A887P Summary

SCN5A A887P was found in 0 papers (see below) with a total of 0 carriers: 0 had BrS1, 0 had LQT3, and 0 had other disease. A887P is not present in gnomAD. A887P has been functionally characterized in 0 papers. Other variants at the same resdue are A887D .A887G .A887P .A887S .A887T .A887V . This residue is located in a Hotspot region for BrS1 and in a Non_Hotspot region for Long QT syndrome.

A887P Predictions

PROVEAN scores less than -2 are considered deleterious. REVEL scores higher than 0.5 or 0.75 is considered likely pathogenic (higher sensitivity with the former cutoff, higher specificity with the latter cutoff). A PolyPhen-2 score of 0.85 or greater is considered likely pathogenic. PAM scores reflect the chemistry difference between WT and variant amino acid (more negative being greater difference between the two). BLAST-PSSM reflects the evolutionary conservation of residue substitutions, more negative numbers indicate fewer observations of the specific substitution than is expected.

SIFT Sift Score PROVEAN Score Polyphen2 Polyphen2 Score eaRate blastPssm pamScore REVEL
NA NA NA NA NA NA NA NA 0.896

A887P has 66 neighbors within 15 ångströms that have been found in individuals.

A residue within a folded protein on average has nearest neighbors that fall roughly into two shells: a "nearest" neighbor around 5-6 angstroms and a second shell around 11 angstroms.

ResidueNumber Distance(Å) Variants
145 14.3
148 12.4
149 11.1
150 14.7
151 13.3
152 11 D152N
220 14 T220I
223 13.3 V223L
846 14.4
847 12.7
848 14.2 I848F
849 13.2
850 8.9 V850M
851 9.4 F851L F851L F851L
852 11
853 9.4
854 4.8
855 7.6
856 9.3
857 6.9 G857D
858 6.4 M858L M858L
859 11.4
860 11.6
861 10
862 9.8
863 14.4
864 13.9
865 10.6
876 13.2
877 11.7
878 13.1 R878C R878H
879 9.2 W879R W879R
880 7.4
881 5.2
882 8.9
883 6.4
884 5.3
885 7.2
886 5.4 H886P H886Q H886Q
888 5.4
889 5.8
890 4.8 I890T
891 6.1
892 9.4 F892I
893 10.6 R893C R893H
894 10.4
895 12.3
896 13.9
898 14.2
901 14.2 E901K
902 10.4
903 14.4
905 13.5
906 12
915 13.2
918 12.3
919 11.1
922 12
1422 13.7
1425 13.7
1440 14.6
1441 14.5
1444 11.3
1447 10.5
1448 13.7 I1448L
1451 13.4