663928C>G	A149P	149	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38663928C>A	A149S	149	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38663928C>T	A149T	149	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38663927G>A	A149V	149	0	0	0	1	0	NA	Non_Hotspot	11%	Non_Hotspot	11%
38595997G>T	A1529D	1529	0	0	0	0	0	NA	Mild_Hotspot	23%	Non_Hotspot	6%
38595997G>C	A1529G	1529	0	0	0	0	0	NA	Mild_Hotspot	23%	Non_Hotspot	6%
38595998C>G	A1529P	1529	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	6%
38595998C>A	A1529S	1529	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	6%
38595998C>T	A1529T	1529	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	6%
38595997G>A	A1529V	1529	0	0	0	0	0	NA	Mild_Hotspot	21%	Non_Hotspot	6%
38595901G>T	A1561D	1561	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	21%
38595901G>C	A1561G	1561	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	20%
38595902C>G	A1561P	1561	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	21%
38595902C>A	A1561S	1561	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	20%
38595902C>T	A1561T	1561	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	20%
38595901G>A	A1561V	1561	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	20%
38595877G>T	A1569D	1569	0	0	0	0	0	NA	Hotspot	44%	Non_Hotspot	4%
38595877G>C	A1569G	1569	0	0	0	0	0	NA	Hotspot	42%	Non_Hotspot	2%
38595878C>G	A1569P	1569	1	0	1	1	0	NA	Hotspot	49%	Non_Hotspot	1%
38595878C>A	A1569S	1569	0	0	0	0	0	NA	Hotspot	43%	Non_Hotspot	3%
38595878C>T	A1569T	1569	0	0	0	0	0	NA	Hotspot	43%	Non_Hotspot	3%
38595877G>A	A1569V	1569	0	0	0	0	0	NA	Hotspot	42%	Non_Hotspot	2%
38595844G>T	A1580D	1580	0	0	0	0	0	NA	Mild_Hotspot	23%	Non_Hotspot	3%
38595844G>C	A1580G	1580	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	3%
38595845C>G	A1580P	1580	0	0	0	0	0	NA	Mild_Hotspot	23%	Non_Hotspot	3%
38595845C>A	A1580S	1580	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	3%
38595845C>T	A1580T	1580	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	2%
38595844G>A	A1580V	1580	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	3%
38595841G>T	A1581D	1581	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	4%
38595841G>C	A1581G	1581	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	4%
38595842C>G	A1581P	1581	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	4%
38595842C>A	A1581S	1581	1	0	0	0	1	NA	Mild_Hotspot	16%	Non_Hotspot	1%
38595842C>T	A1581T	1581	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	4%
38595841G>A	A1581V	1581	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	4%
38592980G>T	A1628D	1628	0	0	0	0	0	NA	Mild_Hotspot	25%	Mild_Hotspot	18%
38592980G>C	A1628G	1628	0	0	0	0	0	NA	Mild_Hotspot	25%	Mild_Hotspot	18%
38592981C>G	A1628P	1628	0	0	0	0	0	NA	Mild_Hotspot	25%	Mild_Hotspot	18%
38592981C>A	A1628S	1628	0	0	0	0	0	NA	Mild_Hotspot	25%	Mild_Hotspot	18%
38592981C>T	A1628T	1628	0	0	0	0	0	NA	Mild_Hotspot	25%	Mild_Hotspot	18%
38592980G>A	A1628V	1628	0	0	0	0	0	NA	Mild_Hotspot	24%	Mild_Hotspot	18%
38592944G>T	A1640D	1640	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	11%
38592944G>C	A1640G	1640	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	11%
38592945C>G	A1640P	1640	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	11%
38592945C>A	A1640S	1640	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	11%
38592945C>T	A1640T	1640	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	11%
38592944G>A	A1640V	1640	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	11%
38592917G>T	A1649D	1649	0	0	0	0	0	NA	Hotspot	46%	Mild_Hotspot	22%
38592917G>C	A1649G	1649	0	0	0	0	0	NA	Hotspot	46%	Mild_Hotspot	22%
38592918C>G	A1649P	1649	0	0	0	0	0	NA	Hotspot	46%	Mild_Hotspot	22%
38592918C>A	A1649S	1649	0	0	0	0	0	NA	Hotspot	45%	Mild_Hotspot	22%
38592918C>T	A1649T	1649	0	0	0	0	0	NA	Hotspot	46%	Mild_Hotspot	22%
38592917G>A	A1649V	1649	1	0	1	0	0	NA	Hotspot	49%	Mild_Hotspot	19%
38592896G>T	A1656D	1656	0	0	0	0	0	NA	Hotspot	31%	Mild_Hotspot	27%
38592896G>C	A1656G	1656	0	0	0	0	0	NA	Hotspot	31%	Mild_Hotspot	27%
38592897C>G	A1656P	1656	0	0	0	0	0	NA	Hotspot	31%	Mild_Hotspot	27%
38592897C>A	A1656S	1656	0	0	0	0	0	NA	Hotspot	30%	Mild_Hotspot	27%
38592897C>T	A1656T	1656	0	0	0	0	0	NA	Hotspot	31%	Mild_Hotspot	27%
38592896G>A	A1656V	1656	0	0	0	3	0	NA	Hotspot	31%	Mild_Hotspot	25%
38662448G>T	A166D	166	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38662448G>C	A166G	166	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38662449C>G	A166P	166	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38662449C>A	A166S	166	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	3%
38662449C>T	A166T	166	70	0	0	0	70	Normal	Non_Hotspot	2%	Non_Hotspot	1%
38662448G>A	A166V	166	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	3%
38592833G>T	A1677D	1677	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38592833G>C	A1677G	1677	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38592834C>G	A1677P	1677	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38592834C>A	A1677S	1677	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38592834C>T	A1677T	1677	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38592833G>A	A1677V	1677	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38592824G>T	A1680D	1680	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	5%
38592824G>C	A1680G	1680	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	5%
38592825C>G	A1680P	1680	1	0	0	0	1	NA	Non_Hotspot	10%	Non_Hotspot	5%
38592825C>A	A1680S	1680	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	5%
38592825C>T	A1680T	1680	18	1	4	2	13	Normal	Non_Hotspot	17%	Non_Hotspot	5%
38592824G>A	A1680V	1680	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	5%
38592806G>T	A1686D	1686	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	2%
38592806G>C	A1686G	1686	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	2%
38592807C>G	A1686P	1686	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	3%
38592807C>A	A1686S	1686	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	2%
38592807C>T	A1686T	1686	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	2%
38592806G>A	A1686V	1686	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	3%
38592770G>T	A1698D	1698	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	4%
38592770G>C	A1698G	1698	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	2%
38592771C>G	A1698P	1698	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	4%
38592771C>A	A1698S	1698	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	3%
38592771C>T	A1698T	1698	4	0	1	0	3	NA	Mild_Hotspot	22%	Non_Hotspot	2%
38592770G>A	A1698V	1698	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	4%
38592731G>T	A1711D	1711	0	0	0	0	0	NA	Hotspot	44%	Non_Hotspot	6%
38592731G>C	A1711G	1711	0	0	0	0	0	NA	Hotspot	44%	Non_Hotspot	5%
38592732C>G	A1711P	1711	0	0	0	0	0	NA	Hotspot	44%	Non_Hotspot	6%
38592732C>A	A1711S	1711	0	0	0	0	0	NA	Hotspot	44%	Non_Hotspot	5%
38592732C>T	A1711T	1711	0	0	0	0	0	NA	Hotspot	44%	Non_Hotspot	6%
38592731G>A	A1711V	1711	0	0	0	0	0	NA	Hotspot	44%	Non_Hotspot	5%
38592626G>T	A1746D	1746	0	0	0	0	0	NA	Mild_Hotspot	13%	Mild_Hotspot	20%
38592626G>C	A1746G	1746	0	0	0	0	0	NA	Mild_Hotspot	12%	Mild_Hotspot	20%
38592627C>G	A1746P	1746	0	0	0	0	0	NA	Mild_Hotspot	11%	Mild_Hotspot	20%
38592627C>A	A1746S	1746	0	0	0	0	0	NA	Mild_Hotspot	11%	Mild_Hotspot	19%
38592627C>T	A1746T	1746	5	3	0	0	2	NA	Mild_Hotspot	9%	Mild_Hotspot	28%
38592626G>A	A1746V	1746	15	0	0	0	15	Normal	Mild_Hotspot	7%	Mild_Hotspot	12%
38592557G>T	A1769D	1769	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	39%
38592557G>C	A1769G	1769	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	39%
38592558C>G	A1769P	1769	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	39%
38592558C>A	A1769S	1769	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	39%
38592558C>T	A1769T	1769	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	39%
38592557G>A	A1769V	1769	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	39%
38592530G>T	A1778D	1778	0	0	0	0	0	NA	Non_Hotspot	12%	Hotspot	38%
38592530G>C	A1778G	1778	0	0	0	0	0	NA	Non_Hotspot	12%	Hotspot	37%
38592531C>G	A1778P	1778	0	0	0	0	0	NA	Non_Hotspot	12%	Hotspot	38%
38592531C>A	A1778S	1778	0	0	0	0	0	NA	Non_Hotspot	12%	Hotspot	37%
38592531C>T	A1778T	1778	0	0	0	0	0	NA	Non_Hotspot	12%	Hotspot	38%
38592530G>A	A1778V	1778	0	0	0	0	0	NA	Non_Hotspot	12%	Hotspot	37%
38662412G>T	A178D	178	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	4%
38662412G>C	A178G	178	1	0	1	0	0	Normal	Hotspot	51%	Non_Hotspot	3%
38662413C>G	A178P	178	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	4%
38662413C>A	A178S	178	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	4%
38662413C>T	A178T	178	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	4%
38662412G>A	A178V	178	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	4%
38592449G>T	A1805D	1805	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	22%
38592449G>C	A1805G	1805	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	21%
38592450C>G	A1805P	1805	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	22%
38592450C>A	A1805S	1805	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	22%
38592450C>T	A1805T	1805	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	22%
38592449G>A	A1805V	1805	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	22%
38592410G>T	A1818D	1818	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	7%
38592410G>C	A1818G	1818	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	7%
38592411C>G	A1818P	1818	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	7%
38592411C>A	A1818S	1818	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	7%
38592411C>T	A1818T	1818	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	7%
38592410G>A	A1818V	1818	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	7%
38592404G>T	A1820D	1820	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	6%
38592404G>C	A1820G	1820	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	6%
38592405C>G	A1820P	1820	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	6%
38592405C>A	A1820S	1820	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38592405C>T	A1820T	1820	5	0	0	0	5	NA	Non_Hotspot	1%	Non_Hotspot	5%
38592404G>A	A1820V	1820	1	0	0	0	1	NA	Non_Hotspot	6%	Non_Hotspot	6%
38592380G>T	A1828D	1828	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	7%
38592380G>C	A1828G	1828	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	6%
38592381C>G	A1828P	1828	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	5%
38592381C>A	A1828S	1828	1	0	0	0	1	NA	Non_Hotspot	4%	Non_Hotspot	2%
38592381C>T	A1828T	1828	11	0	0	0	11	NA	Non_Hotspot	3%	Non_Hotspot	3%
38592380G>A	A1828V	1828	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	7%
38592296G>T	A1856D	1856	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	7%
38592296G>C	A1856G	1856	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	7%
38592297C>G	A1856P	1856	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	7%
38592297C>A	A1856S	1856	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	7%
38592297C>T	A1856T	1856	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	7%
38592296G>A	A1856V	1856	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	7%
38662391G>T	A185E	185	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38662391G>C	A185G	185	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38662392C>G	A185P	185	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38662392C>A	A185S	185	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38662392C>T	A185T	185	123	3	0	0	120	Mild_LOF	Mild_Hotspot	2%	Non_Hotspot	3%
38662391G>A	A185V	185	5	0	1	0	4	NA	Mild_Hotspot	17%	Non_Hotspot	3%
38592254G>T	A1870D	1870	0	0	0	1	0	Normal	Mild_Hotspot	16%	Mild_Hotspot	19%
38592254G>C	A1870G	1870	0	0	0	0	0	NA	Mild_Hotspot	16%	Mild_Hotspot	18%
38592255C>G	A1870P	1870	0	0	0	0	0	NA	Mild_Hotspot	16%	Mild_Hotspot	18%
38592255C>A	A1870S	1870	0	0	0	0	0	NA	Mild_Hotspot	15%	Mild_Hotspot	17%
38592255C>T	A1870T	1870	3	1	0	0	2	NA	Mild_Hotspot	13%	Mild_Hotspot	19%
38592254G>A	A1870V	1870	0	0	0	0	0	NA	Mild_Hotspot	16%	Mild_Hotspot	18%
38592221G>T	A1881E	1881	0	0	0	0	0	NA	Mild_Hotspot	24%	Non_Hotspot	4%
38592221G>C	A1881G	1881	0	0	0	0	0	NA	Mild_Hotspot	23%	Non_Hotspot	4%
38592222C>G	A1881P	1881	0	0	0	0	0	NA	Mild_Hotspot	24%	Non_Hotspot	4%
38592222C>A	A1881S	1881	0	0	0	0	0	NA	Mild_Hotspot	23%	Non_Hotspot	3%
38592222C>T	A1881T	1881	0	0	0	0	0	NA	Mild_Hotspot	23%	Non_Hotspot	4%
38592221G>A	A1881V	1881	0	0	0	0	0	NA	Mild_Hotspot	23%	Non_Hotspot	4%
38592218G>T	A1882D	1882	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	4%
38592218G>C	A1882G	1882	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	4%
38592219C>G	A1882P	1882	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	4%
38592219C>A	A1882S	1882	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	3%
38592219C>T	A1882T	1882	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	2%
38592218G>A	A1882V	1882	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	3%
38592149G>T	A1905D	1905	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	7%
38592149G>C	A1905G	1905	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	7%
38592150C>G	A1905P	1905	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	7%
38592150C>A	A1905S	1905	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	7%
38592150C>T	A1905T	1905	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	7%
38592149G>A	A1905V	1905	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	7%
38592131G>T	A1911D	1911	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	11%
38592131G>C	A1911G	1911	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	11%
38592132C>G	A1911P	1911	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	11%
38592132C>A	A1911S	1911	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	11%
38592132C>T	A1911T	1911	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	11%
38592131G>A	A1911V	1911	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	11%
38592092G>T	A1924D	1924	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	4%
38592092G>C	A1924G	1924	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	4%
38592093C>G	A1924P	1924	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	4%
38592093C>A	A1924S	1924	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38592093C>T	A1924T	1924	17	0	1	2	16	NA	Mild_Hotspot	11%	Non_Hotspot	0%
38592092G>A	A1924V	1924	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38592068G>T	A1932E	1932	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38592068G>C	A1932G	1932	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38592069C>G	A1932P	1932	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38592069C>A	A1932S	1932	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38592069C>T	A1932T	1932	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38592068G>A	A1932V	1932	11	0	0	0	11	NA	Non_Hotspot	2%	Non_Hotspot	2%
38592041G>T	A1941D	1941	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38592041G>C	A1941G	1941	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38592042C>G	A1941P	1941	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38592042C>A	A1941S	1941	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38592042C>T	A1941T	1941	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38592041G>A	A1941V	1941	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38592017G>T	A1949D	1949	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	25%
38592017G>C	A1949G	1949	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	25%
38592018C>G	A1949P	1949	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	25%
38592018C>A	A1949S	1949	1	1	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	28%
38592018C>T	A1949T	1949	7	0	0	0	7	NA	Non_Hotspot	6%	Mild_Hotspot	17%
38592017G>A	A1949V	1949	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	25%
38591915G>T	A1983D	1983	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	8%
38591915G>C	A1983G	1983	4	1	0	0	3	NA	Non_Hotspot	2%	Non_Hotspot	11%
38591916C>G	A1983P	1983	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	7%
38591916C>A	A1983S	1983	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	7%
38591916C>T	A1983T	1983	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	7%
38591915G>A	A1983V	1983	1	0	0	0	1	NA	Non_Hotspot	6%	Non_Hotspot	9%
38591858G>T	A2002D	2002	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	3%
38591858G>C	A2002G	2002	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	3%
38591859C>G	A2002P	2002	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	3%
38591859C>A	A2002S	2002	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	3%
38591859C>T	A2002T	2002	6	0	0	0	6	NA	Non_Hotspot	6%	Non_Hotspot	4%
38591858G>A	A2002V	2002	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	3%
38662334G>T	A204E	204	0	0	0	0	0	NA	Hotspot	33%	Non_Hotspot	4%
38662334G>C	A204G	204	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	4%
38662335C>G	A204P	204	0	0	0	0	0	NA	Hotspot	33%	Non_Hotspot	5%
38662335C>A	A204S	204	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	4%
38662335C>T	A204T	204	1	0	0	0	1	NA	Hotspot	31%	Non_Hotspot	3%
38662334G>A	A204V	204	1	0	1	0	0	NA	Hotspot	38%	Non_Hotspot	1%
38655287G>T	A217D	217	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	9%
38655287G>C	A217G	217	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	9%
38655288C>G	A217P	217	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	9%
38655288C>A	A217S	217	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	9%
38655288C>T	A217T	217	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	9%
38655287G>A	A217V	217	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	9%
38655260G>T	A226D	226	0	0	0	1	0	LOF	Mild_Hotspot	17%	Non_Hotspot	8%
38655260G>C	A226G	226	1	0	0	0	1	NA	Mild_Hotspot	13%	Non_Hotspot	6%
38655261C>G	A226P	226	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	9%
38655261C>A	A226S	226	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	9%
38655261C>T	A226T	226	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	9%
38655260G>A	A226V	226	36	0	4	1	32	Partial_LOF	Mild_Hotspot	12%	Non_Hotspot	3%
38674734G>T	A22E	22	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38674734G>C	A22G	22	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38674735C>G	A22P	22	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38674735C>A	A22S	22	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38674735C>T	A22T	22	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38674734G>A	A22V	22	2	0	0	0	2	NA	Non_Hotspot	3%	Non_Hotspot	6%
38674731G>T	A23D	23	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38674731G>C	A23G	23	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38674732C>G	A23P	23	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38674732C>A	A23S	23	1	0	0	0	1	NA	Non_Hotspot	4%	Non_Hotspot	5%
