S664T Summary

SCN5A S664T was found in 0 papers (see below) with a total of 0 carriers: 0 had BrS1, 0 had LQT3, and 0 had other disease. S664T is not present in gnomAD. S664T has been functionally characterized in 0 papers. Other variants at the same resdue are S664C .S664G .S664I .S664N .S664R .S664R .S664R .S664T . This residue is located in a Non_Hotspot region for BrS1 and in a Non_Hotspot region for Long QT syndrome.

S664T Predictions

PROVEAN scores less than -2 are considered deleterious. REVEL scores higher than 0.5 or 0.75 is considered likely pathogenic (higher sensitivity with the former cutoff, higher specificity with the latter cutoff). A PolyPhen-2 score of 0.85 or greater is considered likely pathogenic. PAM scores reflect the chemistry difference between WT and variant amino acid (more negative being greater difference between the two). BLAST-PSSM reflects the evolutionary conservation of residue substitutions, more negative numbers indicate fewer observations of the specific substitution than is expected.

SIFT Sift Score PROVEAN Score Polyphen2 Polyphen2 Score eaRate blastPssm pamScore REVEL
NA NA NA NA NA NA NA NA 0.743

S664T has 30 neighbors within 15 ångströms that have been found in individuals.

A residue within a folded protein on average has nearest neighbors that fall roughly into two shells: a "nearest" neighbor around 5-6 angstroms and a second shell around 11 angstroms.

ResidueNumber Distance(Å) Variants
649 14.7 C649Y
650 14.2
651 13.7
652 13.2
653 12.6
654 12 E654K
655 11.4 E655K
656 10.7 P656L
657 10.1
658 9.3
659 8.5 R659Q R659W
660 7.6
661 6.6 R661W
662 5.4 A662S
663 3.8
665 3.8 A665S A665T
666 5.4
667 6.6
668 7.6 V668I
669 8.5
670 9.3
671 10.1
672 10.7 A672T
673 11.4
674 12
675 12.6
676 13.2
677 13.7
678 14.2
679 14.7