T455N Summary

SCN5A T455N was found in 0 papers (see below) with a total of 0 carriers: 0 had BrS1, 0 had LQT3, and 0 had other disease. T455N is not present in gnomAD. T455N has been functionally characterized in 0 papers. Other variants at the same resdue are T455A .T455I .T455N .T455P .T455S .T455S . This residue is located in a Non_Hotspot region for BrS1 and in a Non_Hotspot region for Long QT syndrome.

T455N Predictions

PROVEAN scores less than -2 are considered deleterious. REVEL scores higher than 0.5 or 0.75 is considered likely pathogenic (higher sensitivity with the former cutoff, higher specificity with the latter cutoff). A PolyPhen-2 score of 0.85 or greater is considered likely pathogenic. PAM scores reflect the chemistry difference between WT and variant amino acid (more negative being greater difference between the two). BLAST-PSSM reflects the evolutionary conservation of residue substitutions, more negative numbers indicate fewer observations of the specific substitution than is expected.

SIFT Sift Score PROVEAN Score Polyphen2 Polyphen2 Score eaRate blastPssm pamScore REVEL
NA NA NA NA NA NA NA NA 0.374

T455N has 30 neighbors within 15 ångströms that have been found in individuals.

A residue within a folded protein on average has nearest neighbors that fall roughly into two shells: a "nearest" neighbor around 5-6 angstroms and a second shell around 11 angstroms.

ResidueNumber Distance(Å) Variants
440 14.7
441 14.2
442 13.7
443 13.2
444 12.6
445 12 H445D
446 11.4 E446K
447 10.7 A447G
448 10.1
449 9.3 T449A
450 8.5
451 7.6
452 6.6
453 5.4 V453M
454 3.8
456 3.8 V456M
457 5.4
458 6.6 R458C R458H
459 7.6
460 8.5
461 9.3 L461V
462 10.1 E462K
463 10.7 M463R
464 11.4
465 12
466 12.6 L466F L466F
467 13.2
468 13.7 P468L
469 14.2
470 14.7 N470K N470K