38674732C>T	A23T	23	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38674731G>A	A23V	23	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38651434G>T	A242D	242	1	1	0	0	0	NA	Non_Hotspot	8%	Hotspot	59%
38651434G>C	A242G	242	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	57%
38651435C>G	A242P	242	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	57%
38651435C>A	A242S	242	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	57%
38651435C>T	A242T	242	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	57%
38651434G>A	A242V	242	0	0	0	0	0	NA	Non_Hotspot	9%	Hotspot	57%
38651407G>T	A251D	251	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	23%
38651407G>C	A251G	251	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	22%
38651408C>G	A251P	251	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	22%
38651408C>A	A251S	251	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	21%
38651408C>T	A251T	251	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	22%
38651407G>A	A251V	251	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	22%
38651365G>T	A265D	265	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	7%
38651365G>C	A265G	265	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	7%
38651366C>G	A265P	265	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	7%
38651366C>A	A265S	265	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	7%
38651366C>T	A265T	265	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	7%
38651365G>A	A265V	265	1	0	0	0	1	NA	Non_Hotspot	8%	Non_Hotspot	4%
38651302G>T	A286E	286	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38651302G>C	A286G	286	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	2%
38651303C>G	A286P	286	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	2%
38651303C>A	A286S	286	80	0	0	0	80	Normal	Non_Hotspot	1%	Non_Hotspot	1%
38651303C>T	A286T	286	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	2%
38651302G>A	A286V	286	2	0	0	0	2	NA	Non_Hotspot	6%	Non_Hotspot	2%
38651272G>T	A296D	296	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38651272G>C	A296G	296	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38651273C>G	A296P	296	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38651273C>A	A296S	296	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38651273C>T	A296T	296	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38651272G>A	A296V	296	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38674713G>T	A29E	29	1	0	0	0	1	NA	Non_Hotspot	3%	Non_Hotspot	9%
38674713G>C	A29G	29	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	7%
38674714C>G	A29P	29	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	7%
38674714C>A	A29S	29	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	7%
38674714C>T	A29T	29	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	7%
38674713G>A	A29V	29	28	1	0	0	27	NA	Non_Hotspot	1%	Non_Hotspot	7%
38674794G>T	A2E	2	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	7%
38674794G>C	A2G	2	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	7%
38674795C>G	A2P	2	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	7%
38674795C>A	A2S	2	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	7%
38674795C>T	A2T	2	5	0	1	0	4	NA	Mild_Hotspot	20%	Non_Hotspot	5%
38674794G>A	A2V	2	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	7%
38649645G>T	A332D	332	0	0	0	0	0	NA	Mild_Hotspot	17%	Mild_Hotspot	19%
38649645G>C	A332G	332	0	0	0	0	0	NA	Mild_Hotspot	16%	Mild_Hotspot	19%
38649646C>G	A332P	332	0	0	0	0	0	NA	Mild_Hotspot	16%	Mild_Hotspot	19%
38649646C>A	A332S	332	0	0	0	0	0	NA	Mild_Hotspot	15%	Mild_Hotspot	18%
38649646C>T	A332T	332	3	1	0	0	2	NA	Mild_Hotspot	13%	Mild_Hotspot	19%
38649645G>A	A332V	332	0	0	0	0	0	NA	Mild_Hotspot	16%	Mild_Hotspot	19%
38674701G>T	A33D	33	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	7%
38674701G>C	A33G	33	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	7%
38674702C>G	A33P	33	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	7%
38674702C>A	A33S	33	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	7%
38674702C>T	A33T	33	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	7%
38674701G>A	A33V	33	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	7%
38648269G>T	A344E	344	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	7%
38648269G>C	A344G	344	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	6%
38648270C>G	A344P	344	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	7%
38648270C>A	A344S	344	1	0	0	0	1	NA	Mild_Hotspot	14%	Non_Hotspot	9%
38648270C>T	A344T	344	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	7%
38648269G>A	A344V	344	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	6%
38648224G>T	A359D	359	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	6%
38648224G>C	A359G	359	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	4%
38648225C>G	A359P	359	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	5%
38648225C>A	A359S	359	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	4%
38648225C>T	A359T	359	1	0	0	0	1	NA	Mild_Hotspot	14%	Non_Hotspot	5%
38648224G>A	A359V	359	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	5%
38648218G>T	A361D	361	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	9%
38648218G>C	A361G	361	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	9%
38648219C>G	A361P	361	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	9%
38648219C>A	A361S	361	0	0	0	0	0	NA	Hotspot	31%	Non_Hotspot	9%
38648219C>T	A361T	361	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	9%
38648218G>A	A361V	361	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	9%
38648209G>T	A364E	364	0	0	0	0	0	NA	Hotspot	42%	Mild_Hotspot	12%
38648209G>C	A364G	364	0	0	0	0	0	NA	Hotspot	42%	Mild_Hotspot	11%
38648210C>G	A364P	364	0	0	0	0	0	NA	Hotspot	42%	Mild_Hotspot	12%
38648210C>A	A364S	364	0	0	0	0	0	NA	Hotspot	40%	Mild_Hotspot	10%
38648210C>T	A364T	364	0	0	0	0	0	NA	Hotspot	41%	Mild_Hotspot	11%
38648209G>A	A364V	364	0	0	0	0	0	NA	Hotspot	42%	Mild_Hotspot	11%
38647626G>T	A385E	385	0	0	0	0	0	NA	Mild_Hotspot	28%	Non_Hotspot	8%
38647626G>C	A385G	385	0	0	0	0	0	NA	Mild_Hotspot	28%	Non_Hotspot	8%
38647627C>G	A385P	385	0	0	0	0	0	NA	Mild_Hotspot	28%	Non_Hotspot	8%
38647627C>A	A385S	385	0	0	0	0	0	NA	Mild_Hotspot	26%	Non_Hotspot	7%
38647627C>T	A385T	385	7	1	0	0	6	NA	Mild_Hotspot	20%	Non_Hotspot	11%
38647626G>A	A385V	385	0	0	0	0	0	NA	Mild_Hotspot	28%	Non_Hotspot	8%
38647551G>T	A410D	410	0	0	0	0	0	NA	Non_Hotspot	11%	Hotspot	31%
38647551G>C	A410G	410	0	0	0	0	0	NA	Non_Hotspot	11%	Hotspot	31%
38647552C>G	A410P	410	0	0	0	0	0	NA	Non_Hotspot	11%	Hotspot	31%
38647552C>A	A410S	410	0	0	0	0	0	NA	Non_Hotspot	11%	Hotspot	31%
38647552C>T	A410T	410	0	0	0	0	0	NA	Non_Hotspot	11%	Hotspot	31%
38647551G>A	A410V	410	1	0	0	0	1	NA	Non_Hotspot	9%	Hotspot	29%
0.>.	A410W	410	0	0	0	0	0	NA	Non_Hotspot	12%	Hotspot	31%
38647542G>T	A413E	413	1	1	0	0	0	NA	Non_Hotspot	13%	Hotspot	40%
38647542G>C	A413G	413	0	0	0	0	0	NA	Non_Hotspot	13%	Hotspot	38%
38647543C>G	A413P	413	0	0	0	0	0	NA	Non_Hotspot	12%	Hotspot	38%
38647543C>A	A413S	413	0	0	0	0	0	NA	Non_Hotspot	12%	Hotspot	38%
38647543C>T	A413T	413	7	3	0	0	4	NA	Non_Hotspot	8%	Hotspot	39%
38647542G>A	A413V	413	0	0	0	0	0	NA	Non_Hotspot	12%	Hotspot	38%
38647536G>T	A415D	415	0	0	0	0	0	NA	Mild_Hotspot	13%	Mild_Hotspot	13%
38647536G>C	A415G	415	0	0	0	0	0	NA	Mild_Hotspot	12%	Mild_Hotspot	13%
38647537C>G	A415P	415	0	0	0	0	0	NA	Mild_Hotspot	13%	Mild_Hotspot	13%
38647537C>A	A415S	415	0	0	0	0	0	NA	Mild_Hotspot	11%	Mild_Hotspot	12%
38647537C>T	A415T	415	1	0	0	0	1	NA	Mild_Hotspot	10%	Mild_Hotspot	13%
38647536G>A	A415V	415	0	0	0	0	0	NA	Mild_Hotspot	12%	Mild_Hotspot	13%
38647515G>T	A422D	422	0	0	0	0	0	NA	Non_Hotspot	10%	Mild_Hotspot	17%
38647515G>C	A422G	422	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	17%
38647516C>G	A422P	422	0	0	0	0	0	NA	Non_Hotspot	10%	Mild_Hotspot	17%
38647516C>A	A422S	422	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	17%
38647516C>T	A422T	422	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	17%
38647515G>A	A422V	422	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	17%
38647506G>T	A425D	425	0	0	0	0	0	NA	Non_Hotspot	5%	Hotspot	29%
38647506G>C	A425G	425	0	0	0	0	0	NA	Non_Hotspot	5%	Hotspot	28%
38647507C>G	A425P	425	1	0	0	0	1	NA	Non_Hotspot	5%	Hotspot	30%
38647507C>A	A425S	425	0	0	0	0	0	NA	Non_Hotspot	6%	Hotspot	29%
38647507C>T	A425T	425	1	1	0	0	0	NA	Non_Hotspot	3%	Hotspot	35%
38647506G>A	A425V	425	0	0	0	0	0	NA	Non_Hotspot	5%	Hotspot	28%
38647470G>T	A437D	437	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	3%
38647470G>C	A437G	437	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	3%
38647471C>G	A437P	437	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	3%
38647471C>A	A437S	437	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	3%
38647471C>T	A437T	437	0	0	0	0	0	NA	Mild_Hotspot	21%	Non_Hotspot	3%
38647470G>A	A437V	437	1	0	0	0	1	NA	Mild_Hotspot	19%	Non_Hotspot	4%
38646398G>T	A447D	447	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	3%
38646398G>C	A447G	447	20	0	0	0	20	NA	Non_Hotspot	3%	Non_Hotspot	3%
38646399C>G	A447P	447	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	3%
38646399C>A	A447S	447	1	0	0	0	1	NA	Non_Hotspot	7%	Non_Hotspot	3%
38646399C>T	A447T	447	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38646398G>A	A447V	447	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38646338G>T	A467D	467	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38646338G>C	A467G	467	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38646339C>G	A467P	467	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38646339C>A	A467S	467	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	3%
38646339C>T	A467T	467	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38646338G>A	A467V	467	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38646224G>T	A505E	505	1	0	0	0	1	NA	Non_Hotspot	8%	Mild_Hotspot	7%
38646224G>C	A505G	505	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	10%
38646225C>G	A505P	505	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	10%
38646225C>A	A505S	505	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	9%
38646225C>T	A505T	505	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	10%
38646224G>A	A505V	505	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	9%
38674647G>T	A51D	51	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	6%
38674647G>C	A51G	51	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	6%
38674648C>G	A51P	51	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	6%
38674648C>A	A51S	51	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	6%
38674648C>T	A51T	51	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	6%
38674647G>A	A51V	51	3	0	0	0	3	NA	Non_Hotspot	1%	Non_Hotspot	11%
38645471G>T	A541E	541	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	6%
38645471G>C	A541G	541	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	6%
38645472C>G	A541P	541	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	6%
38645472C>A	A541S	541	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	5%
38645472C>T	A541T	541	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	6%
38645471G>A	A541V	541	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	6%
38645462G>T	A544E	544	0	0	0	0	0	NA	Hotspot	55%	Non_Hotspot	5%
38645462G>C	A544G	544	0	0	0	0	0	NA	Hotspot	55%	Non_Hotspot	4%
38645463C>G	A544P	544	0	0	0	0	0	NA	Hotspot	55%	Non_Hotspot	4%
38645463C>A	A544S	544	0	0	0	0	0	NA	Hotspot	55%	Non_Hotspot	5%
38645463C>T	A544T	544	0	0	0	0	0	NA	Hotspot	55%	Non_Hotspot	4%
38645462G>A	A544V	544	0	0	0	0	0	NA	Hotspot	55%	Non_Hotspot	4%
38645441G>T	A551E	551	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	6%
38645441G>C	A551G	551	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	2%
38645442C>G	A551P	551	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	2%
38645442C>A	A551S	551	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	2%
38645442C>T	A551T	551	3	0	2	0	1	Partial_LOF	Mild_Hotspot	28%	Non_Hotspot	3%
38645441G>A	A551V	551	12	0	0	0	12	NA	Mild_Hotspot	12%	Non_Hotspot	3%
0.>.	A572D	572	1465	5	1	9	1459	Normal	Non_Hotspot	0%	Mild_Hotspot	0%
0.>.	A572F	572	2	2	0	1	0	Normal	Non_Hotspot	5%	Mild_Hotspot	22%
38645378G>C	A572G	572	0	0	0	0	0	NA	Non_Hotspot	3%	Mild_Hotspot	15%
38645379C>G	A572P	572	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	16%
38645379C>A	A572S	572	68	1	0	0	67	NA	Non_Hotspot	1%	Mild_Hotspot	4%
38645379C>T	A572T	572	0	0	0	0	0	NA	Non_Hotspot	3%	Mild_Hotspot	15%
38645378G>A	A572V	572	68	1	0	0	67	NA	Non_Hotspot	1%	Mild_Hotspot	4%
38645348G>T	A582D	582	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	5%
38645348G>C	A582G	582	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	5%
38645349C>G	A582P	582	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	5%
38645349C>A	A582S	582	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	5%
38645349C>T	A582T	582	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	5%
38645348G>A	A582V	582	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	5%
38645336G>T	A586D	586	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	17%
38645336G>C	A586G	586	1	0	0	0	1	NA	Non_Hotspot	7%	Mild_Hotspot	15%
38645337C>G	A586P	586	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	17%
38645337C>A	A586S	586	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	16%
38645337C>T	A586T	586	5	0	1	0	4	NA	Non_Hotspot	12%	Mild_Hotspot	11%
38645336G>A	A586V	586	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	16%
38645276G>T	A606E	606	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	5%
38645276G>C	A606G	606	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	4%
38645277C>G	A606P	606	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38645277C>A	A606S	606	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38645277C>T	A606T	606	1	0	0	0	1	NA	Non_Hotspot	1%	Non_Hotspot	4%
38645276G>A	A606V	606	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	5%
38674620G>T	A60D	60	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38674620G>C	A60G	60	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38674621C>G	A60P	60	2	0	0	0	2	NA	Non_Hotspot	6%	Non_Hotspot	5%
38674621C>A	A60S	60	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38674621C>T	A60T	60	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38674620G>A	A60V	60	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38645261G>T	A611D	611	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	10%
38645261G>C	A611G	611	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	9%
38645262C>G	A611P	611	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	10%
38645262C>A	A611S	611	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	9%
38645262C>T	A611T	611	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	9%
38645261G>A	A611V	611	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	9%
38640492G>T	A647D	647	2	0	2	0	0	Normal	Mild_Hotspot	30%	Non_Hotspot	1%
38640492G>C	A647G	647	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	3%
38640493C>G	A647P	647	0	0	0	0	0	NA	Mild_Hotspot	21%	Non_Hotspot	4%
38640493C>A	A647S	647	5	0	0	0	5	NA	Mild_Hotspot	16%	Non_Hotspot	2%
38640493C>T	A647T	647	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	3%
38640492G>A	A647V	647	3	0	0	0	3	NA	Mild_Hotspot	19%	Non_Hotspot	1%
38640459G>T	A658E	658	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38640459G>C	A658G	658	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38640460C>G	A658P	658	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38640460C>A	A658S	658	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38640460C>T	A658T	658	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38640459G>A	A658V	658	1	0	0	0	1	NA	Non_Hotspot	2%	Non_Hotspot	3%
38640447G>T	A662D	662	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38640447G>C	A662G	662	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38640448C>G	A662P	662	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38640448C>A	A662S	662	6	0	0	1	6	NA	Non_Hotspot	6%	Non_Hotspot	1%
38640448C>T	A662T	662	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38640447G>A	A662V	662	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38640438G>T	A665E	665	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38640438G>C	A665G	665	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38640439C>G	A665P	665	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38640439C>A	A665S	665	15	1	0	0	14	NA	Non_Hotspot	2%	Non_Hotspot	5%
38640439C>T	A665T	665	17	0	0	1	17	NA	Non_Hotspot	2%	Non_Hotspot	3%
38640438G>A	A665V	665	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38640417G>T	A672E	672	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	9%
38640417G>C	A672G	672	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	8%
38640418C>G	A672P	672	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	9%
38640418C>A	A672S	672	1	0	0	0	1	NA	Non_Hotspot	2%	Non_Hotspot	7%
38640418C>T	A672T	672	201	1	0	0	200	NA	Non_Hotspot	0%	Non_Hotspot	1%
38640417G>A	A672V	672	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	8%
38639410G>T	A691D	691	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	6%
38639410G>C	A691G	691	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	6%
38639411C>G	A691P	691	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	6%
38639411C>A	A691S	691	2	0	0	0	2	NA	Non_Hotspot	4%	Non_Hotspot	3%
38639411C>T	A691T	691	23	1	0	0	22	NA	Non_Hotspot	2%	Non_Hotspot	3%
38639410G>A	A691V	691	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	6%
38639278G>T	A735E	735	2	0	2	0	0	LOF	Hotspot	53%	Non_Hotspot	2%
38639278G>C	A735G	735	0	0	0	0	0	NA	Hotspot	46%	Non_Hotspot	9%
38639279C>G	A735P	735	0	0	0	0	0	NA	Hotspot	46%	Non_Hotspot	9%
38639279C>A	A735S	735	0	0	0	0	0	NA	Hotspot	45%	Non_Hotspot	9%
38639279C>T	A735T	735	4	0	3	0	1	Mild_LOF	Hotspot	50%	Non_Hotspot	3%
38639278G>A	A735V	735	8	0	5	2	3	Normal	Hotspot	49%	Non_Hotspot	1%
38629042G>T	A762E	762	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	5%
38629042G>C	A762G	762	0	0	0	0	0	NA	Mild_Hotspot	21%	Non_Hotspot	4%
38629043C>G	A762P	762	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	5%
38629043C>A	A762S	762	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	4%
38629043C>T	A762T	762	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	4%
38629042G>A	A762V	762	0	0	0	0	0	NA	Mild_Hotspot	21%	Non_Hotspot	4%
38629018G>T	A770D	770	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	29%
38629018G>C	A770G	770	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	29%
38629019C>G	A770P	770	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	29%
38629019C>A	A770S	770	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	29%
38629019C>T	A770T	770	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	29%
38629018G>A	A770V	770	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	29%
38627513G>T	A819D	819	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	7%
38627513G>C	A819G	819	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	7%
