F355Y Summary

SCN5A F355Y was found in 0 papers (see below) with a total of 0 carriers: 0 had BrS1, 0 had LQT3, and 0 had other disease. F355Y is not present in gnomAD. F355Y has been functionally characterized in 0 papers. Other variants at the same resdue are F355C .F355I .F355L .F355L .F355L .F355S .F355V .F355Y . This residue is located in a Hotspot region for BrS1 and in a Mild_Hotspot region for Long QT syndrome.

F355Y Predictions

PROVEAN scores less than -2 are considered deleterious. REVEL scores higher than 0.5 or 0.75 is considered likely pathogenic (higher sensitivity with the former cutoff, higher specificity with the latter cutoff). A PolyPhen-2 score of 0.85 or greater is considered likely pathogenic. PAM scores reflect the chemistry difference between WT and variant amino acid (more negative being greater difference between the two). BLAST-PSSM reflects the evolutionary conservation of residue substitutions, more negative numbers indicate fewer observations of the specific substitution than is expected.

SIFT Sift Score PROVEAN Score Polyphen2 Polyphen2 Score eaRate blastPssm pamScore REVEL
NA NA NA NA NA NA NA NA 0.91

F355Y has 73 neighbors within 15 ångströms that have been found in individuals.

A residue within a folded protein on average has nearest neighbors that fall roughly into two shells: a "nearest" neighbor around 5-6 angstroms and a second shell around 11 angstroms.

ResidueNumber Distance(Å) Variants
261 12.1
262 12.3
263 12.5 V263I
264 10.5
265 7
266 9.3
267 8.8
268 4.5
269 5.8
270 9.1 Q270K
271 8
272 5.2
273 7.9
274 8.1
275 8.5
276 6.8 L276Q
277 10.1
278 12.6
325 13.5
343 13.6
346 14.4 E346K
347 10.4
348 11.2
349 13.5 D349N
351 11.4 G351S G351V
352 11.7
353 7.4 T353I
354 4.7
356 6.6 D356N
357 7.9
358 8.9
359 9.2
360 8.7
361 4.6
362 9.7
363 9.1
364 6.4
365 7.9
366 12.6
367 10.5 R367C R367H
368 10.2
369 14.1 M369K
372 14.9
374 13.6
376 13.8 R376H
377 8.7
378 13.1
379 14.9
380 11
381 9
382 13
384 11.9
385 12 A385T
386 13.7 G386E G386R G386R
389 11.4
392 9.3
393 10.6
395 14.2
396 11.7
397 14.7 I397V
900 14.3
904 13.6
1545 13.6
1546 12.3
1547 14.5
1548 12.3 E1548K G1548K
1549 11.5
1550 11
1551 14.7 D1551N
1620 14.4 T1620K T1620M
1623 13.5 R1623L R1623Q
1624 14.7 V1624I
1627 14.6