A887T Summary
SCN5A A887T was found in 0 papers (see below) with a total of 0 carriers: 0 had BrS1, 0 had LQT3, and 0 had other disease. A887T is not present in gnomAD. A887T has been functionally characterized in 0 papers. Other variants at the same resdue are A887D .A887G .A887P .A887S .A887T .A887V .
This residue is located in a Hotspot region for BrS1 and in a Non_Hotspot region for Long QT syndrome.
A887T Predictions
PROVEAN scores less than -2 are considered deleterious. REVEL scores higher than 0.5 or 0.75 is considered likely pathogenic (higher sensitivity with the former cutoff, higher specificity with the latter cutoff). A PolyPhen-2 score of 0.85 or greater is considered likely pathogenic. PAM scores reflect the chemistry difference between WT and variant amino acid (more negative being greater difference between the two). BLAST-PSSM reflects the evolutionary conservation of residue substitutions, more negative numbers indicate fewer observations of the specific substitution than is expected.
SIFT |
Sift Score |
PROVEAN Score |
Polyphen2 |
Polyphen2 Score |
eaRate |
blastPssm |
pamScore |
REVEL |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
0.753 |
A887T has 66 neighbors within 15 ångströms that have been found in individuals.
A residue within a folded protein on average has nearest neighbors that fall roughly into two shells: a "nearest" neighbor around 5-6 angstroms and a second shell around 11 angstroms.
ResidueNumber |
Distance(Å) |
Variants |
145 |
14.3 |
|
148 |
12.4 |
|
149 |
11.1 |
|
150 |
14.7 |
|
151 |
13.3 |
|
152 |
11 |
D152N |
220 |
14 |
T220I |
223 |
13.3 |
V223L |
846 |
14.4 |
|
847 |
12.7 |
|
848 |
14.2 |
I848F |
849 |
13.2 |
|
850 |
8.9 |
V850M |
851 |
9.4 |
F851L F851L F851L |
852 |
11 |
|
853 |
9.4 |
|
854 |
4.8 |
|
855 |
7.6 |
|
856 |
9.3 |
|
857 |
6.9 |
G857D |
858 |
6.4 |
M858L M858L |
859 |
11.4 |
|
860 |
11.6 |
|
861 |
10 |
|
862 |
9.8 |
|
863 |
14.4 |
|
864 |
13.9 |
|
865 |
10.6 |
|
876 |
13.2 |
|
877 |
11.7 |
|
878 |
13.1 |
R878C R878H |
879 |
9.2 |
W879R W879R |
880 |
7.4 |
|
881 |
5.2 |
|
882 |
8.9 |
|
883 |
6.4 |
|
884 |
5.3 |
|
885 |
7.2 |
|
886 |
5.4 |
H886P H886Q H886Q |
888 |
5.4 |
|
889 |
5.8 |
|
890 |
4.8 |
I890T |
891 |
6.1 |
|
892 |
9.4 |
F892I |
893 |
10.6 |
R893C R893H |
894 |
10.4 |
|
895 |
12.3 |
|
896 |
13.9 |
|
898 |
14.2 |
|
901 |
14.2 |
E901K |
902 |
10.4 |
|
903 |
14.4 |
|
905 |
13.5 |
|
906 |
12 |
|
915 |
13.2 |
|
918 |
12.3 |
|
919 |
11.1 |
|
922 |
12 |
|
1422 |
13.7 |
|
1425 |
13.7 |
|
1440 |
14.6 |
|
1441 |
14.5 |
|
1444 |
11.3 |
|
1447 |
10.5 |
|
1448 |
13.7 |
I1448L |
1451 |
13.4 |
|