38627514C>G	A819P	819	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	7%
38627514C>A	A819S	819	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	7%
38627514C>T	A819T	819	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	7%
38627513G>A	A819V	819	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	7%
38627456G>T	A838E	838	0	0	0	0	0	NA	Mild_Hotspot	27%	Non_Hotspot	10%
38627456G>C	A838G	838	0	0	0	0	0	NA	Mild_Hotspot	27%	Non_Hotspot	10%
38627457C>G	A838P	838	0	0	0	0	0	NA	Mild_Hotspot	28%	Non_Hotspot	10%
38627457C>A	A838S	838	0	0	0	0	0	NA	Mild_Hotspot	27%	Non_Hotspot	10%
38627457C>T	A838T	838	0	0	0	0	0	NA	Mild_Hotspot	27%	Non_Hotspot	10%
38627456G>A	A838V	838	0	0	0	0	0	NA	Mild_Hotspot	27%	Non_Hotspot	10%
38627429G>T	A847D	847	0	0	0	0	0	NA	Mild_Hotspot	30%	Mild_Hotspot	17%
38627429G>C	A847G	847	0	0	0	0	0	NA	Mild_Hotspot	30%	Mild_Hotspot	17%
38627430C>G	A847P	847	0	0	0	0	0	NA	Mild_Hotspot	30%	Mild_Hotspot	17%
38627430C>A	A847S	847	0	0	0	0	0	NA	Mild_Hotspot	30%	Mild_Hotspot	17%
38627430C>T	A847T	847	0	0	0	0	0	NA	Mild_Hotspot	30%	Mild_Hotspot	17%
38627429G>A	A847V	847	0	0	0	0	0	NA	Mild_Hotspot	29%	Mild_Hotspot	17%
38627408G>T	A854D	854	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	5%
38627408G>C	A854G	854	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	5%
38627409C>G	A854P	854	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	5%
38627409C>A	A854S	854	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	5%
38627409C>T	A854T	854	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	5%
38627408G>A	A854V	854	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	5%
38627309G>T	A887D	887	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	4%
38627309G>C	A887G	887	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	4%
38627310C>G	A887P	887	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	4%
38627310C>A	A887S	887	0	0	0	0	0	NA	Hotspot	37%	Non_Hotspot	3%
38627310C>T	A887T	887	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	4%
38627309G>A	A887V	887	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	4%
38622843G>T	A936D	936	0	0	0	0	0	NA	Hotspot	40%	Mild_Hotspot	11%
38622843G>C	A936G	936	0	0	0	0	0	NA	Hotspot	40%	Mild_Hotspot	11%
38622844C>G	A936P	936	0	0	0	0	0	NA	Hotspot	40%	Mild_Hotspot	12%
38622844C>A	A936S	936	0	0	0	0	0	NA	Hotspot	40%	Mild_Hotspot	11%
38622844C>T	A936T	936	0	0	0	0	0	NA	Hotspot	40%	Mild_Hotspot	12%
38622843G>A	A936V	936	0	0	0	0	0	NA	Hotspot	40%	Mild_Hotspot	11%
38622819G>T	A944E	944	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	15%
38622819G>C	A944G	944	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	15%
38622820C>G	A944P	944	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	15%
38622820C>A	A944S	944	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	14%
38622820C>T	A944T	944	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	15%
38622819G>A	A944V	944	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	15%
38622804G>T	A949D	949	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	8%
38622804G>C	A949G	949	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	7%
38622805C>G	A949P	949	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	7%
38622805C>A	A949S	949	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	7%
38622805C>T	A949T	949	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	7%
38622804G>A	A949V	949	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	7%
38622765G>T	A962D	962	0	0	0	0	0	NA	Non_Hotspot	12%	Mild_Hotspot	22%
38622765G>C	A962G	962	0	0	0	0	0	NA	Non_Hotspot	11%	Mild_Hotspot	22%
38622766C>G	A962P	962	0	0	0	0	0	NA	Non_Hotspot	11%	Mild_Hotspot	22%
38622766C>A	A962S	962	0	0	0	0	0	NA	Non_Hotspot	11%	Mild_Hotspot	21%
38622766C>T	A962T	962	0	0	0	0	0	NA	Non_Hotspot	11%	Mild_Hotspot	22%
38622765G>A	A962V	962	0	0	0	0	0	NA	Non_Hotspot	11%	Mild_Hotspot	22%
38622759G>T	A964D	964	0	0	0	0	0	NA	Mild_Hotspot	11%	Mild_Hotspot	13%
38622759G>C	A964G	964	1	0	0	0	1	NA	Mild_Hotspot	9%	Mild_Hotspot	11%
38622760C>G	A964P	964	0	0	0	0	0	NA	Mild_Hotspot	12%	Mild_Hotspot	13%
38622760C>A	A964S	964	0	0	0	0	0	NA	Mild_Hotspot	11%	Mild_Hotspot	13%
38622760C>T	A964T	964	0	0	0	0	0	NA	Mild_Hotspot	11%	Mild_Hotspot	13%
38622759G>A	A964V	964	0	0	0	0	0	NA	Mild_Hotspot	11%	Mild_Hotspot	13%
38622672G>T	A993E	993	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	11%
38622672G>C	A993G	993	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	10%
38622673C>G	A993P	993	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	11%
38622673C>A	A993S	993	1	0	0	0	1	NA	Non_Hotspot	4%	Mild_Hotspot	9%
38622673C>T	A993T	993	5	2	0	0	3	GOF	Non_Hotspot	0%	Mild_Hotspot	17%
38622672G>A	A993V	993	0	0	0	0	0	NA	Non_Hotspot	3%	Mild_Hotspot	10%
38622669G>T	A994D	994	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	6%
38622669G>C	A994G	994	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	5%
38622670C>G	A994P	994	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	5%
38622670C>A	A994S	994	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	4%
38622670C>T	A994T	994	1	0	0	0	1	NA	Non_Hotspot	4%	Non_Hotspot	5%
38622669G>A	A994V	994	1	0	0	0	1	NA	Non_Hotspot	4%	Non_Hotspot	4%
38622663G>T	A996D	996	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	6%
38622663G>C	A996G	996	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	6%
38622664C>G	A996P	996	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	6%
38622664C>A	A996S	996	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	6%
38622664C>T	A996T	996	1	0	0	0	1	NA	Non_Hotspot	4%	Non_Hotspot	5%
38622663G>A	A996V	996	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	6%
38622660G>T	A997D	997	10	0	0	1	10	NA	Non_Hotspot	7%	Mild_Hotspot	3%
38622660G>C	A997G	997	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	10%
38622661C>G	A997P	997	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	10%
38622661C>A	A997S	997	2	1	0	1	1	GOF	Non_Hotspot	6%	Mild_Hotspot	12%
38622661C>T	A997T	997	24	0	1	1	23	Partial_LOF	Non_Hotspot	7%	Mild_Hotspot	4%
38622660G>A	A997V	997	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	10%
38622639C>A	C1004F	1004	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38622640A>C	C1004G	1004	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	5%
38622640A>G	C1004R	1004	71	1	0	0	70	NA	Non_Hotspot	2%	Non_Hotspot	3%
38622640A>T	C1004S	1004	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38622639C>G	C1004S	1004	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38622638G>C	C1004W	1004	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38622639C>T	C1004Y	1004	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38622513C>A	C1046F	1046	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622514A>C	C1046G	1046	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38622514A>G	C1046R	1046	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622514A>T	C1046S	1046	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622513C>G	C1046S	1046	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622512A>C	C1046W	1046	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38622513C>T	C1046Y	1046	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38620832C>A	C1128F	1128	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620833A>C	C1128G	1128	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620833A>G	C1128R	1128	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620833A>T	C1128S	1128	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620832C>G	C1128S	1128	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620831G>C	C1128W	1128	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38620832C>T	C1128Y	1128	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38618256C>A	C1136F	1136	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38618257A>C	C1136G	1136	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38618257A>G	C1136R	1136	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38618257A>T	C1136S	1136	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38618256C>G	C1136S	1136	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38618255G>C	C1136W	1136	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38618256C>T	C1136Y	1136	1	0	0	0	1	NA	Non_Hotspot	10%	Non_Hotspot	4%
38618163C>A	C1167F	1167	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	12%
38618164A>C	C1167G	1167	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	12%
38618164A>G	C1167R	1167	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	12%
38618163C>G	C1167S	1167	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	12%
38618164A>T	C1167S	1167	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	12%
38618162G>C	C1167W	1167	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	12%
38618163C>T	C1167Y	1167	1	0	0	0	1	NA	Non_Hotspot	4%	Mild_Hotspot	17%
38616939C>A	C1172F	1172	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	6%
38616940A>C	C1172G	1172	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	6%
38616940A>G	C1172R	1172	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	6%
38616940A>T	C1172S	1172	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	6%
38616939C>G	C1172S	1172	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	6%
38616938A>C	C1172W	1172	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38616939C>T	C1172Y	1172	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	6%
38616927C>A	C1176F	1176	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38616928A>C	C1176G	1176	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38616928A>G	C1176R	1176	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38616928A>T	C1176S	1176	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38616927C>G	C1176S	1176	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38616926A>C	C1176W	1176	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38616927C>T	C1176Y	1176	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38616921C>A	C1178F	1178	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38616922A>C	C1178G	1178	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38616922A>G	C1178R	1178	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38616922A>T	C1178S	1178	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38616921C>G	C1178S	1178	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38616920G>C	C1178W	1178	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38616921C>T	C1178Y	1178	1	0	0	0	1	NA	Non_Hotspot	4%	Non_Hotspot	2%
38616918C>A	C1179F	1179	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38616919A>C	C1179G	1179	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38616919A>G	C1179R	1179	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	5%
38616919A>T	C1179S	1179	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	5%
38616918C>G	C1179S	1179	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38616917A>C	C1179W	1179	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38616918C>T	C1179Y	1179	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38616861C>A	C1198F	1198	0	0	0	0	0	NA	Mild_Hotspot	15%	Mild_Hotspot	26%
38616862A>C	C1198G	1198	0	0	0	0	0	NA	Mild_Hotspot	15%	Mild_Hotspot	26%
38616862A>G	C1198R	1198	0	0	0	0	0	NA	Mild_Hotspot	15%	Mild_Hotspot	26%
38616862A>T	C1198S	1198	0	0	0	0	0	NA	Mild_Hotspot	15%	Mild_Hotspot	26%
38616861C>G	C1198S	1198	0	0	0	0	0	NA	Mild_Hotspot	15%	Mild_Hotspot	26%
38616860G>C	C1198W	1198	0	0	0	0	0	NA	Mild_Hotspot	15%	Mild_Hotspot	26%
38616861C>T	C1198Y	1198	0	0	0	0	0	NA	Mild_Hotspot	15%	Mild_Hotspot	26%
38607925C>A	C1272F	1272	0	0	0	0	0	NA	Mild_Hotspot	28%	Non_Hotspot	7%
38607926A>C	C1272G	1272	0	0	0	0	0	NA	Mild_Hotspot	28%	Non_Hotspot	7%
38607926A>G	C1272R	1272	0	0	0	0	0	NA	Mild_Hotspot	28%	Non_Hotspot	7%
38607926A>T	C1272S	1272	0	0	0	0	0	NA	Mild_Hotspot	27%	Non_Hotspot	7%
38607925C>G	C1272S	1272	0	0	0	0	0	NA	Mild_Hotspot	27%	Non_Hotspot	7%
38607924G>C	C1272W	1272	0	0	0	0	0	NA	Mild_Hotspot	28%	Non_Hotspot	7%
38607925C>T	C1272Y	1272	0	0	0	0	0	NA	Mild_Hotspot	28%	Non_Hotspot	7%
38601861C>A	C1341F	1341	0	0	0	0	0	NA	Hotspot	32%	Mild_Hotspot	12%
38601862A>C	C1341G	1341	0	0	0	0	0	NA	Hotspot	32%	Mild_Hotspot	11%
38601862A>G	C1341R	1341	0	0	0	0	0	NA	Hotspot	32%	Mild_Hotspot	12%
38601862A>T	C1341S	1341	0	0	0	0	0	NA	Hotspot	32%	Mild_Hotspot	12%
38601861C>G	C1341S	1341	0	0	0	0	0	NA	Hotspot	32%	Mild_Hotspot	11%
38601860G>C	C1341W	1341	0	0	0	0	0	NA	Hotspot	31%	Mild_Hotspot	11%
38601861C>T	C1341Y	1341	0	0	0	0	0	NA	Hotspot	32%	Mild_Hotspot	12%
38601795C>A	C1363F	1363	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	4%
38601796A>C	C1363G	1363	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	4%
38601796A>G	C1363R	1363	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	4%
38601796A>T	C1363S	1363	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	4%
38601795C>G	C1363S	1363	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	4%
38601794G>C	C1363W	1363	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	4%
38601795C>T	C1363Y	1363	1	0	1	0	0	NA	Hotspot	40%	Non_Hotspot	8%
38601732C>A	C1384F	1384	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	4%
38601733A>C	C1384G	1384	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	4%
38601733A>G	C1384R	1384	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	4%
38601733A>T	C1384S	1384	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	4%
38601732C>G	C1384S	1384	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	4%
38601731A>C	C1384W	1384	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	4%
38601732C>T	C1384Y	1384	1	0	0	0	1	NA	Mild_Hotspot	12%	Non_Hotspot	8%
38663957C>A	C139F	139	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	3%
38663958A>C	C139G	139	0	0	0	0	0	NA	Hotspot	33%	Non_Hotspot	4%
38663958A>G	C139R	139	0	0	0	0	0	NA	Hotspot	33%	Non_Hotspot	4%
38663958A>T	C139S	139	0	0	0	0	0	NA	Hotspot	33%	Non_Hotspot	4%
38663957C>G	C139S	139	0	0	0	0	0	NA	Hotspot	33%	Non_Hotspot	3%
38663956G>C	C139W	139	0	0	0	0	0	NA	Hotspot	33%	Non_Hotspot	4%
38663957C>T	C139Y	139	0	0	0	0	0	NA	Hotspot	33%	Non_Hotspot	3%
38663939C>A	C145F	145	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38663940A>C	C145G	145	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38663940A>G	C145R	145	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38663939C>G	C145S	145	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38663940A>T	C145S	145	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38663938G>C	C145W	145	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38663939C>T	C145Y	145	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38595967C>A	C1539F	1539	1	0	0	0	1	NA	Non_Hotspot	6%	Non_Hotspot	11%
38595968A>C	C1539G	1539	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38595968A>G	C1539R	1539	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	5%
38595968A>T	C1539S	1539	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	5%
38595967C>G	C1539S	1539	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	5%
38595966G>C	C1539W	1539	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38595967C>T	C1539Y	1539	2	0	0	0	2	NA	Non_Hotspot	6%	Non_Hotspot	9%
38595859C>A	C1575F	1575	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	4%
38595860A>C	C1575G	1575	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	4%
38595860A>G	C1575R	1575	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	4%
38595860A>T	C1575S	1575	1	0	0	0	1	NA	Mild_Hotspot	14%	Non_Hotspot	4%
38595859C>G	C1575S	1575	1	0	0	0	1	NA	Mild_Hotspot	14%	Non_Hotspot	4%
38595858A>C	C1575W	1575	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	4%
38595859C>T	C1575Y	1575	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	4%
38592755C>A	C1703F	1703	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	4%
38592756A>C	C1703G	1703	0	0	0	0	0	NA	Mild_Hotspot	21%	Non_Hotspot	5%
38592756A>G	C1703R	1703	0	0	0	0	0	NA	Mild_Hotspot	21%	Non_Hotspot	5%
38592756A>T	C1703S	1703	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	4%
38592755C>G	C1703S	1703	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	4%
38592754G>C	C1703W	1703	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	4%
38592755C>T	C1703Y	1703	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	4%
38592680C>A	C1728F	1728	0	0	0	0	0	NA	Hotspot	54%	Non_Hotspot	4%
38592681A>C	C1728G	1728	0	0	0	0	0	NA	Hotspot	55%	Non_Hotspot	5%
38592681A>G	C1728R	1728	1	0	1	0	0	NA	Hotspot	57%	Non_Hotspot	9%
38592681A>T	C1728S	1728	0	0	0	0	0	NA	Hotspot	55%	Non_Hotspot	4%
38592680C>G	C1728S	1728	0	0	0	0	0	NA	Hotspot	54%	Non_Hotspot	4%
38592679G>C	C1728W	1728	1	0	1	0	0	NA	Hotspot	55%	Non_Hotspot	10%
38592680C>T	C1728Y	1728	1	0	1	0	0	NA	Hotspot	56%	Non_Hotspot	9%
38592638C>A	C1742F	1742	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	6%
38592639A>C	C1742G	1742	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	6%
38592639A>G	C1742R	1742	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	6%
38592639A>T	C1742S	1742	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	6%
38592638C>G	C1742S	1742	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	6%
38592637G>C	C1742W	1742	0	0	0	0	0	NA	Hotspot	31%	Non_Hotspot	5%
38592638C>T	C1742Y	1742	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	6%
38662400C>A	C182F	182	0	0	0	0	0	NA	Hotspot	34%	Non_Hotspot	4%
38662401A>C	C182G	182	0	0	0	0	0	NA	Hotspot	34%	Non_Hotspot	4%
38662401A>G	C182R	182	1	0	1	0	0	NA	Hotspot	37%	Non_Hotspot	10%
38662401A>T	C182S	182	0	0	0	0	0	NA	Hotspot	34%	Non_Hotspot	4%
38662400C>G	C182S	182	0	0	0	0	0	NA	Hotspot	34%	Non_Hotspot	4%
38662399G>C	C182W	182	0	0	0	0	0	NA	Hotspot	34%	Non_Hotspot	4%
38662400C>T	C182Y	182	1	0	0	0	1	NA	Hotspot	31%	Non_Hotspot	10%
38592314C>A	C1850F	1850	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	9%
38592315A>C	C1850G	1850	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	9%
38592315A>G	C1850R	1850	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	9%
38592314C>G	C1850S	1850	1	0	1	0	0	Partial_LOF	Hotspot	41%	Non_Hotspot	11%
38592315A>T	C1850S	1850	1	0	1	0	0	Partial_LOF	Hotspot	41%	Non_Hotspot	11%
38592313G>C	C1850W	1850	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	9%
38592314C>T	C1850Y	1850	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	9%
38651380C>A	C260F	260	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	29%
38651381A>C	C260G	260	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	29%
38651381A>G	C260R	260	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	29%
38651381A>T	C260S	260	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	29%
38651380C>G	C260S	260	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	29%
38651379G>C	C260W	260	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	29%
38651380C>T	C260Y	260	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	29%
38651320C>A	C280F	280	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	6%
38651321A>C	C280G	280	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	6%
