T353S Summary

SCN5A T353S was found in 0 papers (see below) with a total of 0 carriers: 0 had BrS1, 0 had LQT3, and 0 had other disease. T353S is not present in gnomAD. T353S has been functionally characterized in 0 papers. Other variants at the same resdue are T353A .T353I .T353N .T353P .T353S .T353S . This residue is located in a Hotspot region for BrS1 and in a Non_Hotspot region for Long QT syndrome.

T353S Predictions

PROVEAN scores less than -2 are considered deleterious. REVEL scores higher than 0.5 or 0.75 is considered likely pathogenic (higher sensitivity with the former cutoff, higher specificity with the latter cutoff). A PolyPhen-2 score of 0.85 or greater is considered likely pathogenic. PAM scores reflect the chemistry difference between WT and variant amino acid (more negative being greater difference between the two). BLAST-PSSM reflects the evolutionary conservation of residue substitutions, more negative numbers indicate fewer observations of the specific substitution than is expected.

SIFT Sift Score PROVEAN Score Polyphen2 Polyphen2 Score eaRate blastPssm pamScore REVEL
NA NA NA NA NA NA NA NA 0.937

T353S has 69 neighbors within 15 ångströms that have been found in individuals.

A residue within a folded protein on average has nearest neighbors that fall roughly into two shells: a "nearest" neighbor around 5-6 angstroms and a second shell around 11 angstroms.

ResidueNumber Distance(Å) Variants
265 13.2
268 11.9
269 12.5
271 14.8
272 10.9
273 12.9
274 10.4
275 11.5
276 6.8 L276Q
277 9.2
278 12.8
279 12.6
322 12.9
323 13.1
324 13.3
325 11.1
343 14.3
344 13.3
345 12
346 9.8 E346K
347 5.3
348 5.1
349 6.3 D349N
350 7.8
351 5.4 G351S G351V
352 6.5
354 4.2
355 7.4 F355I
356 9.1 D356N
357 10.7
358 13.5
359 10.9
360 7.5
361 8.8
362 12.5
363 8.4
364 7.1
365 11.4
366 13.4
367 8.7 R367C R367H
368 11.8
372 12.3
373 11.5
374 13.1
375 13.1
376 8.9 R376H
377 7.1
378 13.5
379 12.8
380 8
381 10.1
382 14.1
383 14.1
384 12.6
385 14.6 A385T
392 14.6
393 13.7
899 12.8
900 9.5
901 12.2 E901K
902 14.4
903 11.4
904 7.5
905 13.2
907 11.8
908 13
912 13 Q912R
916 13.9
1550 13.6