38651321A>G	C280R	280	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	6%
38651321A>T	C280S	280	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	6%
38651320C>G	C280S	280	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	6%
38651319G>C	C280W	280	0	0	0	0	0	NA	Hotspot	51%	Non_Hotspot	6%
38651320C>T	C280Y	280	1	0	1	0	0	NA	Hotspot	54%	Non_Hotspot	10%
38649663C>A	C326F	326	0	0	0	0	0	NA	Hotspot	49%	Non_Hotspot	5%
38649664A>C	C326G	326	0	0	0	0	0	NA	Hotspot	49%	Non_Hotspot	6%
38649664A>G	C326R	326	0	0	0	0	0	NA	Hotspot	49%	Non_Hotspot	6%
38649664A>T	C326S	326	0	0	0	0	0	NA	Hotspot	49%	Non_Hotspot	6%
38649663C>G	C326S	326	0	0	0	0	0	NA	Hotspot	49%	Non_Hotspot	5%
38649662A>C	C326W	326	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	5%
38649663C>T	C326Y	326	0	0	0	0	0	NA	Hotspot	49%	Non_Hotspot	5%
38648296C>A	C335F	335	0	0	0	0	0	NA	Hotspot	59%	Non_Hotspot	5%
38648297A>C	C335G	335	0	0	0	0	0	NA	Hotspot	60%	Non_Hotspot	5%
38648297A>G	C335R	335	2	0	2	1	0	LOF	Hotspot	63%	Non_Hotspot	10%
38648296C>G	C335S	335	1	0	1	0	0	NA	Hotspot	60%	Non_Hotspot	10%
38648297A>T	C335S	335	1	0	1	0	0	NA	Hotspot	60%	Non_Hotspot	10%
38648295A>C	C335W	335	0	0	0	0	0	NA	Hotspot	59%	Non_Hotspot	5%
38648296C>T	C335Y	335	0	0	0	0	0	NA	Hotspot	59%	Non_Hotspot	5%
38648278C>A	C341F	341	0	0	0	0	0	NA	Non_Hotspot	12%	Hotspot	46%
38648279A>C	C341G	341	0	0	0	0	0	NA	Non_Hotspot	12%	Hotspot	46%
38648279A>G	C341R	341	0	0	0	0	0	NA	Non_Hotspot	12%	Hotspot	46%
38648279A>T	C341S	341	0	0	0	0	0	NA	Non_Hotspot	12%	Hotspot	46%
38648278C>G	C341S	341	0	0	0	0	0	NA	Non_Hotspot	12%	Hotspot	46%
38648277G>C	C341W	341	0	0	0	0	0	NA	Non_Hotspot	11%	Hotspot	45%
38648278C>T	C341Y	341	2	2	0	0	0	NA	Non_Hotspot	9%	Hotspot	56%
38648182C>A	C373F	373	0	0	0	0	0	Mild_LOF	Hotspot	36%	Mild_Hotspot	14%
38648183A>C	C373G	373	0	0	0	0	0	NA	Hotspot	37%	Mild_Hotspot	15%
38648183A>G	C373R	373	0	0	0	0	0	NA	Hotspot	38%	Mild_Hotspot	16%
38648183A>T	C373S	373	0	0	0	0	0	NA	Hotspot	37%	Mild_Hotspot	15%
38648182C>G	C373S	373	0	0	0	0	0	NA	Hotspot	36%	Mild_Hotspot	15%
38648181G>C	C373W	373	0	0	0	0	0	NA	Hotspot	37%	Mild_Hotspot	15%
38648182C>T	C373Y	373	0	0	0	0	0	Mild_LOF	Hotspot	35%	Mild_Hotspot	12%
38646272C>A	C489F	489	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38646273A>C	C489G	489	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38646273A>G	C489R	489	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	1%
38646273A>T	C489S	489	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	1%
38646272C>G	C489S	489	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38646271A>C	C489W	489	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38646272C>T	C489Y	489	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38645303C>A	C597F	597	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38645304A>C	C597G	597	1	0	0	0	1	NA	Non_Hotspot	4%	Non_Hotspot	11%
38645304A>G	C597R	597	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38645304A>T	C597S	597	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38645303C>G	C597S	597	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38645302G>C	C597W	597	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38645303C>T	C597Y	597	1	0	0	0	1	NA	Non_Hotspot	4%	Non_Hotspot	10%
38640486C>A	C649F	649	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38640487A>C	C649G	649	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38640487A>G	C649R	649	1	0	0	0	1	NA	Non_Hotspot	6%	Non_Hotspot	2%
38640487A>T	C649S	649	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38640486C>G	C649S	649	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38640485A>C	C649W	649	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38640486C>T	C649Y	649	2	0	0	0	2	NA	Non_Hotspot	6%	Non_Hotspot	5%
38639434C>A	C683F	683	0	0	0	0	0	NA	Mild_Hotspot	21%	Mild_Hotspot	18%
38639435A>C	C683G	683	1	0	1	0	0	NA	Mild_Hotspot	25%	Mild_Hotspot	19%
38639435A>G	C683R	683	6	6	0	0	0	NA	Mild_Hotspot	15%	Mild_Hotspot	41%
38639434C>G	C683S	683	1	0	0	0	1	NA	Mild_Hotspot	19%	Mild_Hotspot	18%
38639435A>T	C683S	683	1	0	0	0	1	NA	Mild_Hotspot	20%	Mild_Hotspot	18%
38639433A>C	C683W	683	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	18%
38639434C>T	C683Y	683	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	18%
38639425C>A	C686F	686	1	0	0	0	1	NA	Non_Hotspot	12%	Non_Hotspot	12%
38639426A>C	C686G	686	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	8%
38639426A>G	C686R	686	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	7%
38639426A>T	C686S	686	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	8%
38639425C>G	C686S	686	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	8%
38639424G>C	C686W	686	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	7%
38639425C>T	C686Y	686	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	8%
38639386C>A	C699F	699	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	6%
38639387A>C	C699G	699	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	6%
38639387A>G	C699R	699	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	6%
38639387A>T	C699S	699	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	6%
38639386C>G	C699S	699	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	6%
38639385G>C	C699W	699	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	6%
38639386C>T	C699Y	699	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	6%
38639383C>A	C700F	700	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	6%
38639384A>C	C700G	700	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	6%
38639384A>G	C700R	700	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	6%
38639384A>T	C700S	700	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	6%
38639383C>G	C700S	700	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	6%
38639382G>C	C700W	700	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	6%
38639383C>T	C700Y	700	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	6%
38639305C>A	C726F	726	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	7%
38639306A>C	C726G	726	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	7%
38639306A>G	C726R	726	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	8%
38639306A>T	C726S	726	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	7%
38639305C>G	C726S	726	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	7%
38639304G>C	C726W	726	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	7%
38639305C>T	C726Y	726	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	7%
38627282C>A	C896F	896	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	9%
38627283A>C	C896G	896	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	9%
38627283A>G	C896R	896	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	9%
38627282C>G	C896S	896	1	0	1	0	0	NA	Hotspot	53%	Non_Hotspot	8%
38627283A>T	C896S	896	1	0	1	0	0	NA	Hotspot	53%	Non_Hotspot	8%
38627281A>C	C896W	896	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	8%
38627282C>T	C896Y	896	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	9%
38627252C>A	C906F	906	0	0	0	0	0	NA	Hotspot	43%	Non_Hotspot	9%
38627253A>C	C906G	906	0	0	0	0	0	NA	Hotspot	43%	Non_Hotspot	9%
38627253A>G	C906R	906	0	0	0	0	0	NA	Hotspot	44%	Non_Hotspot	9%
38627253A>T	C906S	906	0	0	0	0	0	NA	Hotspot	43%	Non_Hotspot	9%
38627252C>G	C906S	906	0	0	0	0	0	NA	Hotspot	43%	Non_Hotspot	9%
38627251G>C	C906W	906	0	0	0	0	0	NA	Hotspot	43%	Non_Hotspot	9%
38627252C>T	C906Y	906	0	0	0	0	0	NA	Hotspot	44%	Non_Hotspot	9%
38627225C>A	C915F	915	0	0	0	0	0	NA	Hotspot	54%	Non_Hotspot	6%
38627226A>C	C915G	915	0	0	0	0	0	NA	Hotspot	54%	Non_Hotspot	6%
38627226A>G	C915R	915	1	0	1	0	0	NA	Hotspot	56%	Non_Hotspot	10%
38627226A>T	C915S	915	0	0	0	0	0	NA	Hotspot	54%	Non_Hotspot	6%
38627225C>G	C915S	915	0	0	0	0	0	NA	Hotspot	54%	Non_Hotspot	6%
38627224G>C	C915W	915	0	0	0	0	0	NA	Hotspot	54%	Non_Hotspot	6%
38627225C>T	C915Y	915	0	0	0	0	0	NA	Hotspot	54%	Non_Hotspot	6%
0.>.	C981A	981	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	43%
38622708C>A	C981F	981	1	1	0	0	0	NA	Non_Hotspot	7%	Hotspot	47%
38622709A>C	C981G	981	0	0	0	0	0	NA	Non_Hotspot	6%	Hotspot	41%
38622709A>G	C981R	981	0	0	0	0	0	NA	Non_Hotspot	6%	Hotspot	42%
38622709A>T	C981S	981	0	0	0	0	0	NA	Non_Hotspot	6%	Hotspot	41%
38622708C>G	C981S	981	0	0	0	0	0	NA	Non_Hotspot	6%	Hotspot	41%
38622707G>C	C981W	981	0	0	0	0	0	NA	Non_Hotspot	6%	Hotspot	41%
38622708C>T	C981Y	981	0	0	0	0	0	NA	Non_Hotspot	6%	Hotspot	41%
38622705C>A	C982F	982	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	14%
38622706A>C	C982G	982	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	14%
38622706A>G	C982R	982	29	1	0	5	28	NA	Non_Hotspot	3%	Mild_Hotspot	9%
38622706A>T	C982S	982	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	14%
38622705C>G	C982S	982	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	14%
38622704A>C	C982W	982	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	14%
38622705C>T	C982Y	982	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	14%
38622528T>G	D1041A	1041	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38622527A>C	D1041E	1041	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38622527A>T	D1041E	1041	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38622528T>C	D1041G	1041	1	0	0	0	1	NA	Non_Hotspot	6%	Non_Hotspot	6%
38622529C>G	D1041H	1041	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38622529C>T	D1041N	1041	18	1	1	0	16	NA	Non_Hotspot	5%	Non_Hotspot	6%
38622528T>A	D1041V	1041	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38622529C>A	D1041Y	1041	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38622486T>G	D1055A	1055	0	0	0	0	0	NA	Hotspot	43%	Non_Hotspot	4%
38622485G>C	D1055E	1055	0	0	0	0	0	NA	Hotspot	42%	Non_Hotspot	3%
38622485G>T	D1055E	1055	0	0	0	0	0	NA	Hotspot	42%	Non_Hotspot	3%
38622486T>C	D1055G	1055	1	0	1	0	0	NA	Hotspot	51%	Non_Hotspot	8%
38622487C>G	D1055H	1055	0	0	0	0	0	NA	Hotspot	43%	Non_Hotspot	4%
38622487C>T	D1055N	1055	0	0	0	0	0	NA	Hotspot	42%	Non_Hotspot	4%
38622486T>A	D1055V	1055	0	0	0	0	0	NA	Hotspot	43%	Non_Hotspot	4%
38622487C>A	D1055Y	1055	0	0	0	0	0	NA	Hotspot	43%	Non_Hotspot	4%
38622480T>G	D1057A	1057	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	3%
38622479A>C	D1057E	1057	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	3%
38622479A>T	D1057E	1057	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	3%
38622480T>C	D1057G	1057	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	3%
38622481C>G	D1057H	1057	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	3%
38622481C>T	D1057N	1057	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	3%
38622480T>A	D1057V	1057	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	3%
38622481C>A	D1057Y	1057	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	3%
38622477T>G	D1058A	1058	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38622476G>C	D1058E	1058	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	3%
38622476G>T	D1058E	1058	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	3%
38622477T>C	D1058G	1058	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38622478C>G	D1058H	1058	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38622478C>T	D1058N	1058	0	0	0	0	0	NA	Mild_Hotspot	11%	Non_Hotspot	2%
38622477T>A	D1058V	1058	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	4%
38622478C>A	D1058Y	1058	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38622465T>G	D1062A	1062	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622464A>C	D1062E	1062	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38622464A>T	D1062E	1062	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38622465T>C	D1062G	1062	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622466C>G	D1062H	1062	1	0	0	0	1	NA	Non_Hotspot	6%	Non_Hotspot	4%
38622466C>T	D1062N	1062	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38622465T>A	D1062V	1062	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622466C>A	D1062Y	1062	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38620943T>G	D1091A	1091	1	0	0	0	1	NA	Non_Hotspot	3%	Non_Hotspot	3%
38620942A>C	D1091E	1091	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620942A>T	D1091E	1091	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620943T>C	D1091G	1091	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620944C>G	D1091H	1091	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620944C>T	D1091N	1091	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620943T>A	D1091V	1091	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620944C>A	D1091Y	1091	1	0	0	0	1	NA	Non_Hotspot	2%	Non_Hotspot	6%
38620874T>G	D1114A	1114	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	25%
38620873G>C	D1114E	1114	10	6	0	0	4	NA	Non_Hotspot	0%	Mild_Hotspot	38%
38620873G>T	D1114E	1114	10	6	0	0	4	NA	Non_Hotspot	0%	Mild_Hotspot	38%
38620874T>C	D1114G	1114	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	25%
38620875C>G	D1114H	1114	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	25%
38620875C>T	D1114N	1114	8	3	1	1	4	NA	Non_Hotspot	4%	Mild_Hotspot	29%
38620874T>A	D1114V	1114	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	25%
38620875C>A	D1114Y	1114	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	25%
38618262T>G	D1134A	1134	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38618261G>C	D1134E	1134	1	0	0	0	1	NA	Non_Hotspot	1%	Non_Hotspot	1%
38618261G>T	D1134E	1134	1	0	0	0	1	NA	Non_Hotspot	1%	Non_Hotspot	1%
38618262T>C	D1134G	1134	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38618263C>G	D1134H	1134	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38618263C>T	D1134N	1134	1	0	0	0	1	NA	Non_Hotspot	1%	Non_Hotspot	2%
38618262T>A	D1134V	1134	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38618263C>A	D1134Y	1134	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38618235T>G	D1143A	1143	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	4%
38618234G>C	D1143E	1143	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	3%
38618234G>T	D1143E	1143	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	3%
38618235T>C	D1143G	1143	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	4%
38618236C>G	D1143H	1143	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	4%
38618236C>T	D1143N	1143	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	4%
38618235T>A	D1143V	1143	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	4%
38618236C>A	D1143Y	1143	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	4%
38618196T>G	D1156A	1156	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38618195G>C	D1156E	1156	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	3%
38618195G>T	D1156E	1156	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	3%
38618196T>C	D1156G	1156	9	0	0	0	9	NA	Non_Hotspot	4%	Non_Hotspot	1%
38618197C>G	D1156H	1156	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38618197C>T	D1156N	1156	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	3%
38618196T>A	D1156V	1156	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38618197C>A	D1156Y	1156	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38618184T>G	D1160A	1160	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	17%
38618183A>C	D1160E	1160	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	16%
38618183A>T	D1160E	1160	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	16%
38618184T>C	D1160G	1160	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	17%
38618185C>G	D1160H	1160	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	17%
38618185C>T	D1160N	1160	0	0	0	0	0	NA	Non_Hotspot	3%	Mild_Hotspot	16%
38618184T>A	D1160V	1160	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	17%
38618185C>A	D1160Y	1160	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	17%
38618175T>G	D1163A	1163	0	0	0	0	0	NA	Non_Hotspot	5%	Hotspot	30%
38618174G>C	D1163E	1163	1	1	0	0	0	NA	Non_Hotspot	2%	Hotspot	34%
38618174G>T	D1163E	1163	1	1	0	0	0	NA	Non_Hotspot	2%	Hotspot	34%
38618175T>C	D1163G	1163	1	0	0	0	1	NA	Non_Hotspot	7%	Hotspot	26%
38618176C>G	D1163H	1163	0	0	0	0	0	NA	Non_Hotspot	5%	Hotspot	30%
38618176C>T	D1163N	1163	0	0	0	0	0	NA	Non_Hotspot	4%	Hotspot	29%
38618175T>A	D1163V	1163	0	0	0	0	0	NA	Non_Hotspot	6%	Hotspot	30%
38618176C>A	D1163Y	1163	1	0	0	0	1	NA	Non_Hotspot	7%	Hotspot	29%
38618166T>G	D1166A	1166	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	27%
38618165G>C	D1166E	1166	0	0	0	0	0	NA	Non_Hotspot	3%	Mild_Hotspot	26%
38618165G>T	D1166E	1166	0	0	0	0	0	NA	Non_Hotspot	3%	Mild_Hotspot	26%
38618166T>C	D1166G	1166	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	27%
38618167C>G	D1166H	1166	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	27%
38618167C>T	D1166N	1166	1	1	0	0	0	NA	Non_Hotspot	10%	Mild_Hotspot	32%
38618166T>A	D1166V	1166	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	28%
38618167C>A	D1166Y	1166	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	27%
38616909T>G	D1182A	1182	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38616908G>T	D1182E	1182	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38616908G>C	D1182E	1182	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38616909T>C	D1182G	1182	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38616910C>G	D1182H	1182	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38616910C>T	D1182N	1182	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38616909T>A	D1182V	1182	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38616910C>A	D1182Y	1182	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38608063T>G	D1226A	1226	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	8%
38608062G>C	D1226E	1226	0	0	0	0	0	NA	Hotspot	35%	Non_Hotspot	8%
38608062G>T	D1226E	1226	0	0	0	0	0	NA	Hotspot	35%	Non_Hotspot	8%
38608063T>C	D1226G	1226	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	8%
38608064C>G	D1226H	1226	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	8%
38608064C>T	D1226N	1226	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	8%
38608063T>A	D1226V	1226	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	8%
38608064C>A	D1226Y	1226	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	8%
38608012T>G	D1243A	1243	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	4%
38608011G>C	D1243E	1243	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	4%
38608011G>T	D1243E	1243	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	4%
38608012T>C	D1243G	1243	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	4%
38608013C>G	D1243H	1243	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	4%
38608013C>T	D1243N	1243	47	0	5	0	42	Normal	Mild_Hotspot	10%	Non_Hotspot	2%
38608012T>A	D1243V	1243	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	4%
38608013C>A	D1243Y	1243	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	4%
38607916T>G	D1275A	1275	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	8%
38607915G>T	D1275E	1275	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	7%
38607915G>C	D1275E	1275	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	7%
38607916T>C	D1275G	1275	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	8%
38607917C>G	D1275H	1275	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	8%
38607917C>T	D1275N	1275	28	0	3	37	25	Partial_LOF	Mild_Hotspot	12%	Non_Hotspot	3%
38607916T>A	D1275V	1275	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	8%
38607917C>A	D1275Y	1275	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	8%
38607901T>G	D1280A	1280	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	15%
38607900G>C	D1280E	1280	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	15%
38607900G>T	D1280E	1280	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	15%
38607901T>C	D1280G	1280	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	15%
38607902C>G	D1280H	1280	0	0	0	0	0	NA	Mild_Hotspot	24%	Mild_Hotspot	16%
38607902C>T	D1280N	1280	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	15%
38607901T>A	D1280V	1280	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	15%
38607902C>A	D1280Y	1280	0	0	0	0	0	NA	Mild_Hotspot	24%	Mild_Hotspot	16%
38601774T>G	D1370A	1370	1	0	0	0	1	NA	Non_Hotspot	8%	Non_Hotspot	1%
38601773G>T	D1370E	1370	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38601773G>C	D1370E	1370	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38601774T>C	D1370G	1370	15	0	0	0	15	Normal	Non_Hotspot	5%	Non_Hotspot	0%
38601775C>G	D1370H	1370	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38601775C>T	D1370N	1370	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	2%
38601774T>A	D1370V	1370	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38601775C>A	D1370Y	1370	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38601675T>G	D1403A	1403	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	5%
38601674G>C	D1403E	1403	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	4%
38601674G>T	D1403E	1403	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	4%
38601675T>C	D1403G	1403	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	4%
38601676C>G	D1403H	1403	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	4%
38601676C>T	D1403N	1403	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	4%
38601675T>A	D1403V	1403	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	4%
38601676C>A	D1403Y	1403	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	4%
38598753T>G	D1423A	1423	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	4%
38598752G>C	D1423E	1423	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	3%
38598752G>T	D1423E	1423	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	3%
38598753T>C	D1423G	1423	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	4%
38598754C>G	D1423H	1423	1	0	0	0	1	NA	Mild_Hotspot	20%	Non_Hotspot	5%
38598754C>T	D1423N	1423	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	4%
38598753T>A	D1423V	1423	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	4%
38598754C>A	D1423Y	1423	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	4%
38598732T>G	D1430A	1430	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	7%
38598731G>T	D1430E	1430	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	7%
38598731G>C	D1430E	1430	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	7%
38598732T>C	D1430G	1430	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	7%
38598733C>G	D1430H	1430	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	7%
38598733C>T	D1430N	1430	2	0	2	0	0	LOF	Hotspot	54%	Non_Hotspot	6%
38598732T>A	D1430V	1430	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	7%
38598733C>A	D1430Y	1430	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	7%
38597957T>G	D1471A	1471	0	0	0	0	0	NA	Non_Hotspot	11%	Hotspot	51%
38597956G>T	D1471E	1471	0	0	0	0	0	NA	Non_Hotspot	10%	Hotspot	50%
38597956G>C	D1471E	1471	0	0	0	0	0	NA	Non_Hotspot	10%	Hotspot	50%
38597957T>C	D1471G	1471	0	0	0	0	0	NA	Non_Hotspot	11%	Hotspot	51%
38597958C>G	D1471H	1471	0	0	0	0	0	NA	Non_Hotspot	11%	Hotspot	51%
38597958C>T	D1471N	1471	0	0	0	0	0	NA	Non_Hotspot	11%	Hotspot	50%
38597957T>A	D1471V	1471	0	0	0	0	0	NA	Non_Hotspot	11%	Hotspot	51%
38597958C>A	D1471Y	1471	0	0	0	0	0	NA	Non_Hotspot	11%	Hotspot	51%
38597238T>G	D1484A	1484	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	43%
38597237G>T	D1484E	1484	0	0	0	0	0	NA	Non_Hotspot	5%	Hotspot	42%
38597237G>C	D1484E	1484	0	0	0	0	0	NA	Non_Hotspot	5%	Hotspot	42%
38597238T>C	D1484G	1484	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	43%
38597239C>G	D1484H	1484	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	43%
38597239C>T	D1484N	1484	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	43%
38597238T>A	D1484V	1484	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	43%
38597239C>A	D1484Y	1484	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	43%
38596015T>G	D1523A	1523	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	10%
38596014G>C	D1523E	1523	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	10%
38596014G>T	D1523E	1523	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	10%
38596015T>C	D1523G	1523	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	10%
38596016C>G	D1523H	1523	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	10%
38596016C>T	D1523N	1523	10	0	0	0	10	NA	Mild_Hotspot	7%	Non_Hotspot	7%
38596015T>A	D1523V	1523	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	10%
38596016C>A	D1523Y	1523	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	10%
38663918T>G	D152A	152	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38663917G>C	D152E	152	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38663917G>T	D152E	152	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38663918T>C	D152G	152	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38663919C>G	D152H	152	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38663919C>T	D152N	152	3	0	0	0	3	NA	Non_Hotspot	2%	Non_Hotspot	5%
38663918T>A	D152V	152	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38663919C>A	D152Y	152	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38595991T>G	D1531A	1531	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	6%
38595990G>C	D1531E	1531	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38595990G>T	D1531E	1531	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38595991T>C	D1531G	1531	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	5%
38595992C>G	D1531H	1531	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	6%
38595992C>T	D1531N	1531	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	5%
38595991T>A	D1531V	1531	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	6%
38595992C>A	D1531Y	1531	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	6%
38595934T>G	D1550A	1550	0	0	0	0	0	NA	Mild_Hotspot	23%	Non_Hotspot	5%
38595933A>C	D1550E	1550	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	4%
38595933A>T	D1550E	1550	0	0	0	0	0	NA	Mild_Hotspot	22%	Non_Hotspot	4%
38595934T>C	D1550G	1550	0	0	0	0	0	NA	Mild_Hotspot	23%	Non_Hotspot	5%
38595935C>G	D1550H	1550	0	0	0	0	0	NA	Mild_Hotspot	23%	Non_Hotspot	5%
38595935C>T	D1550N	1550	0	0	0	0	0	NA	Mild_Hotspot	23%	Non_Hotspot	5%
38595934T>A	D1550V	1550	0	0	0	0	0	NA	Mild_Hotspot	23%	Non_Hotspot	5%
38595935C>A	D1550Y	1550	0	0	0	0	0	NA	Mild_Hotspot	23%	Non_Hotspot	5%
38595931T>G	D1551A	1551	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	4%
38595930G>C	D1551E	1551	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	3%
38595930G>T	D1551E	1551	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	3%
38595931T>C	D1551G	1551	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	4%
38595932C>G	D1551H	1551	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	4%
38595932C>T	D1551N	1551	2	0	0	0	2	NA	Mild_Hotspot	12%	Non_Hotspot	4%
38595931T>A	D1551V	1551	0	0	0	0	0	NA	Mild_Hotspot	16%	Non_Hotspot	4%
38595932C>A	D1551Y	1551	1	0	0	0	1	NA	Mild_Hotspot	18%	Non_Hotspot	6%
38595799T>G	D1595A	1595	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	25%
38595798G>C	D1595E	1595	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	25%
38595798G>T	D1595E	1595	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	25%
38595799T>C	D1595G	1595	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	25%
38595800C>G	D1595H	1595	0	0	0	1	0	Normal	Non_Hotspot	6%	Mild_Hotspot	25%
38595800C>T	D1595N	1595	0	0	0	3	0	Normal	Non_Hotspot	7%	Mild_Hotspot	24%
38595799T>A	D1595V	1595	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	25%
38595800C>A	D1595Y	1595	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	25%
38593034T>G	D1610A	1610	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	12%
38593033G>C	D1610E	1610	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	11%
38593033G>T	D1610E	1610	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	11%
38593034T>C	D1610G	1610	1	0	0	0	1	NA	Non_Hotspot	8%	Mild_Hotspot	6%
38593035C>G	D1610H	1610	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	12%
38593035C>T	D1610N	1610	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	11%
38593034T>A	D1610V	1610	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	12%
38593035C>A	D1610Y	1610	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	12%
38592797T>G	D1689A	1689	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	4%
38592796G>C	D1689E	1689	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38592796G>T	D1689E	1689	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38592797T>C	D1689G	1689	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	4%
38592798C>G	D1689H	1689	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	4%
38592798C>T	D1689N	1689	1	0	0	0	1	NA	Mild_Hotspot	8%	Non_Hotspot	8%
38592797T>A	D1689V	1689	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	4%
38592798C>A	D1689Y	1689	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	4%
38592794T>G	D1690A	1690	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	4%
38592793G>C	D1690E	1690	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	4%
38592793G>T	D1690E	1690	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	4%
38592794T>C	D1690G	1690	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	4%
38592795C>G	D1690H	1690	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	4%
38592795C>T	D1690N	1690	3	0	2	0	1	Partial_LOF	Hotspot	40%	Non_Hotspot	5%
38592794T>A	D1690V	1690	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	4%
38592795C>A	D1690Y	1690	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	4%
38592722T>G	D1714A	1714	0	0	0	0	0	NA	Hotspot	55%	Non_Hotspot	4%
38592721A>C	D1714E	1714	0	0	0	0	0	NA	Hotspot	54%	Non_Hotspot	4%
38592721A>T	D1714E	1714	0	0	0	0	0	NA	Hotspot	54%	Non_Hotspot	4%
38592722T>C	D1714G	1714	1	0	1	0	0	Partial_LOF	Hotspot	58%	Non_Hotspot	4%
38592723C>G	D1714H	1714	0	0	0	0	0	NA	Hotspot	56%	Non_Hotspot	5%
38592723C>T	D1714N	1714	0	0	0	0	0	NA	Hotspot	54%	Non_Hotspot	4%
38592722T>A	D1714V	1714	0	0	0	0	0	NA	Hotspot	56%	Non_Hotspot	5%
38592723C>A	D1714Y	1714	0	0	0	0	0	NA	Hotspot	56%	Non_Hotspot	5%
38592677T>G	D1729A	1729	0	0	0	0	0	NA	Mild_Hotspot	27%	Non_Hotspot	4%
38592676G>C	D1729E	1729	0	0	0	0	0	NA	Mild_Hotspot	26%	Non_Hotspot	4%
38592676G>T	D1729E	1729	0	0	0	0	0	NA	Mild_Hotspot	26%	Non_Hotspot	4%
38592677T>C	D1729G	1729	0	0	0	0	0	NA	Mild_Hotspot	27%	Non_Hotspot	4%
38592678C>G	D1729H	1729	0	0	0	0	0	NA	Mild_Hotspot	26%	Non_Hotspot	4%
38592678C>T	D1729N	1729	4	0	0	0	4	NA	Mild_Hotspot	19%	Non_Hotspot	7%
38592677T>A	D1729V	1729	0	0	0	0	0	NA	Mild_Hotspot	27%	Non_Hotspot	4%
38592678C>A	D1729Y	1729	0	0	0	0	0	NA	Mild_Hotspot	26%	Non_Hotspot	4%
38592641T>G	D1741A	1741	0	0	0	0	0	NA	Mild_Hotspot	25%	Non_Hotspot	4%
38592640G>T	D1741E	1741	1	0	0	0	1	NA	Mild_Hotspot	19%	Non_Hotspot	5%
38592640G>C	D1741E	1741	1	0	0	0	1	NA	Mild_Hotspot	19%	Non_Hotspot	5%
38592641T>C	D1741G	1741	0	0	0	0	0	NA	Mild_Hotspot	25%	Non_Hotspot	4%
38592642C>G	D1741H	1741	0	0	0	0	0	NA	Mild_Hotspot	24%	Non_Hotspot	4%
38592642C>T	D1741N	1741	3	0	0	0	3	NA	Mild_Hotspot	16%	Non_Hotspot	4%
38592641T>A	D1741V	1741	0	0	0	0	0	NA	Mild_Hotspot	26%	Non_Hotspot	5%
38592642C>A	D1741Y	1741	1	0	1	1	0	NA	Mild_Hotspot	26%	Non_Hotspot	10%
38592497T>G	D1789A	1789	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	36%
38592496G>T	D1789E	1789	0	0	0	0	0	NA	Non_Hotspot	6%	Hotspot	35%
38592496G>C	D1789E	1789	0	0	0	0	0	NA	Non_Hotspot	6%	Hotspot	35%
38592497T>C	D1789G	1789	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	36%
38592498C>G	D1789H	1789	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	36%
38592498C>T	D1789N	1789	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	36%
38592497T>A	D1789V	1789	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	36%
38592498C>A	D1789Y	1789	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	36%
38592494T>G	D1790A	1790	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	39%
38592493G>T	D1790E	1790	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	39%
38592493G>C	D1790E	1790	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	39%
38592494T>C	D1790G	1790	45	38	1	0	6	GOF	Non_Hotspot	4%	Hotspot	71%
38592495C>G	D1790H	1790	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	39%
38592495C>T	D1790N	1790	5	0	0	1	5	NA	Non_Hotspot	5%	Hotspot	31%
38592494T>A	D1790V	1790	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	39%
38592495C>A	D1790Y	1790	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	39%
38592488T>G	D1792A	1792	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	14%
38592487A>C	D1792E	1792	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	12%
38592487A>T	D1792E	1792	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	12%
38592488T>C	D1792G	1792	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	14%
38592489C>G	D1792H	1792	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	14%
38592489C>T	D1792N	1792	5	0	0	1	5	NA	Non_Hotspot	4%	Mild_Hotspot	11%
38592488T>A	D1792V	1792	1	0	0	0	1	NA	Non_Hotspot	8%	Mild_Hotspot	11%
38592489C>A	D1792Y	1792	1	0	0	0	1	NA	Non_Hotspot	8%	Mild_Hotspot	13%
38592458T>G	D1802A	1802	0	0	0	0	0	NA	Non_Hotspot	10%	Mild_Hotspot	28%
38592457G>T	D1802E	1802	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	28%
38592457G>C	D1802E	1802	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	28%
38592458T>C	D1802G	1802	0	0	0	0	0	NA	Non_Hotspot	10%	Mild_Hotspot	28%
38592459C>G	D1802H	1802	0	0	0	0	0	NA	Non_Hotspot	10%	Mild_Hotspot	28%
38592459C>T	D1802N	1802	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	28%
38592458T>A	D1802V	1802	0	0	0	0	0	NA	Non_Hotspot	10%	Mild_Hotspot	28%
38592459C>A	D1802Y	1802	0	0	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	28%
38592416T>G	D1816A	1816	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38592415G>C	D1816E	1816	1	0	0	0	1	NA	Non_Hotspot	2%	Non_Hotspot	2%
38592415G>T	D1816E	1816	1	0	0	0	1	NA	Non_Hotspot	2%	Non_Hotspot	2%
38592416T>C	D1816G	1816	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	5%
38592417C>G	D1816H	1816	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	5%
38592417C>T	D1816N	1816	1	0	0	0	1	NA	Non_Hotspot	10%	Non_Hotspot	5%
38592416T>A	D1816V	1816	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	5%
38592417C>A	D1816Y	1816	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	5%
38592407T>G	D1819A	1819	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	6%
38592406A>C	D1819E	1819	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38592406A>T	D1819E	1819	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38592407T>C	D1819G	1819	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	6%
38592408C>G	D1819H	1819	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	6%
38592408C>T	D1819N	1819	72	1	0	1	71	Mild_LOF	Non_Hotspot	1%	Non_Hotspot	2%
38592407T>A	D1819V	1819	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	6%
38592408C>A	D1819Y	1819	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	7%
38592347T>G	D1839A	1839	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	44%
38592346G>C	D1839E	1839	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	44%
38592346G>T	D1839E	1839	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	44%
38592347T>C	D1839G	1839	1	1	0	0	0	NA	Non_Hotspot	6%	Hotspot	48%
38592348C>G	D1839H	1839	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	44%
38592348C>T	D1839N	1839	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	44%
38592347T>A	D1839V	1839	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	44%
38592348C>A	D1839Y	1839	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	44%
38592326T>G	D1846A	1846	0	0	0	0	0	NA	Non_Hotspot	13%	Non_Hotspot	8%
38592325G>C	D1846E	1846	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	7%
38592325G>T	D1846E	1846	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	7%
38592326T>C	D1846G	1846	0	0	0	0	0	NA	Non_Hotspot	13%	Non_Hotspot	8%
38592327C>G	D1846H	1846	0	0	0	0	0	NA	Non_Hotspot	13%	Non_Hotspot	8%
38592327C>T	D1846N	1846	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	7%
38592326T>A	D1846V	1846	0	0	0	0	0	NA	Non_Hotspot	13%	Non_Hotspot	8%
38592327C>A	D1846Y	1846	0	0	0	0	0	NA	Non_Hotspot	13%	Non_Hotspot	8%
38592308T>G	D1852A	1852	0	0	0	0	0	NA	Non_Hotspot	13%	Non_Hotspot	6%
38592307G>C	D1852E	1852	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	6%
38592307G>T	D1852E	1852	0	0	0	0	0	NA	Non_Hotspot	12%	Non_Hotspot	6%
38592308T>C	D1852G	1852	0	0	0	0	0	NA	Non_Hotspot	13%	Non_Hotspot	6%
38592309C>G	D1852H	1852	0	0	0	0	0	NA	Non_Hotspot	13%	Non_Hotspot	6%
38592309C>T	D1852N	1852	0	0	0	0	0	NA	Non_Hotspot	13%	Non_Hotspot	6%
38592308T>A	D1852V	1852	1	0	0	0	1	NA	Non_Hotspot	12%	Non_Hotspot	7%
38592309C>A	D1852Y	1852	0	0	0	0	0	NA	Non_Hotspot	13%	Non_Hotspot	6%
38592257T>G	D1869A	1869	0	0	0	0	0	NA	Mild_Hotspot	24%	Mild_Hotspot	14%
38592256G>C	D1869E	1869	0	0	0	0	0	NA	Mild_Hotspot	22%	Mild_Hotspot	13%
38592256G>T	D1869E	1869	0	0	0	0	0	NA	Mild_Hotspot	22%	Mild_Hotspot	13%
38592257T>C	D1869G	1869	0	0	0	0	0	NA	Mild_Hotspot	24%	Mild_Hotspot	14%
38592258C>G	D1869H	1869	0	0	0	0	0	NA	Mild_Hotspot	24%	Mild_Hotspot	14%
38592258C>T	D1869N	1869	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	14%
38592257T>A	D1869V	1869	0	0	0	0	0	NA	Mild_Hotspot	24%	Mild_Hotspot	14%
38592258C>A	D1869Y	1869	0	0	0	0	0	NA	Mild_Hotspot	24%	Mild_Hotspot	14%
38662373T>G	D191A	191	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	6%
38662372G>C	D191E	191	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	6%
38662372G>T	D191E	191	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	6%
38662373T>C	D191G	191	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	6%
38662374C>G	D191H	191	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	6%
38662374C>T	D191N	191	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	6%
38662373T>A	D191V	191	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	6%
38662374C>A	D191Y	191	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	6%
38592044T>G	D1940A	1940	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38592043A>C	D1940E	1940	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38592043A>T	D1940E	1940	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38592044T>C	D1940G	1940	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38592045C>G	D1940H	1940	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38592045C>T	D1940N	1940	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38592044T>A	D1940V	1940	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38592045C>A	D1940Y	1940	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38591930T>G	D1978A	1978	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	22%
38591929G>C	D1978E	1978	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	21%
38591929G>T	D1978E	1978	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	21%
38591930T>C	D1978G	1978	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	22%
38591931C>G	D1978H	1978	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	21%
38591931C>T	D1978N	1978	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	21%
38591930T>A	D1978V	1978	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	22%
38591931C>A	D1978Y	1978	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	21%
38662355T>G	D197A	197	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	5%
38662354G>C	D197E	197	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38662354G>T	D197E	197	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38662355T>C	D197G	197	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	5%
38662356C>G	D197H	197	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	5%
38662356C>T	D197N	197	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	5%
38662355T>A	D197V	197	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	5%
38662356C>A	D197Y	197	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	5%
38591906T>G	D1986A	1986	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38591905A>C	D1986E	1986	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38591905A>T	D1986E	1986	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38591906T>C	D1986G	1986	1	0	0	0	1	NA	Non_Hotspot	3%	Non_Hotspot	7%
38591907C>G	D1986H	1986	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38591907C>T	D1986N	1986	6	0	0	0	6	NA	Non_Hotspot	1%	Non_Hotspot	5%
38591906T>A	D1986V	1986	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38591907C>A	D1986Y	1986	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38591882T>G	D1994A	1994	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38591881G>C	D1994E	1994	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38591881G>T	D1994E	1994	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38591882T>C	D1994G	1994	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38591883C>G	D1994H	1994	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38591883C>T	D1994N	1994	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38591882T>A	D1994V	1994	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38591883C>A	D1994Y	1994	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38591864T>G	D2000A	2000	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38591863A>C	D2000E	2000	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	2%
38591863A>T	D2000E	2000	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	2%
38591864T>C	D2000G	2000	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38591865C>G	D2000H	2000	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38591865C>T	D2000N	2000	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38591864T>A	D2000V	2000	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38591865C>A	D2000Y	2000	3	0	0	0	3	NA	Non_Hotspot	4%	Non_Hotspot	7%
38591855T>G	D2003A	2003	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	4%
38591854G>C	D2003E	2003	0	0	0	0	0	NA	Mild_Hotspot	11%	Non_Hotspot	4%
38591854G>T	D2003E	2003	0	0	0	0	0	NA	Mild_Hotspot	11%	Non_Hotspot	4%
38591855T>C	D2003G	2003	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	4%
38591856C>G	D2003H	2003	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	4%
38591856C>T	D2003N	2003	4	0	0	1	4	NA	Mild_Hotspot	8%	Non_Hotspot	8%
38591855T>A	D2003V	2003	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	5%
38591856C>A	D2003Y	2003	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	5%
38591837T>G	D2009A	2009	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38591836G>C	D2009E	2009	1	0	0	0	1	NA	Non_Hotspot	4%	Non_Hotspot	0%
38591836G>T	D2009E	2009	1	0	0	0	1	NA	Non_Hotspot	4%	Non_Hotspot	0%
38591837T>C	D2009G	2009	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38591838C>G	D2009H	2009	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38591838C>T	D2009N	2009	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38591837T>A	D2009V	2009	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38591838C>A	D2009Y	2009	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38591831T>G	D2011A	2011	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38591830G>C	D2011E	2011	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38591830G>T	D2011E	2011	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38591831T>C	D2011G	2011	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38591832C>G	D2011H	2011	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38591832C>T	D2011N	2011	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38591831T>A	D2011V	2011	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38591832C>A	D2011Y	2011	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38655305T>G	D211A	211	0	0	0	0	0	NA	Mild_Hotspot	19%	Mild_Hotspot	17%
38655304G>C	D211E	211	0	0	0	0	0	NA	Mild_Hotspot	19%	Mild_Hotspot	17%
38655304G>T	D211E	211	0	0	0	0	0	NA	Mild_Hotspot	19%	Mild_Hotspot	17%
38655305T>C	D211G	211	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	18%
38655306C>G	D211H	211	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	18%
38655306C>T	D211N	211	0	0	0	0	0	NA	Mild_Hotspot	18%	Mild_Hotspot	16%
38655305T>A	D211V	211	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	18%
38655306C>A	D211Y	211	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	18%
38651404T>G	D252A	252	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	26%
38651403A>C	D252E	252	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	25%
38651403A>T	D252E	252	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	25%
38651404T>C	D252G	252	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	26%
38651405C>G	D252H	252	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	26%
38651405C>T	D252N	252	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	26%
38651404T>A	D252V	252	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	26%
38651405C>A	D252Y	252	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	26%
38651269T>G	D297A	297	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	2%
38651268G>T	D297E	297	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	2%
38651268G>C	D297E	297	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	2%
38651269T>C	D297G	297	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38651270C>G	D297H	297	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38651270C>T	D297N	297	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	2%
38651269T>A	D297V	297	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38651270C>A	D297Y	297	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38651245T>G	D305A	305	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38651244G>C	D305E	305	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	2%
38651244G>T	D305E	305	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	2%
38651245T>C	D305G	305	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38651246C>G	D305H	305	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38651246C>T	D305N	305	2	0	0	0	2	NA	Non_Hotspot	3%	Non_Hotspot	5%
38651245T>A	D305V	305	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38651246C>A	D305Y	305	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38651230T>G	D310A	310	0	0	0	0	0	NA	Mild_Hotspot	10%	Non_Hotspot	2%
38651229A>C	D310E	310	0	0	0	0	0	NA	Mild_Hotspot	9%	Non_Hotspot	2%
38651229A>T	D310E	310	0	0	0	0	0	NA	Mild_Hotspot	9%	Non_Hotspot	2%
38651230T>C	D310G	310	0	0	0	0	0	NA	Mild_Hotspot	10%	Non_Hotspot	2%
38651231C>G	D310H	310	0	0	0	0	0	NA	Mild_Hotspot	9%	Non_Hotspot	2%
38651231C>T	D310N	310	1	0	0	0	1	NA	Mild_Hotspot	9%	Non_Hotspot	7%
38651230T>A	D310V	310	0	0	0	0	0	NA	Mild_Hotspot	10%	Non_Hotspot	3%
38651231C>A	D310Y	310	0	0	0	0	0	NA	Mild_Hotspot	10%	Non_Hotspot	2%
38649675T>G	D322A	322	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	4%
38649674A>C	D322E	322	0	0	0	0	0	NA	Hotspot	37%	Non_Hotspot	3%
38649674A>T	D322E	322	0	0	0	0	0	NA	Hotspot	37%	Non_Hotspot	3%
38649675T>C	D322G	322	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	4%
38649676C>G	D322H	322	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	4%
38649676C>T	D322N	322	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	4%
38649675T>A	D322V	322	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	4%
38649676C>A	D322Y	322	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	4%
38649648T>G	D331A	331	0	0	0	0	0	NA	Mild_Hotspot	19%	Mild_Hotspot	12%
38649647G>C	D331E	331	0	0	0	0	0	NA	Mild_Hotspot	19%	Mild_Hotspot	11%
38649647G>T	D331E	331	0	0	0	0	0	NA	Mild_Hotspot	19%	Mild_Hotspot	11%
38649648T>C	D331G	331	0	0	0	0	0	NA	Mild_Hotspot	18%	Mild_Hotspot	11%
38649649C>G	D331H	331	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	12%
38649649C>T	D331N	331	0	0	0	0	0	NA	Mild_Hotspot	19%	Mild_Hotspot	11%
38649648T>A	D331V	331	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	12%
38649649C>A	D331Y	331	0	0	0	0	0	NA	Mild_Hotspot	20%	Mild_Hotspot	12%
38648254T>G	D349A	349	0	0	0	0	0	NA	Hotspot	31%	Non_Hotspot	5%
38648253G>C	D349E	349	0	0	0	0	0	NA	Hotspot	30%	Non_Hotspot	4%
38648253G>T	D349E	349	0	0	0	0	0	NA	Hotspot	30%	Non_Hotspot	4%
38648254T>C	D349G	349	0	0	0	0	0	NA	Hotspot	31%	Non_Hotspot	5%
38648255C>G	D349H	349	0	0	0	0	0	NA	Hotspot	30%	Non_Hotspot	4%
38648255C>T	D349N	349	9	0	4	1	5	Partial_LOF	Hotspot	32%	Non_Hotspot	5%
38648254T>A	D349V	349	0	0	0	0	0	NA	Hotspot	31%	Non_Hotspot	5%
38648255C>A	D349Y	349	0	0	0	0	0	NA	Hotspot	30%	Non_Hotspot	4%
38648233T>G	D356A	356	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	10%
38648232A>C	D356E	356	0	0	0	0	0	NA	Hotspot	51%	Non_Hotspot	10%
38648232A>T	D356E	356	0	0	0	0	0	NA	Hotspot	51%	Non_Hotspot	10%
38648233T>C	D356G	356	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	10%
38648234C>G	D356H	356	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	10%
38648234C>T	D356N	356	10	0	9	0	1	LOF	Hotspot	66%	Non_Hotspot	6%
38648233T>A	D356V	356	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	10%
38648234C>A	D356Y	356	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	10%
38648185T>G	D372A	372	0	0	0	0	0	NA	Mild_Hotspot	29%	Mild_Hotspot	25%
38648184G>T	D372E	372	0	0	0	0	0	NA	Mild_Hotspot	28%	Mild_Hotspot	24%
38648184G>C	D372E	372	0	0	0	0	0	NA	Mild_Hotspot	28%	Mild_Hotspot	24%
38648185T>C	D372G	372	0	0	0	0	0	NA	Mild_Hotspot	29%	Mild_Hotspot	25%
38648186C>G	D372H	372	0	0	0	0	0	NA	Mild_Hotspot	29%	Mild_Hotspot	25%
38648186C>T	D372N	372	0	0	0	0	0	NA	Mild_Hotspot	29%	Mild_Hotspot	25%
38648185T>A	D372V	372	0	0	0	0	0	NA	Mild_Hotspot	29%	Mild_Hotspot	25%
38648186C>A	D372Y	372	0	0	0	0	0	NA	Mild_Hotspot	29%	Mild_Hotspot	25%
38646377T>G	D454A	454	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38646376A>C	D454E	454	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38646376A>T	D454E	454	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38646377T>C	D454G	454	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38646378C>G	D454H	454	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38646378C>T	D454N	454	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38646377T>A	D454V	454	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38646378C>A	D454Y	454	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38646263T>G	D492A	492	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38646262G>C	D492E	492	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38646262G>T	D492E	492	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38646263T>C	D492G	492	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38646264C>G	D492H	492	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38646264C>T	D492N	492	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38646263T>A	D492V	492	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38646264C>A	D492Y	492	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38646245T>G	D498A	498	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	3%
38646244G>C	D498E	498	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	2%
38646244G>T	D498E	498	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	2%
38646245T>C	D498G	498	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	3%
38646246C>G	D498H	498	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	3%
38646246C>T	D498N	498	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	3%
38646245T>A	D498V	498	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	3%
38646246C>A	D498Y	498	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38646236T>G	D501A	501	0	0	0	0	0	NA	Hotspot	40%	Non_Hotspot	5%
38646235A>C	D501E	501	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	4%
38646235A>T	D501E	501	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	4%
38646236T>C	D501G	501	1	0	1	1	0	NA	Hotspot	45%	Non_Hotspot	5%
38646237C>G	D501H	501	0	0	0	0	0	NA	Hotspot	40%	Non_Hotspot	5%
38646237C>T	D501N	501	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	4%
38646236T>A	D501V	501	0	0	0	0	0	NA	Hotspot	40%	Non_Hotspot	5%
38646237C>A	D501Y	501	0	0	0	0	0	NA	Hotspot	40%	Non_Hotspot	5%
38645486T>G	D536A	536	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	28%
38645485G>C	D536E	536	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	27%
38645485G>T	D536E	536	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	27%
38645486T>C	D536G	536	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	28%
38645487C>G	D536H	536	2	1	0	0	1	NA	Non_Hotspot	6%	Mild_Hotspot	34%
38645487C>T	D536N	536	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	27%
38645486T>A	D536V	536	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	28%
38645487C>A	D536Y	536	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	28%
38645468T>G	D542A	542	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	5%
38645467A>C	D542E	542	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	5%
38645467A>T	D542E	542	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	5%
38645468T>C	D542G	542	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	5%
38645469C>G	D542H	542	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	5%
38645469C>T	D542N	542	0	0	0	0	0	NA	Hotspot	52%	Non_Hotspot	5%
38645468T>A	D542V	542	0	0	0	0	0	NA	Hotspot	54%	Non_Hotspot	6%
38645469C>A	D542Y	542	0	0	0	0	0	NA	Hotspot	53%	Non_Hotspot	5%
38645459T>G	D545A	545	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	5%
38645458A>C	D545E	545	0	0	0	0	0	NA	Hotspot	47%	Non_Hotspot	4%
38645458A>T	D545E	545	0	0	0	0	0	NA	Hotspot	47%	Non_Hotspot	4%
38645459T>C	D545G	545	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	5%
38645460C>G	D545H	545	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	5%
38645460C>T	D545N	545	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	5%
38645459T>A	D545V	545	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	5%
38645460C>A	D545Y	545	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	5%
38645456T>G	D546A	546	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	5%
38645455A>C	D546E	546	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	4%
38645455A>T	D546E	546	0	0	0	0	0	NA	Hotspot	38%	Non_Hotspot	4%
38645456T>C	D546G	546	0	0	0	1	0	NA	Hotspot	42%	Non_Hotspot	6%
38645457C>G	D546H	546	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	5%
38645457C>T	D546N	546	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	5%
38645456T>A	D546V	546	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	5%
38645457C>A	D546Y	546	0	0	0	0	0	NA	Hotspot	39%	Non_Hotspot	5%
38674629T>G	D57A	57	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	8%
38674628G>C	D57E	57	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	7%
38674628G>T	D57E	57	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	7%
38674629T>C	D57G	57	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	8%
38674630C>G	D57H	57	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	8%
38674630C>T	D57N	57	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	8%
38674629T>A	D57V	57	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	8%
38674630C>A	D57Y	57	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	8%
38645306T>G	D596A	596	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38645305G>C	D596E	596	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38645305G>T	D596E	596	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38645306T>C	D596G	596	1	0	0	0	1	NA	Non_Hotspot	7%	Non_Hotspot	7%
38645307C>G	D596H	596	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38645307C>T	D596N	596	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38645306T>A	D596V	596	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38645307C>A	D596Y	596	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38645270T>G	D608A	608	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38645269G>T	D608E	608	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	3%
38645269G>C	D608E	608	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	3%
38645270T>C	D608G	608	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38645271C>G	D608H	608	1	0	0	0	1	NA	Non_Hotspot	1%	Non_Hotspot	8%
38645271C>T	D608N	608	2	0	0	0	2	NA	Non_Hotspot	8%	Non_Hotspot	8%
38645270T>A	D608V	608	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	3%
38645271C>A	D608Y	608	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38645207T>G	D629A	629	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38645206G>T	D629E	629	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38645206G>C	D629E	629	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38645207T>C	D629G	629	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38645208C>G	D629H	629	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38645208C>T	D629N	629	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38645207T>A	D629V	629	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	5%
38645208C>A	D629Y	629	1	0	0	0	1	NA	Non_Hotspot	4%	Non_Hotspot	9%
38640480T>G	D651A	651	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38640479A>C	D651E	651	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38640479A>T	D651E	651	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38640480T>C	D651G	651	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38640481C>G	D651H	651	1	0	0	0	1	NA	Non_Hotspot	7%	Non_Hotspot	6%
38640481C>T	D651N	651	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38640480T>A	D651V	651	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38640481C>A	D651Y	651	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38674602T>G	D66A	66	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	2%
38674601A>C	D66E	66	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	2%
38674601A>T	D66E	66	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	2%
38674602T>C	D66G	66	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	3%
38674603C>G	D66H	66	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	2%
38674603C>T	D66N	66	1	0	0	0	1	NA	Non_Hotspot	5%	Non_Hotspot	8%
38674602T>A	D66V	66	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	3%
38674603C>A	D66Y	66	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	3%
38639335T>G	D716A	716	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38639334G>C	D716E	716	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38639334G>T	D716E	716	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38639335T>C	D716G	716	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	5%
38639336C>G	D716H	716	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	5%
38639336C>T	D716N	716	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38639335T>A	D716V	716	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	5%
38639336C>A	D716Y	716	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	5%
38639323T>G	D720A	720	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	5%
38639322G>C	D720E	720	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38639322G>T	D720E	720	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38639323T>C	D720G	720	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	5%
38639324C>G	D720H	720	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	5%
38639324C>T	D720N	720	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38639323T>A	D720V	720	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	5%
38639324C>A	D720Y	720	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	5%
0.>.	D757Y	757	0	0	0	1	0	NA	Hotspot	39%	Non_Hotspot	6%
38629012T>G	D772A	772	0	0	0	0	0	NA	Mild_Hotspot	24%	Mild_Hotspot	17%
38629011G>C	D772E	772	0	0	0	0	0	NA	Mild_Hotspot	22%	Mild_Hotspot	16%
38629011G>T	D772E	772	0	0	0	0	0	NA	Mild_Hotspot	22%	Mild_Hotspot	16%
38629012T>C	D772G	772	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	17%
38629013C>G	D772H	772	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	17%
38629013C>T	D772N	772	7	1	1	1	5	Normal	Mild_Hotspot	18%	Mild_Hotspot	17%
38629012T>A	D772V	772	0	0	0	0	0	NA	Mild_Hotspot	24%	Mild_Hotspot	17%
38629013C>A	D772Y	772	0	0	0	0	0	NA	Mild_Hotspot	23%	Mild_Hotspot	17%
38628973T>G	D785A	785	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	5%
38628972G>C	D785E	785	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	4%
38628972G>T	D785E	785	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	4%
38628973T>C	D785G	785	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	5%
38628974C>G	D785H	785	0	0	0	0	0	NA	Hotspot	37%	Non_Hotspot	5%
38628974C>T	D785N	785	2	0	2	0	0	Partial_LOF	Hotspot	43%	Non_Hotspot	3%
38628973T>A	D785V	785	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	5%
38628974C>A	D785Y	785	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	5%
38674554T>G	D82A	82	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38674553G>C	D82E	82	3	0	0	0	3	NA	Non_Hotspot	5%	Non_Hotspot	5%
38674553G>T	D82E	82	3	0	0	0	3	NA	Non_Hotspot	5%	Non_Hotspot	5%
38674554T>C	D82G	82	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38674555C>G	D82H	82	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38674555C>T	D82N	82	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38674554T>A	D82V	82	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38674555C>A	D82Y	82	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	4%
38674548T>G	D84A	84	0	0	0	0	0	NA	Mild_Hotspot	25%	Non_Hotspot	4%
38674547G>C	D84E	84	0	0	0	0	0	NA	Mild_Hotspot	25%	Non_Hotspot	4%
38674547G>T	D84E	84	0	0	0	0	0	NA	Mild_Hotspot	25%	Non_Hotspot	4%
38674548T>C	D84G	84	2	0	0	0	2	NA	Mild_Hotspot	22%	Non_Hotspot	5%
38674549C>G	D84H	84	0	0	0	0	0	NA	Mild_Hotspot	25%	Non_Hotspot	4%
38674549C>T	D84N	84	2	0	2	0	0	Partial_LOF	Mild_Hotspot	33%	Non_Hotspot	4%
38674548T>A	D84V	84	0	0	0	0	0	NA	Mild_Hotspot	26%	Non_Hotspot	4%
38674549C>A	D84Y	84	0	0	0	0	0	NA	Mild_Hotspot	25%	Non_Hotspot	4%
38627360T>G	D870A	870	0	0	0	0	0	NA	Mild_Hotspot	11%	Non_Hotspot	2%
38627359G>C	D870E	870	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	3%
38627359G>T	D870E	870	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	3%
38627360T>C	D870G	870	0	0	0	0	0	NA	Mild_Hotspot	11%	Non_Hotspot	3%
38627361C>G	D870H	870	0	0	0	1	0	NA	Mild_Hotspot	9%	Non_Hotspot	11%
38627361C>T	D870N	870	0	0	0	0	0	NA	Mild_Hotspot	10%	Non_Hotspot	2%
38627360T>A	D870V	870	0	0	0	0	0	NA	Mild_Hotspot	11%	Non_Hotspot	3%
38627361C>A	D870Y	870	0	0	0	0	0	NA	Mild_Hotspot	10%	Non_Hotspot	2%
38627354T>G	D872A	872	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	3%
38627353G>C	D872E	872	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	3%
38627353G>T	D872E	872	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	3%
38627354T>C	D872G	872	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	3%
38627355C>G	D872H	872	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	3%
38627355C>T	D872N	872	4	0	0	0	4	NA	Non_Hotspot	6%	Non_Hotspot	6%
38627354T>A	D872V	872	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	3%
38627355C>A	D872Y	872	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	3%
38627321T>G	D883A	883	0	0	0	0	0	NA	Hotspot	47%	Non_Hotspot	4%
38627320G>C	D883E	883	0	0	0	0	0	NA	Hotspot	45%	Non_Hotspot	4%
38627320G>T	D883E	883	0	0	0	0	0	NA	Hotspot	45%	Non_Hotspot	4%
38627321T>C	D883G	883	0	0	0	0	0	NA	Hotspot	47%	Non_Hotspot	5%
38627322C>G	D883H	883	0	0	0	0	0	NA	Hotspot	46%	Non_Hotspot	4%
38627322C>T	D883N	883	0	0	0	0	0	NA	Hotspot	45%	Non_Hotspot	3%
38627321T>A	D883V	883	0	0	0	0	0	NA	Hotspot	47%	Non_Hotspot	4%
38627322C>A	D883Y	883	0	0	0	0	0	NA	Hotspot	47%	Non_Hotspot	4%
38627255T>G	D905A	905	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	8%
38627254G>C	D905E	905	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	8%
38627254G>T	D905E	905	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	8%
38627255T>C	D905G	905	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	9%
38627256C>G	D905H	905	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	9%
38627256C>T	D905N	905	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	9%
38627255T>A	D905V	905	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	9%
38627256C>A	D905Y	905	0	0	0	0	0	NA	Hotspot	48%	Non_Hotspot	9%
38622816T>G	D945A	945	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	8%
38622815G>C	D945E	945	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	7%
38622815G>T	D945E	945	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	7%
38622816T>C	D945G	945	3	0	0	0	3	NA	Non_Hotspot	5%	Non_Hotspot	5%
38622817C>G	D945H	945	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	8%
38622817C>T	D945N	945	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	8%
38622816T>A	D945V	945	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	8%
38622817C>A	D945Y	945	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	8%
38622798T>G	D951A	951	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	5%
38622797A>C	D951E	951	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38622797A>T	D951E	951	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38622798T>C	D951G	951	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	5%
38622799C>G	D951H	951	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	5%
38622799C>T	D951N	951	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	5%
38622798T>A	D951V	951	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	5%
38622799C>A	D951Y	951	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	5%
38622792T>G	D953A	953	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38622791G>T	D953E	953	2	0	0	0	2	NA	Non_Hotspot	0%	Non_Hotspot	9%
38622791G>C	D953E	953	2	0	0	0	2	NA	Non_Hotspot	0%	Non_Hotspot	9%
38622792T>C	D953G	953	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38622793C>G	D953H	953	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38622793C>T	D953N	953	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38622792T>A	D953V	953	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38622793C>A	D953Y	953	1	0	0	0	1	NA	Non_Hotspot	5%	Non_Hotspot	8%
38622714T>G	D979A	979	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	9%
38622713A>C	D979E	979	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	9%
38622713A>T	D979E	979	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	9%
38622714T>C	D979G	979	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	9%
38622715C>G	D979H	979	1	0	0	0	1	NA	Non_Hotspot	7%	Non_Hotspot	11%
38622715C>T	D979N	979	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	8%
38622714T>A	D979V	979	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	10%
38622715C>A	D979Y	979	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	10%
38622606T>G	E1015A	1015	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38622605C>A	E1015D	1015	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38622605C>G	E1015D	1015	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38622606T>C	E1015G	1015	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	3%
38622607C>T	E1015K	1015	1	0	0	0	1	NA	Mild_Hotspot	14%	Non_Hotspot	0%
38622607C>G	E1015Q	1015	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38622606T>A	E1015V	1015	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	4%
38622600T>G	E1017A	1017	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38622599C>A	E1017D	1017	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38622599C>G	E1017D	1017	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38622600T>C	E1017G	1017	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38622601C>T	E1017K	1017	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38622601C>G	E1017Q	1017	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38622600T>A	E1017V	1017	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	5%
38622576T>G	E1025A	1025	1	0	0	0	1	NA	Non_Hotspot	6%	Non_Hotspot	2%
38622575T>G	E1025D	1025	0	0	0	1	0	GOF	Non_Hotspot	5%	Non_Hotspot	6%
38622575T>A	E1025D	1025	0	0	0	1	0	GOF	Non_Hotspot	5%	Non_Hotspot	6%
38622576T>C	E1025G	1025	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38622577C>T	E1025K	1025	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38622577C>G	E1025Q	1025	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38622576T>A	E1025V	1025	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38622564T>G	E1029A	1029	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38622563C>A	E1029D	1029	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38622563C>G	E1029D	1029	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38622564T>C	E1029G	1029	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38622565C>T	E1029K	1029	1	0	0	0	1	NA	Non_Hotspot	7%	Non_Hotspot	5%
38622565C>G	E1029Q	1029	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38622564T>A	E1029V	1029	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38622561T>G	E1030A	1030	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38622560T>A	E1030D	1030	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38622560T>G	E1030D	1030	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38622561T>C	E1030G	1030	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38622562C>T	E1030K	1030	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	5%
38622562C>G	E1030Q	1030	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	5%
38622561T>A	E1030V	1030	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	5%
38622555T>G	E1032A	1032	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	4%
38622554C>G	E1032D	1032	1	0	0	0	1	NA	Non_Hotspot	4%	Non_Hotspot	4%
38622554C>A	E1032D	1032	1	0	0	0	1	NA	Non_Hotspot	4%	Non_Hotspot	4%
38622555T>C	E1032G	1032	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	5%
38622556C>T	E1032K	1032	15	1	0	0	14	NA	Non_Hotspot	3%	Non_Hotspot	5%
38622556C>G	E1032Q	1032	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	5%
38622555T>A	E1032V	1032	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	5%
38622522T>G	E1043A	1043	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622521C>A	E1043D	1043	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622521C>G	E1043D	1043	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622522T>C	E1043G	1043	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38622523C>T	E1043K	1043	1	0	0	0	1	NA	Non_Hotspot	5%	Non_Hotspot	7%
38622523C>G	E1043Q	1043	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38622522T>A	E1043V	1043	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622492T>G	E1053A	1053	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	6%
38622491C>A	E1053D	1053	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	5%
38622491C>G	E1053D	1053	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	5%
38622492T>C	E1053G	1053	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	6%
38622493C>T	E1053K	1053	40	2	5	1	33	Normal	Mild_Hotspot	13%	Non_Hotspot	5%
38622493C>G	E1053Q	1053	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	5%
38622492T>A	E1053V	1053	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	6%
38622471T>G	E1060A	1060	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38622470T>A	E1060D	1060	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38622470T>G	E1060D	1060	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38622471T>C	E1060G	1060	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38622472C>T	E1060K	1060	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38622472C>G	E1060Q	1060	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	3%
38622471T>A	E1060V	1060	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	4%
38622468T>G	E1061A	1061	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622467T>A	E1061D	1061	3	0	0	0	3	NA	Non_Hotspot	1%	Non_Hotspot	1%
38622467T>G	E1061D	1061	3	0	0	0	3	NA	Non_Hotspot	1%	Non_Hotspot	1%
38622468T>C	E1061G	1061	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622469C>T	E1061K	1061	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622469C>G	E1061Q	1061	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622468T>A	E1061V	1061	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622462T>G	E1063A	1063	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38622461C>A	E1063D	1063	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38622461C>G	E1063D	1063	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38622462T>C	E1063G	1063	1	0	0	0	1	NA	Non_Hotspot	5%	Non_Hotspot	1%
38622463C>T	E1063K	1063	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38622463C>G	E1063Q	1063	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38622462T>A	E1063V	1063	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38622459T>G	E1064A	1064	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38622458C>A	E1064D	1064	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38622458C>G	E1064D	1064	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38622459T>C	E1064G	1064	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38622460C>T	E1064K	1064	0	0	0	1	0	NA	Non_Hotspot	1%	Non_Hotspot	5%
38622460C>G	E1064Q	1064	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38622459T>A	E1064V	1064	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38622441T>G	E1070A	1070	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	12%
38622440C>A	E1070D	1070	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	11%
38622440C>G	E1070D	1070	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	11%
38622441T>C	E1070G	1070	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	12%
38622442C>T	E1070K	1070	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	12%
38622442C>G	E1070Q	1070	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	11%
38622441T>A	E1070V	1070	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	12%
38622438T>G	E1071A	1071	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	11%
38622437C>A	E1071D	1071	0	0	0	0	0	NA	Non_Hotspot	3%	Mild_Hotspot	11%
38622437C>G	E1071D	1071	0	0	0	0	0	NA	Non_Hotspot	3%	Mild_Hotspot	11%
38622438T>C	E1071G	1071	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	11%
38622439C>T	E1071K	1071	3	0	0	0	3	NA	Non_Hotspot	4%	Mild_Hotspot	15%
38622439C>G	E1071Q	1071	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	11%
38622438T>A	E1071V	1071	0	0	0	0	0	NA	Non_Hotspot	3%	Mild_Hotspot	11%
38622435T>G	E1072A	1072	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	18%
38622434C>A	E1072D	1072	0	0	0	0	0	NA	Non_Hotspot	3%	Mild_Hotspot	17%
38622434C>G	E1072D	1072	0	0	0	0	0	NA	Non_Hotspot	3%	Mild_Hotspot	17%
38622435T>C	E1072G	1072	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	18%
38622436C>T	E1072K	1072	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	18%
38622436C>G	E1072Q	1072	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	18%
38622435T>A	E1072V	1072	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	19%
38620982T>G	E1078A	1078	0	0	0	0	0	NA	Mild_Hotspot	18%	Mild_Hotspot	19%
38620981T>A	E1078D	1078	0	0	0	0	0	NA	Mild_Hotspot	17%	Mild_Hotspot	19%
38620981T>G	E1078D	1078	0	0	0	0	0	NA	Mild_Hotspot	17%	Mild_Hotspot	19%
38620982T>C	E1078G	1078	0	0	0	0	0	NA	Mild_Hotspot	18%	Mild_Hotspot	19%
38620983C>T	E1078K	1078	0	0	0	0	0	NA	Mild_Hotspot	17%	Mild_Hotspot	19%
38620983C>G	E1078Q	1078	0	0	0	0	0	NA	Mild_Hotspot	17%	Mild_Hotspot	19%
38620982T>A	E1078V	1078	0	0	0	0	0	NA	Mild_Hotspot	18%	Mild_Hotspot	19%
38620955T>G	E1087A	1087	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38620954C>A	E1087D	1087	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620954C>G	E1087D	1087	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620955T>C	E1087G	1087	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38620956C>T	E1087K	1087	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38620956C>G	E1087Q	1087	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620955T>A	E1087V	1087	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38620901T>G	E1105A	1105	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620900C>A	E1105D	1105	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620900C>G	E1105D	1105	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620901T>C	E1105G	1105	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38620902C>T	E1105K	1105	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620902C>G	E1105Q	1105	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620901T>A	E1105V	1105	1	0	0	0	1	NA	Non_Hotspot	6%	Non_Hotspot	1%
38620895T>G	E1107A	1107	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620894C>A	E1107D	1107	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620894C>G	E1107D	1107	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620895T>C	E1107G	1107	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	3%
38620896C>T	E1107K	1107	34	0	0	1	34	NA	Non_Hotspot	1%	Non_Hotspot	1%
38620896C>G	E1107Q	1107	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620895T>A	E1107V	1107	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38620850T>G	E1122A	1122	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38620849T>A	E1122D	1122	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38620849T>G	E1122D	1122	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38620850T>C	E1122G	1122	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38620851C>T	E1122K	1122	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38620851C>G	E1122Q	1122	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	4%
38620850T>A	E1122V	1122	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38620826T>G	E1130A	1130	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38620825C>A	E1130D	1130	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38620825C>G	E1130D	1130	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38620826T>C	E1130G	1130	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38620827C>T	E1130K	1130	1	0	0	0	1	NA	Non_Hotspot	2%	Non_Hotspot	8%
38620827C>G	E1130Q	1130	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38620826T>A	E1130V	1130	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38618265T>G	E1133A	1133	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38618264C>A	E1133D	1133	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38618264C>G	E1133D	1133	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38618265T>C	E1133G	1133	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38618266C>T	E1133K	1133	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38618266C>G	E1133Q	1133	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38618265T>A	E1133V	1133	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38618250T>G	E1138A	1138	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	5%
38618249C>A	E1138D	1138	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	5%
38618249C>G	E1138D	1138	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	5%
38618250T>C	E1138G	1138	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	5%
38618251C>T	E1138K	1138	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	5%
38618251C>G	E1138Q	1138	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	5%
38618250T>A	E1138V	1138	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	5%
38618217T>G	E1149A	1149	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38618216C>A	E1149D	1149	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38618216C>G	E1149D	1149	0	0	0	0	0	NA	Non_Hotspot	3%	Non_Hotspot	2%
38618217T>C	E1149G	1149	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	2%
38618218C>T	E1149K	1149	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38618218C>G	E1149Q	1149	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38618217T>A	E1149V	1149	0	0	0	0	0	NA	Non_Hotspot	4%	Non_Hotspot	3%
38618208T>G	E1152A	1152	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38618207C>A	E1152D	1152	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38618207C>G	E1152D	1152	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38618208T>C	E1152G	1152	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	4%
38618209C>T	E1152K	1152	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38618209C>G	E1152Q	1152	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	3%
38618208T>A	E1152V	1152	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	4%
38618169T>G	E1165A	1165	0	0	0	0	0	NA	Non_Hotspot	4%	Mild_Hotspot	10%
38618168C>G	E1165D	1165	1	0	0	0	1	NA	Non_Hotspot	10%	Mild_Hotspot	11%
38618168C>A	E1165D	1165	1	0	0	0	1	NA	Non_Hotspot	10%	Mild_Hotspot	11%
38618169T>C	E1165G	1165	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	10%
38618170C>T	E1165K	1165	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	11%
38618170C>G	E1165Q	1165	1	0	0	0	1	NA	Non_Hotspot	3%	Mild_Hotspot	10%
38618169T>A	E1165V	1165	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	10%
38618154T>G	E1170A	1170	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	7%
38618153T>A	E1170D	1170	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	7%
38618153T>G	E1170D	1170	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	7%
38618154T>C	E1170G	1170	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	7%
38618155C>T	E1170K	1170	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	7%
38618155C>G	E1170Q	1170	0	0	0	0	0	NA	Non_Hotspot	5%	Non_Hotspot	7%
38618154T>A	E1170V	1170	0	0	0	0	0	NA	Non_Hotspot	6%	Non_Hotspot	8%
38616846T>G	E1203A	1203	0	0	0	0	0	NA	Mild_Hotspot	13%	Mild_Hotspot	11%
38616845C>A	E1203D	1203	0	0	0	0	0	NA	Mild_Hotspot	12%	Mild_Hotspot	11%
38616845C>G	E1203D	1203	0	0	0	0	0	NA	Mild_Hotspot	12%	Mild_Hotspot	11%
38616846T>C	E1203G	1203	0	0	0	0	0	NA	Mild_Hotspot	13%	Mild_Hotspot	11%
38616847C>T	E1203K	1203	0	0	0	0	0	NA	Mild_Hotspot	13%	Mild_Hotspot	11%
38616847C>G	E1203Q	1203	0	0	0	0	0	NA	Mild_Hotspot	13%	Mild_Hotspot	11%
38616846T>A	E1203V	1203	0	0	0	0	0	NA	Mild_Hotspot	13%	Mild_Hotspot	11%
38616831T>G	E1208A	1208	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	26%
38616830C>A	E1208D	1208	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	26%
38616830C>G	E1208D	1208	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	26%
38616831T>C	E1208G	1208	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	26%
38616832C>T	E1208K	1208	4	1	0	0	3	Normal	Non_Hotspot	6%	Mild_Hotspot	26%
38616832C>G	E1208Q	1208	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	26%
38616831T>A	E1208V	1208	0	0	0	0	0	NA	Non_Hotspot	8%	Mild_Hotspot	26%
38608066T>G	E1225A	1225	0	0	0	0	0	NA	Hotspot	51%	Non_Hotspot	8%
38608065C>A	E1225D	1225	0	0	0	0	0	NA	Hotspot	49%	Non_Hotspot	7%
38608065C>G	E1225D	1225	0	0	0	0	0	NA	Hotspot	49%	Non_Hotspot	7%
38608066T>C	E1225G	1225	0	0	0	0	0	NA	Hotspot	51%	Non_Hotspot	8%
38608067C>T	E1225K	1225	14	1	11	0	2	Partial_LOF	Hotspot	62%	Non_Hotspot	7%
38608067C>G	E1225Q	1225	0	0	0	0	0	NA	Hotspot	51%	Non_Hotspot	8%
38608066T>A	E1225V	1225	0	0	0	0	0	NA	Hotspot	51%	Non_Hotspot	8%
38608051T>G	E1230A	1230	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	6%
38608050C>A	E1230D	1230	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	5%
38608050C>G	E1230D	1230	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	5%
38608051T>C	E1230G	1230	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	6%
38608052C>T	E1230K	1230	5	0	0	0	5	NA	Mild_Hotspot	13%	Non_Hotspot	3%
38608052C>G	E1230Q	1230	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	6%
38608051T>A	E1230V	1230	0	0	0	0	0	NA	Mild_Hotspot	15%	Non_Hotspot	6%
38608048T>G	E1231A	1231	0	0	0	0	0	NA	Mild_Hotspot	17%	Mild_Hotspot	10%
38608047C>A	E1231D	1231	0	0	0	0	0	NA	Mild_Hotspot	16%	Mild_Hotspot	10%
38608047C>G	E1231D	1231	0	0	0	0	0	NA	Mild_Hotspot	16%	Mild_Hotspot	10%
38608048T>C	E1231G	1231	0	0	0	0	0	NA	Mild_Hotspot	17%	Mild_Hotspot	10%
38608049C>T	E1231K	1231	4	1	0	0	3	NA	Mild_Hotspot	14%	Mild_Hotspot	10%
38608049C>G	E1231Q	1231	0	0	0	0	0	NA	Mild_Hotspot	17%	Mild_Hotspot	10%
38608048T>A	E1231V	1231	0	0	0	0	0	NA	Mild_Hotspot	17%	Mild_Hotspot	10%
38608021T>G	E1240A	1240	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	4%
38608020C>A	E1240D	1240	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	3%
38608020C>G	E1240D	1240	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	3%
38608021T>C	E1240G	1240	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	4%
38608022C>T	E1240K	1240	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	4%
38608022C>G	E1240Q	1240	11	0	1	0	10	NA	Mild_Hotspot	16%	Non_Hotspot	2%
38608021T>A	E1240V	1240	0	0	0	0	0	NA	Mild_Hotspot	19%	Non_Hotspot	4%
38607982T>G	E1253A	1253	0	0	0	0	0	NA	Hotspot	51%	Non_Hotspot	4%
38607981C>A	E1253D	1253	0	0	0	0	0	NA	Hotspot	51%	Non_Hotspot	4%
38607981C>G	E1253D	1253	0	0	0	0	0	NA	Hotspot	51%	Non_Hotspot	4%
38607982T>C	E1253G	1253	1	0	1	0	0	NA	Hotspot	54%	Non_Hotspot	4%
38607983C>T	E1253K	1253	0	0	0	0	0	NA	Hotspot	51%	Non_Hotspot	4%
38607983C>G	E1253Q	1253	0	0	0	0	0	NA	Hotspot	51%	Non_Hotspot	4%
38607982T>A	E1253V	1253	0	0	0	0	0	NA	Hotspot	51%	Non_Hotspot	4%
38603985T>G	E1295A	1295	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	22%
38603984C>A	E1295D	1295	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	21%
38603984C>G	E1295D	1295	0	0	0	0	0	NA	Non_Hotspot	5%	Mild_Hotspot	21%
38603985T>C	E1295G	1295	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	22%
38603986C>T	E1295K	1295	2	1	0	0	1	Normal	Non_Hotspot	6%	Mild_Hotspot	24%
38603986C>G	E1295Q	1295	0	0	0	0	0	NA	Non_Hotspot	6%	Mild_Hotspot	21%
38603985T>A	E1295V	1295	0	0	0	0	0	NA	Non_Hotspot	7%	Mild_Hotspot	22%
38603916T>G	E1318A	1318	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	6%
38603915C>A	E1318D	1318	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	5%
38603915C>G	E1318D	1318	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	5%
38603916T>C	E1318G	1318	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	6%
38603917C>T	E1318K	1318	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	6%
38603917C>G	E1318Q	1318	0	0	0	0	0	NA	Mild_Hotspot	12%	Non_Hotspot	5%
38603916T>A	E1318V	1318	0	0	0	0	0	NA	Mild_Hotspot	13%	Non_Hotspot	6%
38601780T>G	E1368A	1368	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	3%
38601779C>A	E1368D	1368	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	3%
38601779C>G	E1368D	1368	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	3%
38601780T>C	E1368G	1368	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	3%
38601781C>T	E1368K	1368	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	3%
38601781C>G	E1368Q	1368	0	0	0	0	0	NA	Non_Hotspot	10%	Non_Hotspot	3%
38601780T>A	E1368V	1368	0	0	0	0	0	NA	Non_Hotspot	11%	Non_Hotspot	3%
38601729T>G	E1385A	1385	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	3%
38601728C>A	E1385D	1385	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	3%
38601728C>G	E1385D	1385	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	3%
38601729T>C	E1385G	1385	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	3%
38601730C>T	E1385K	1385	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	3%
38601730C>G	E1385Q	1385	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	3%
38601729T>A	E1385V	1385	0	0	0	0	0	NA	Mild_Hotspot	14%	Non_Hotspot	3%
38601708T>G	E1392A	1392	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38601707T>G	E1392D	1392	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38601707T>A	E1392D	1392	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38601708T>C	E1392G	1392	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38601709C>T	E1392K	1392	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38601709C>G	E1392Q	1392	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38601708T>A	E1392V	1392	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	3%
38598065T>G	E1435A	1435	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	7%
38598064T>G	E1435D	1435	0	0	0	0	0	NA	Hotspot	35%	Non_Hotspot	6%
38598064T>A	E1435D	1435	0	0	0	0	0	NA	Hotspot	35%	Non_Hotspot	6%
38598065T>C	E1435G	1435	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	6%
38598066C>T	E1435K	1435	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	6%
38598066C>G	E1435Q	1435	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	6%
38598065T>A	E1435V	1435	0	0	0	0	0	NA	Hotspot	37%	Non_Hotspot	7%
38598062T>G	E1436A	1436	0	0	0	0	0	NA	Hotspot	33%	Non_Hotspot	5%
38598061C>A	E1436D	1436	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	5%
38598061C>G	E1436D	1436	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	5%
38598062T>C	E1436G	1436	0	0	0	0	0	NA	Hotspot	33%	Non_Hotspot	5%
38598063C>T	E1436K	1436	0	0	0	0	0	NA	Hotspot	33%	Non_Hotspot	5%
38598063C>G	E1436Q	1436	0	0	0	0	0	NA	Hotspot	32%	Non_Hotspot	5%
38598062T>A	E1436V	1436	0	0	0	0	0	NA	Hotspot	34%	Non_Hotspot	5%
38598047T>G	E1441A	1441	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	4%
38598046T>G	E1441D	1441	0	0	0	0	0	NA	Hotspot	35%	Non_Hotspot	3%
38598046T>A	E1441D	1441	0	0	0	0	0	NA	Hotspot	35%	Non_Hotspot	3%
38598047T>C	E1441G	1441	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	4%
38598048C>T	E1441K	1441	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	4%
38598048C>G	E1441Q	1441	1	0	1	0	0	NA	Hotspot	40%	Non_Hotspot	1%
38598047T>A	E1441V	1441	0	0	0	0	0	NA	Hotspot	36%	Non_Hotspot	4%
38597223T>G	E1489A	1489	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	43%
38597222C>A	E1489D	1489	2	1	0	0	1	NA	Non_Hotspot	5%	Hotspot	41%
38597222C>G	E1489D	1489	2	1	0	0	1	NA	Non_Hotspot	5%	Hotspot	41%
38597223T>C	E1489G	1489	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	43%
38597224C>T	E1489K	1489	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	43%
38597224C>G	E1489Q	1489	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	43%
38597223T>A	E1489V	1489	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	43%
38597220T>G	E1490A	1490	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	49%
38597219C>G	E1490D	1490	0	0	0	0	0	NA	Non_Hotspot	6%	Hotspot	48%
38597219C>A	E1490D	1490	0	0	0	0	0	NA	Non_Hotspot	6%	Hotspot	48%
38597220T>C	E1490G	1490	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	49%
38597221C>T	E1490K	1490	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	49%
38597221C>G	E1490Q	1490	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	49%
38597220T>A	E1490V	1490	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	49%
38595940T>G	E1548A	1548	0	0	0	0	0	NA	Hotspot	41%	Non_Hotspot	5%
38595939C>A	E1548D	1548	0	0	0	0	0	NA	Hotspot	40%	Non_Hotspot	4%
38595939C>G	E1548D	1548	0	0	0	0	0	NA	Hotspot	40%	Non_Hotspot	4%
38595940T>C	E1548G	1548	0	0	0	0	0	NA	Hotspot	41%	Non_Hotspot	5%
38595941C>T	E1548K	1548	4	0	3	0	1	NA	Hotspot	47%	Non_Hotspot	3%
38595941C>G	E1548Q	1548	0	0	0	0	0	NA	Hotspot	41%	Non_Hotspot	5%
38595940T>A	E1548V	1548	0	0	0	0	0	NA	Hotspot	41%	Non_Hotspot	5%
38595919T>G	E1555A	1555	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	4%
38595918C>A	E1555D	1555	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	4%
38595918C>G	E1555D	1555	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	4%
38595919T>C	E1555G	1555	0	0	0	0	0	NA	Mild_Hotspot	17%	Non_Hotspot	4%
38595920C>T	E1555K	1555	1	0	0	0	1	NA	Mild_Hotspot	19%	Non_Hotspot	0%
38595920C>G	E1555Q	1555	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	4%
38595919T>A	E1555V	1555	0	0	0	0	0	NA	Mild_Hotspot	18%	Non_Hotspot	4%
38595862T>G	E1574A	1574	0	0	0	0	0	NA	Hotspot	45%	Non_Hotspot	4%
38595861C>A	E1574D	1574	0	0	0	0	0	NA	Hotspot	44%	Non_Hotspot	4%
38595861C>G	E1574D	1574	0	0	0	0	0	NA	Hotspot	44%	Non_Hotspot	4%
38595862T>C	E1574G	1574	0	0	0	0	0	NA	Hotspot	45%	Non_Hotspot	4%
38595863C>T	E1574K	1574	4	0	4	0	0	Partial_LOF	Hotspot	54%	Non_Hotspot	1%
38595863C>G	E1574Q	1574	0	0	0	0	0	NA	Hotspot	45%	Non_Hotspot	4%
38595862T>A	E1574V	1574	0	0	0	0	0	NA	Hotspot	45%	Non_Hotspot	4%
38663891T>G	E161A	161	0	0	0	0	0	NA	Hotspot	42%	Non_Hotspot	6%
38662462C>G	E161D	161	0	0	0	0	0	NA	Hotspot	41%	Non_Hotspot	5%
38662462C>A	E161D	161	0	0	0	0	0	NA	Hotspot	41%	Non_Hotspot	5%
38663891T>C	E161G	161	0	0	0	0	0	NA	Hotspot	42%	Non_Hotspot	6%
38663892C>T	E161K	161	13	1	11	2	1	Partial_LOF	Hotspot	60%	Non_Hotspot	5%
38663892C>G	E161Q	161	1	0	1	0	0	NA	Hotspot	46%	Non_Hotspot	2%
38663891T>A	E161V	161	0	0	0	0	0	NA	Hotspot	42%	Non_Hotspot	6%
38592809T>G	E1685A	1685	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38592808C>A	E1685D	1685	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38592808C>G	E1685D	1685	0	0	0	0	0	NA	Non_Hotspot	7%	Non_Hotspot	3%
38592809T>C	E1685G	1685	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38592810C>T	E1685K	1685	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	4%
38592810C>G	E1685Q	1685	0	0	0	0	0	NA	Non_Hotspot	8%	Non_Hotspot	3%
38592809T>A	E1685V	1685	0	0	0	0	0	NA	Non_Hotspot	9%	Non_Hotspot	4%
38662433T>G	E171A	171	0	0	0	0	0	NA	Mild_Hotspot	21%	Non_Hotspot	4%
38662432C>A	E171D	171	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	4%
38662432C>G	E171D	171	0	0	0	0	0	NA	Mild_Hotspot	20%	Non_Hotspot	4%
38662433T>C	E171G	171	0	0	0	0	0	NA	Mild_Hotspot	21%	Non_Hotspot	4%
38662434C>T	E171K	171	0	0	0	0	0	NA	Mild_Hotspot	21%	Non_Hotspot	4%
38662434C>G	E171Q	171	0	0	0	0	0	NA	Mild_Hotspot	21%	Non_Hotspot	4%
38662433T>A	E171V	171	0	0	0	0	0	NA	Mild_Hotspot	21%	Non_Hotspot	4%
38592545T>G	E1773A	1773	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	44%
38592544C>A	E1773D	1773	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	44%
38592544C>G	E1773D	1773	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	44%
38592545T>C	E1773G	1773	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	44%
38592546C>T	E1773K	1773	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	44%
38592546C>G	E1773Q	1773	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	44%
38592545T>A	E1773V	1773	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	44%
38592524T>G	E1780A	1780	0	0	0	0	0	NA	Hotspot	31%	Mild_Hotspot	20%
38592523C>A	E1780D	1780	0	0	0	0	0	NA	Hotspot	30%	Mild_Hotspot	19%
38592523C>G	E1780D	1780	0	0	0	0	0	NA	Hotspot	30%	Mild_Hotspot	19%
38592524T>C	E1780G	1780	1	0	1	1	0	GOF	Hotspot	34%	Mild_Hotspot	20%
38592525C>T	E1780K	1780	0	0	0	0	0	NA	Hotspot	31%	Mild_Hotspot	20%
38592525C>G	E1780Q	1780	0	0	0	0	0	NA	Hotspot	30%	Mild_Hotspot	20%
38592524T>A	E1780V	1780	0	0	0	0	0	NA	Hotspot	31%	Mild_Hotspot	20%
38592521T>G	E1781A	1781	0	0	0	0	0	NA	Non_Hotspot	11%	Mild_Hotspot	26%
38592520C>G	E1781D	1781	1	0	0	0	1	NA	Non_Hotspot	5%	Mild_Hotspot	28%
38592520C>A	E1781D	1781	1	0	0	0	1	NA	Non_Hotspot	5%	Mild_Hotspot	28%
38592521T>C	E1781G	1781	3	3	0	0	0	NA	Non_Hotspot	9%	Mild_Hotspot	37%
38592522C>T	E1781K	1781	0	0	0	0	0	NA	Non_Hotspot	11%	Mild_Hotspot	26%
38592522C>G	E1781Q	1781	0	0	0	0	0	NA	Non_Hotspot	10%	Mild_Hotspot	25%
38592521T>A	E1781V	1781	0	0	0	0	0	NA	Non_Hotspot	11%	Mild_Hotspot	26%
38592512T>G	E1784A	1784	0	0	0	0	0	NA	Mild_Hotspot	14%	Hotspot	44%
38592511C>A	E1784D	1784	0	0	0	0	0	NA	Mild_Hotspot	13%	Hotspot	43%
38592511C>G	E1784D	1784	0	0	0	0	0	NA	Mild_Hotspot	13%	Hotspot	43%
38592512T>C	E1784G	1784	0	0	0	0	0	NA	Mild_Hotspot	14%	Hotspot	44%
38592513C>T	E1784K	1784	164	114	31	2	19	GOF	Mild_Hotspot	18%	Hotspot	67%
38592513C>G	E1784Q	1784	0	0	0	0	0	NA	Mild_Hotspot	14%	Hotspot	43%
38592512T>A	E1784V	1784	0	0	0	0	0	NA	Mild_Hotspot	14%	Hotspot	44%
38592500T>G	E1788A	1788	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	35%
38592499C>A	E1788D	1788	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	34%
38592499C>G	E1788D	1788	0	0	0	0	0	NA	Non_Hotspot	7%	Hotspot	34%
38592500T>C	E1788G	1788	0	0	0	0	0	NA	Non_Hotspot	8%	Hotspot	35%
38592501C>T	E1788K	1788	0	0	0	0	0	NA	Non_Hotspot